This text offers introductory knowledge of a wide range of clustering and other quantitative techniques used to solve biological problems.

This book focuses on the data mining, systems biology, and bioinformatics computational methods that can be used to summarize biological networks. Specifically, it discusses an array of techniques related to biological network clustering, network summarization, and differential network analysis which enable readers to uncover the functional and topological organization hidden in a large biological network. The authors also examine crucial open research problems in this arena. Academics, researchers, and advanced-level students will find this book to be a comprehensive and exceptional resource for understanding computational techniques and their applications for a summary of biological networks.

Provides an overview of the developments and advances in the field of network clustering and blockmodeling over the last 10 years This book offers an integrated treatment of network clustering and blockmodeling, covering all of the newest approaches and methods that have been developed over the last decade. Presented in a comprehensive manner, it offers the foundations for understanding network structures and processes, and features a wide variety of new techniques addressing issues that occur during the partitioning of networks across multiple disciplines such as community detection, blockmodeling of valued networks, role assignment, and stochastic blockmodeling. Written by a team of international experts in the field, Advances in Network Clustering and Blockmodeling offers a plethora of diverse perspectives covering topics such as: bibliometric analyses of the network clustering literature; clustering approaches to networks; label propagation for clustering; and treating missing network data before partitioning. It also examines the partitioning of signed networks, multimode networks, and linked networks. A chapter on structured networks and coarsegrained descriptions is presented, along with another on scientific coauthorship networks. The book finishes with a section covering conclusions and directions for future work. In addition, the editors provide numerous tables, figures, case studies, examples, datasets, and more. Offers a clear and insightful look at the state of the art in network clustering and blockmodeling Provides an excellent mix of mathematical rigor and practical application in a comprehensive manner Presents a suite of new methods, procedures, algorithms for partitioning networks, as well as new techniques for visualizing matrix arrays Features numerous examples throughout, enabling readers to gain a better understanding of research methods and to conduct their own research effectively Written by leading contributors in the field of spatial networks analysis Advances in Network Clustering and Blockmodeling is an ideal book for graduate and undergraduate students taking courses on network analysis or working with networks using real data. It will also benefit researchers and practitioners interested in network analysis.

This proceedings volume examines all major areas in computer science, mathematics (especially logic) and the physical sciences, especially computation, algorithms, complexity and computability theory.

The 4th Annual International Conference on Combinatorial Optimization and Applications (COCOA 2010) took place in Big Island, Hawaii, USA, December 18–20, 2010. Past COCOA conferences were held in Xi’an, China (2007), Newfoundland, Canada (2008)and Huangshan, China (2009). COCOA2010providedaforumforresearchersworkingintheareasofcom- natorial optimization and its applications. In addition to theoretical results, the conference also included recent works on experimental and applied research of general algorithmic interest. The Program Committee received 108 submissions from more than 23 countries and regions, including Australia, Austria, Canada, China, Denmark, France, Germany, Hong Kong, India, Italy, Japan, Korea, Mexico, New Zealand, Poland, Slovak Republic, Spain, Sweden, Switzerland, Taiwan, UK, USA, Vietnam, etc. Among the 108 submissions, 49 regular papers were selected for presentation at the conference and are included in this volume. Some of these papers will be selected for publication in a special issue of the Journal of Combinatorial Optimization, a special issue of Theoretical Computer Science, a special issue of Optimization Letters, and a special issue of Discrete Mathematics, Algorithms and Applications under the standard refereeing procedure.

Research on the problem of clustering tends to be fragmented across the pattern recognition, database, data mining, and machine learning communities. Addressing this problem in a unified way, Data Clustering: Algorithms and Applications provides complete coverage of the entire area of clustering, from basic methods to more refined and complex data clustering approaches. It pays special attention to recent issues in graphs, social networks, and other domains. The book focuses on three primary aspects of data clustering: Methods, describing key techniques commonly used for clustering, such as feature selection, agglomerative clustering, partitional clustering, density-based clustering, probabilistic clustering, grid-based clustering, spectral clustering, and nonnegative matrix factorization Domains, covering methods used for different domains of data, such as categorical data, text data, multimedia data, graph data, biological data, stream data, uncertain data, time series clustering, high-dimensional clustering, and big data Variations and Insights, discussing important variations of the clustering process, such as semisupervised clustering, interactive clustering, multiview clustering, cluster ensembles, and cluster validation In this book, top researchers from around the world explore the characteristics of clustering problems in a variety of application areas. They also explain how to glean detailed insight from the clustering process—including how to verify the quality of the underlying clusters—through supervision, human intervention, or the automated generation of alternative clusters.

Optimization in Science and Engineering is dedicated in honor of the 60th birthday of Distinguished Professor Panos M. Pardalos. Pardalos’s past and ongoing work has made a significant impact on several theoretical and applied areas in modern optimization. As tribute to the diversity of Dr. Pardalos’s work in Optimization, this book comprises a collection of contributions from experts in various fields of this rich and diverse area of science. Topics highlight recent developments and include: Deterministic global optimization Variational inequalities and equilibrium problems Approximation and complexity in numerical optimization Non-smooth optimization Statistical models and data mining Applications of optimization in medicine, energy systems, and complex network analysis This volume will be of great interest to graduate students, researchers, and practitioners, in the fields of optimization and engineering.

An introduction to biological networks and methods for their analysis Analysis of Biological Networks is the first book of its kind to provide readers with a comprehensive introduction to the structural analysis of biological networks at the interface of biology and computer science. The book begins with a brief overview of biological networks and graph theory/graph algorithms and goes on to explore: global network properties, network centralities, network motifs, network clustering, Petri nets, signal transduction and gene regulation networks, protein interaction networks, metabolic networks, phylogenetic networks, ecological networks, and correlation networks. Analysis of Biological Networks is a self-contained introduction to this important research topic, assumes no expert knowledge in computer science or biology, and is accessible to professionals and students alike. Each chapter concludes with a summary of main points and with exercises for readers to test their understanding of the material presented. Additionally, an FTP site with links to author-provided data for the book is available for deeper study. This book is suitable as a resource for researchers in computer science, biology, bioinformatics, advanced biochemistry, and the life sciences, and also serves as an ideal reference text for graduate-level courses in bioinformatics and biological research.

This volume includes contributions from diverse disciplines including electrical engineering, biomedical engineering, industrial engineering, and medicine, bridging a vital gap between the mathematical sciences and neuroscience research. Covering a wide range of research topics, this volume demonstrates how various methods from data mining, signal processing, optimization and cutting-edge medical techniques can be used to tackle the most challenging problems in modern neuroscience.

As the age of Big Data emerges, it becomes necessary to take the five dimensions of Big Data- volume, variety, velocity, volatility, and veracity- and focus these dimensions towards one critical emphasis - value. The Encyclopedia of Business Analytics and Optimization confronts the challenges of information retrieval in the age of Big Data by exploring recent advances in the areas of knowledge management, data visualization, interdisciplinary communication, and others. Through its critical approach and practical application, this book will be a must-have reference for any professional, leader, analyst, or manager interested in making the most of the knowledge resources at their disposal.