Oral Delivery Of Therapeutic Peptides And Proteins
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Author |
: Puneet Tyagi |
Publisher |
: Academic Press |
Total Pages |
: 318 |
Release |
: 2022-08-18 |
ISBN-10 |
: 9780128210604 |
ISBN-13 |
: 0128210605 |
Rating |
: 4/5 (04 Downloads) |
Synopsis Oral Delivery of Therapeutic Peptides and Proteins by : Puneet Tyagi
Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport. Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource. Demonstrates how proteins and peptides transport throughout the gastrointestinal tract and how to evaluate their biological fate when encapsulated into certain delivery systems Examines developing technologies to improve future oral bioavailability Includes the in vitro and preclinical techniques needed for development
Author |
: Chris Van Der Walle |
Publisher |
: Academic Press |
Total Pages |
: 381 |
Release |
: 2011-05-12 |
ISBN-10 |
: 9780123849366 |
ISBN-13 |
: 0123849365 |
Rating |
: 4/5 (66 Downloads) |
Synopsis Peptide and Protein Delivery by : Chris Van Der Walle
The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. - Discusses the most recent data, ideas and concepts - Presents case studies and an industrial perspective - Details information from the molecular level to bioprocessing - Thought provoking, for the novice to the specialist - Timely, for today's biopharmaceuticals market
Author |
: Ajay K. Banga |
Publisher |
: CRC Press |
Total Pages |
: 375 |
Release |
: 2005-09-14 |
ISBN-10 |
: 9781420039832 |
ISBN-13 |
: 1420039830 |
Rating |
: 4/5 (32 Downloads) |
Synopsis Therapeutic Peptides and Proteins by : Ajay K. Banga
Upon publication of the first edition of Therapeutic Peptides and Proteins ten years ago there were only 19 biotechology medicines on the market. Currently there are more than 100, with at least 400 more in various stages of development. That alone would be grounds for a new edition. Add to that the fact that it is still difficult to find up
Author |
: Ajay K. Banga |
Publisher |
: CRC Press |
Total Pages |
: 396 |
Release |
: 2015-04-23 |
ISBN-10 |
: 9781466566071 |
ISBN-13 |
: 1466566078 |
Rating |
: 4/5 (71 Downloads) |
Synopsis Therapeutic Peptides and Proteins by : Ajay K. Banga
There are more than 500 biopharmaceuticals on the market, including more than 200 therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. These products include more than 40 monoclonal antibodies, for indications ranging from treatment or mitigation of various types of cancer to rheumatoid arthritis. The c
Author |
: Yogeshwar Bachhav |
Publisher |
: John Wiley & Sons |
Total Pages |
: 470 |
Release |
: 2019-12-04 |
ISBN-10 |
: 9783527343966 |
ISBN-13 |
: 3527343962 |
Rating |
: 4/5 (66 Downloads) |
Synopsis Innovative Dosage Forms by : Yogeshwar Bachhav
Teaches future and current drug developers the latest innovations in drug formulation design and optimization This highly accessible, practice-oriented book examines current approaches in the development of drug formulations for preclinical and clinical studies, including the use of functional excipients to enhance solubility and stability. It covers oral, intravenous, topical, and parenteral administration routes. The book also discusses safety aspects of drugs and excipients, as well as regulatory issues relevant to formulation. Innovative Dosage Forms: Design and Development at Early Stage starts with a look at the impact of the polymorphic form of drugs on the preformulation and formulation development. It then offers readers reliable strategies for the formulation development of poorly soluble drugs. The book also studies the role of reactive impurities from the excipients on the formulation shelf life; preclinical formulation assessment of new chemical entities; and regulatory aspects for formulation design. Other chapters cover innovative formulations for special indications, including oncology injectables, delayed release and depot formulations; accessing pharmacokinetics of various dosage forms; physical characterization techniques to assess amorphous nature; novel formulations for protein oral dosage; and more. -Provides information that is essential for the drug development effort -Presents the latest advances in the field and describes in detail innovative formulations, such as nanosuspensions, micelles, and cocrystals -Describes current approaches in early pre-formulation to achieve the best in vivo results -Addresses regulatory and safety aspects, which are key considerations for pharmaceutical companies -Includes case studies from recent drug development programs to illustrate the practical challenges of preformulation design Innovative Dosage Forms: Design and Development at Early Stage provides valuable benefits to interdisciplinary drug discovery teams working in industry and academia and will appeal to medicinal chemists, pharmaceutical chemists, and pharmacologists.
Author |
: Akwete Adjei |
Publisher |
: CRC Press |
Total Pages |
: 952 |
Release |
: 1997-07-08 |
ISBN-10 |
: 0824797809 |
ISBN-13 |
: 9780824797805 |
Rating |
: 4/5 (09 Downloads) |
Synopsis Inhalation Delivery of Therapeutic Peptides and Proteins by : Akwete Adjei
This exhaustive reference-the first book of its kind to describe in detail the functionality of the human respiratory tract and its impact on both local and systemic delivery of biotherapeutic and macromolecular drug systems-offers comprehensive analyses of peptide and protein drug delivery through the lung. Summarizes over 130 patents granted worldwide on alternative systems for pulmonary delivery of therapeutic drugs-especially peptides and proteins! Examining macromolecular drug delivery as an efficient, patient-friendly, and cost-effective method of treatment, Inhalation Delivery of Therapeutic Peptides and Proteins discusses airway physiology and biomechanics the pharmaceutical concerns associated with the respiratory tract as a viable port of drug entry to the body key peptide drugs under development and in use to treat local lung disease, including cyclosporines, interferons, antitrypsins, protease inhibitors, and deoxyribonucleases the systemic delivery of peptide and protein drugs using fine-particle technology gene therapy employing gene delivery through the airways new developments in pulmonary delivery technologies emphasizing inhaled peptide and protein drugs guidelines for the successful introduction of peptide inhalation aerosol products into the marketplace and much more!
Author |
: Miguel Castanho |
Publisher |
: John Wiley & Sons |
Total Pages |
: 547 |
Release |
: 2011-10-24 |
ISBN-10 |
: 9783527636747 |
ISBN-13 |
: 3527636749 |
Rating |
: 4/5 (47 Downloads) |
Synopsis Peptide Drug Discovery and Development by : Miguel Castanho
Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.
Author |
: Binghe Wang |
Publisher |
: John Wiley & Sons |
Total Pages |
: 740 |
Release |
: 2016-04-18 |
ISBN-10 |
: 9781118833360 |
ISBN-13 |
: 1118833368 |
Rating |
: 4/5 (60 Downloads) |
Synopsis Drug Delivery by : Binghe Wang
Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery
Author |
: Ved Srivastava |
Publisher |
: Royal Society of Chemistry |
Total Pages |
: 572 |
Release |
: 2019-08-28 |
ISBN-10 |
: 9781788014335 |
ISBN-13 |
: 1788014332 |
Rating |
: 4/5 (35 Downloads) |
Synopsis Peptide Therapeutics by : Ved Srivastava
Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal policy or guidelines on CMC for peptide-based drugs. Regulators use a risk-based approach, reviewing applications on a case-by-case basis. Peptide Therapeutics: Strategy and Tactics for Chemistry, Manufacturing, and Controls covers efficient manufacturing of peptide drug substances, a review of the process for submitting applications to the regulatory authority for drug approval, a holistic approach for quality attributes and quality control from a regulatory perspective, emerging analytical tools for the characterisation of impurities, and the assessment of stability. This book is an essential reference work for students and researchers, in both academia and industry, with an interest in learning about CMC, and facilitating development and manufacture of peptide-based drugs.
Author |
: Randall J. Mrsny |
Publisher |
: CRC Press |
Total Pages |
: 266 |
Release |
: 2009-10-19 |
ISBN-10 |
: 9781420078077 |
ISBN-13 |
: 1420078070 |
Rating |
: 4/5 (77 Downloads) |
Synopsis Proteins and Peptides by : Randall J. Mrsny
Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is