Therapeutic Proteins And Peptides
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Author |
: |
Publisher |
: Academic Press |
Total Pages |
: 410 |
Release |
: 2018-04-18 |
ISBN-10 |
: 9780128143414 |
ISBN-13 |
: 012814341X |
Rating |
: 4/5 (14 Downloads) |
Synopsis Therapeutic Proteins and Peptides by :
Therapeutic Proteins and Peptides, Volume 112 in an ongoing series promotes further research in the discovery of new therapeutic targets that can be affected by therapeutic proteins and peptides to cure or manage symptoms of human diseases, with this release focusing on the Rational Design of Stable Liquid Formulations of Biopharmaceuticals, Formulation strategies for peptides, proteins and antibodies using nanotechnology, the Solution structural dynamics of therapeutic peptides and their adsorption on plasmonic nanoparticles, Enzymatic approaches of protein-polymer conjugation, Chimeric small antibody fragments as a strategy to deliver therapeutic payloads, Smart cell-penetrating peptide-based techniques for cytoplasmic delivery of therapeutic macromolecules, and more. - Describes advances in the discovery and application of therapeutic proteins/peptides which allow better targeting to the site of treatment and cause fewer adverse effects when compared to chemical compounds used for disease treatment - Targeted to a very wide audience of specialists, researchers and students - Written by well-renown authorities in their field - Includes a number of high quality illustrations, figures and tables
Author |
: Ajay K. Banga |
Publisher |
: CRC Press |
Total Pages |
: 396 |
Release |
: 2015-04-23 |
ISBN-10 |
: 9781466566071 |
ISBN-13 |
: 1466566078 |
Rating |
: 4/5 (71 Downloads) |
Synopsis Therapeutic Peptides and Proteins by : Ajay K. Banga
There are more than 500 biopharmaceuticals on the market, including more than 200 therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. These products include more than 40 monoclonal antibodies, for indications ranging from treatment or mitigation of various types of cancer to rheumatoid arthritis. The c
Author |
: Ajay K. Banga |
Publisher |
: CRC Press |
Total Pages |
: 375 |
Release |
: 2005-09-14 |
ISBN-10 |
: 9781420039832 |
ISBN-13 |
: 1420039830 |
Rating |
: 4/5 (32 Downloads) |
Synopsis Therapeutic Peptides and Proteins by : Ajay K. Banga
Upon publication of the first edition of Therapeutic Peptides and Proteins ten years ago there were only 19 biotechology medicines on the market. Currently there are more than 100, with at least 400 more in various stages of development. That alone would be grounds for a new edition. Add to that the fact that it is still difficult to find up
Author |
: C. Mark Smales |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 481 |
Release |
: 2008-02-04 |
ISBN-10 |
: 9781592599226 |
ISBN-13 |
: 1592599222 |
Rating |
: 4/5 (26 Downloads) |
Synopsis Therapeutic Proteins by : C. Mark Smales
With the recent completion of the sequencing of the human genome, it is widely anticipated that the number of potential new protein drugs and targets will escalate at an even greater rate than that observed in recent years. However, identification of a potential target is only part of the process in developing these new next generation protein-based “drugs” that are increasingly being used to treat human disease. Once a potential protein drug has been identified, the next rate-limiting step on the road to development is the production of sufficient authentic material for testing, charact- ization, clinical trials, and so on. If a protein drug does actually make it through this lengthy and costly process, methodology that allows the production of the protein on a scale large enough to meet demand must be implemented. Furthermore, large-scale production must not compromise the authenticity of the final product. It is also nec- sary to have robust methods for the purification, characterization, viral inactivation and continued testing of the authenticity of the final protein product and to be able to formulate it in a manner that retains both its biological activity and lends itself to easy administration. Therapeutic Proteins: Methods and Protocols covers all aspects of protein drug production downstream of the discovery stage. This volume contains contributions from leaders in the field of therapeutic protein expression, purification, characterization, f- mulation, and viral inactivation.
Author |
: Randall J. Mrsny |
Publisher |
: CRC Press |
Total Pages |
: 266 |
Release |
: 2009-10-19 |
ISBN-10 |
: 9781420078077 |
ISBN-13 |
: 1420078070 |
Rating |
: 4/5 (77 Downloads) |
Synopsis Proteins and Peptides by : Randall J. Mrsny
Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is
Author |
: Zahra Shahrokh |
Publisher |
: |
Total Pages |
: 248 |
Release |
: 1997 |
ISBN-10 |
: UOM:39015041771521 |
ISBN-13 |
: |
Rating |
: 4/5 (21 Downloads) |
Synopsis Therapeutic Protein and Peptide Formulation and Delivery by : Zahra Shahrokh
This volume reviews protein stability and the analytical and biophysical characterization of proteins. It emphasizes drug delivery approaches, especially local delivery through the skin. Including both academic and industrial perspectives from such companies as Genentech, Amgen, and Merck, the book also discusses novel drug delivery polymers and the development of pharmaceutical protein formulations.
Author |
: Chris Van Der Walle |
Publisher |
: Academic Press |
Total Pages |
: 381 |
Release |
: 2011-05-12 |
ISBN-10 |
: 9780123849366 |
ISBN-13 |
: 0123849365 |
Rating |
: 4/5 (66 Downloads) |
Synopsis Peptide and Protein Delivery by : Chris Van Der Walle
The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. - Discusses the most recent data, ideas and concepts - Presents case studies and an industrial perspective - Details information from the molecular level to bioprocessing - Thought provoking, for the novice to the specialist - Timely, for today's biopharmaceuticals market
Author |
: Puneet Tyagi |
Publisher |
: Academic Press |
Total Pages |
: 318 |
Release |
: 2022-08-18 |
ISBN-10 |
: 9780128210604 |
ISBN-13 |
: 0128210605 |
Rating |
: 4/5 (04 Downloads) |
Synopsis Oral Delivery of Therapeutic Peptides and Proteins by : Puneet Tyagi
Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport. Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource. Demonstrates how proteins and peptides transport throughout the gastrointestinal tract and how to evaluate their biological fate when encapsulated into certain delivery systems Examines developing technologies to improve future oral bioavailability Includes the in vitro and preclinical techniques needed for development
Author |
: Fahmida Khatoon Zahid Balouch |
Publisher |
: Springer Nature |
Total Pages |
: 178 |
Release |
: 2022-09-28 |
ISBN-10 |
: 9789811678974 |
ISBN-13 |
: 9811678979 |
Rating |
: 4/5 (74 Downloads) |
Synopsis Therapeutic Proteins Against Human Diseases by : Fahmida Khatoon Zahid Balouch
This book compiles updated research about the implications of therapeutic proteins in various human diseases. The initial chapters of the book provide basic information on the therapeutic proteins and discuss techniques for their formulation, production, and analytic approaches for their characterization. The subsequent chapters shed light on therapies based on therapeutic proteins against metabolic disorders, neurological disorders, cancer, autoimmune disorders, and infectious diseases. Importantly, it presents the factors influencing the immunogenicity of therapeutic proteins, including, genetic factors, disease type, and origin of therapeutic protein, dose frequency, administration route, and treatment duration. The book also reviews the strategies for reducing immunogenicity associated with therapeutic proteins, including PEGylation, site specific mutagenesis, exon shuffling, and humanizing of monoclonal antibodies. Further, it presents strategies for improving the typical drawback associated with protein therapeutics including instability and limited penetration through biological barriers. This book covers various computational methods that are commonly used for designing therapeutic proteins and in silico method for predicting and improving in vivo efficacy of the therapeutic molecules. Lastly, the book highlights the recent advances in developing nanosized delivery systems to improve safety and efficacy of protein therapeutics. This book caters to students and researchers of medicinal chemistry, pharmaceutical sciences and therapeutics. It is also useful to clinicians working with therapeutic proteins.
Author |
: Rodney Pearlman |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 371 |
Release |
: 2013-06-29 |
ISBN-10 |
: 9781489912367 |
ISBN-13 |
: 1489912363 |
Rating |
: 4/5 (67 Downloads) |
Synopsis Stability and Characterization of Protein and Peptide Drugs by : Rodney Pearlman
This is the first volume to make available specific case histories of therapeutic proteins and peptides that have been marketed or are currently under clinical testing. The editors have selected a wide range of molecules derived from monoclonal antibodies, recombinant DNA, and natural and chemical sources to provide formulation scientists with practical examples of the development of pharmaceutical products.