Topics include: Cocaine intoxication, Carbon monoxide poisoning, Update on miscellaneous drug overdoses, T oxidromes, Cardiac glycoside toxicity, Acetaminophen overdose, Envenomations, Methanol and ethylene glycol ingestion, and Toxicologic causes of ketoacidosis.

This issue of Critical Care Clinics, guest edited by Dr. Janice L. Zimmerman, focuses on Toxicology. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: Pharmacokinetic and pharmacodynamic principles for toxicology, Use of extracorporeal techniques in poisonings, Drugs of Abuse, Cardiovascular Drug Toxicity, Anticoagulant and Anti-platelet Drug Toxicity and Psychotropic Agents.

This issue of Critical Care Clinics focuses on Psychiatric Aspects of Critical Care Medicine. Editor Jose Maldonado has assembled an expert team of authors on topics such as: Psychiatric Aspects of Organ Transplantation in Critical Care; Medical Complications of Psychiatric Treatment; Psychiatric and Palliative Care in the ICU; Psychiatric Aspects of Heart and Lung Disease in Critical Care; Alcohol Withdrawal Syndromes: Assessment and Management; Substance Abuse and Withdrawal in the Critical Care Setting; Mood Disorders and The Outcome of Suicidal Thoughts and Attempts; Anxiety Disorders and the Outcomes of Trauma; Assessment and Management of Toxidromes in the Critical Care Unit; Neuropsychiatric Consequences of Trauma and Head Injury; Detection and Management of Pre-Existing Cognitive Impairment in the Critical Care Unit; Delirium: Pathophysiology, Diagnosis and Treatment; Neuropsychiatric Aspects of Infectious Processes.

This issue of Critical Care Clinics, guest edited by Drs. Marie Baldisseri, Mary Reed, and Randy Wax, in collaboration with Consulting Editor John Kellum, is devoted to Intensive Care Unit in Disaster. Topics in this issue include: Intensive care role in disaster management; Preparing the ICU for disaster; Augmenting capacity; Triage; Natural disasters; Biological/pandemic disasters; Chemical disasters; Radiation; Anthropogenic (terrorist/criminal act) disasters; Special populations (i.e., chronically ill, morbidly obese, pregnant); Pediatrics; Austere environments; Hospital as disaster Ground Zero; and Special considerations (i.e., mental health, ethics, public relations).

Topics include: Why Economics Matters to Critical Care Clinicians, Overview of Health Economics: Basics Concept for Clinicians;Health Economic Methods; Costs of Critical Care Medicine; Economic Aspects of Sepsis and Severe Infections; Economic Aspects of Renal Failure and Acute Kidney Injury; Economic Aspects of Cardiovascular Disease; Economics of Mechanical Ventilation and Respiratory Failure and Comparative Effective Research and Health Care Reform.

This issue of Critical Care Clinics, guest edited by Drs. John Kellum and Dana Fuhrman, focuses on Acute Kidney Injury. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: Acute Kidney Injury and Disease, AKI in Cardiac Surgery, AKI in Sepsis, Hepatorenal Disease, Cardiorenal Syndrome, Onconephrology, Renal Functional Reserve and more.

Topics include: A Critical re-appraisal of Factor VIIa; Thrombocytopenia: Hit vs non-HIT causes; Transfusion Reactions: Newer concepts on the pathophysiology, incidence, treatment and prevention of TRALI; The utility of diagnostic scoring systems for DIC; Newer anticoagulants; Anemia in the ICU; The role of plasmapheresis in critical illness; The use of erythropoiesis stimulating agents in the ICU; and Coagulopathy in the ICU: DIC vs Liver disease. Is this distinction important?

Topics include: Automated external defibrillation, Airway management during CPR, Could we remove ventilation from ABC's of CPR?, Advances in mechanical interventions during CPR, The role of vasopressor agents during CPR, Optimizing the timing of defibrillation: the role of VF waveform analysis during CPR, Therapeutic hypothermia during and after CPR, and Advances in brain resuscitation: beyond hypothermia.

This issue of Critical Care Clinics, Guest Edited by Dr. Stephen M. Pastores and Dr. Wendy R. Greene, focuses on Critical Care of the Cancer Patient (Pastores) and Geriatric Critical Care (Greene). Dr. Pastores' section of the issue is devoted to Critical Care of the Cancer Patient and includes the following topics: Triage and Prognostication of Cancer Patients Admitted to the ICU; ICU Organization and Interdisciplinary Care for Critically Ill Patients with Cancer; Critical Care of the Hematopoietic Stem Cell Transplant Recipient; Management of Drug Toxicities; Acute Kidney Injury in the Critically Ill Patient with Cancer; Infectious Disease Complications in Cancer Patients; and Palliative, Ethics, and End-of-Life Care Issues in the Cancer Patient. Dr. Green's section of the issue, devoted to Geriatric Critical Care, includes the following topics: The effect of aging physiology on critical care; The frailty syndrome: a critical issue in geriatric oncology; Detection of delirium in the intensive care unit: comparison of confusion assessment method for the intensive care unit with confusion assessment method ratings; Evidence-based geriatric nursing protocols for best practice; The effect of dementia in the critically ill geriatric patient; Nutritional assessment: a primary component of multidimensional geriatric assessment in the ICU; Rehabilitation concerns in the geriatric critically ill and injured; and Geriatric palliative care.

This issue of Critical Care Clinics focuses on two crucial topics: Enhanced Recovery in the ICU After Cardiac Surgery (guest edited by Dr. Daniel Engelman) and New Developments in Cardiopulmonary Resuscitation (guest edited by Dr. Clifton Callaway).