This book discusses the role of the microbiome in rheumatic diseases and details its implications for patient treatment. Recently, with technological advances, there has been significant research into the microbiome. This has enabled us to more profoundly understand its role in our immune system maturation as well as the role played by microorganisms in autoimmunity and the deeply related rheumatic diseases. This book comprehensively explains the emerging microbiome research through the interrelationships of biomedical sciences, including: immunology, microbiology, bioinformatics, and, with special emphasis, the clinical aspect of rheumatology. It examines the interplay between infectious organisms and major autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis, juvenile arthritis, systemic lupus erythematosus, and vasculitis, and explains how to apply that knowledge to diagnostic techniques and treatment decisions. The international team of expert authors provides insight into current therapies and future interventions specifically targeting the microbiota and explores the impact of our deeper understanding on enhancing personalized medicine. The Microbiome in Rheumatic Diseases and Infection is an essential resource for rheumatologists, pediatricians, internists, microbiologists, and critical care providers caring for children and adults with rheumatic diseases.

This book provides a comprehensive and up-to-date review of the basic and clinical aspects of infections and infectious processes that trigger or aggravate a variety of autoimmune and inflammatory musculoskeletal disorders. It delivers a timely update on the interactions between infection and rheumatic diseases in order to provide clinicians with the tools they need for proper diagnosis and treatment. The book is divided into five main sections. The first examines the basic aspects of bacterial infections with a discussion of molecular biology, the microbiome, various types of bacteria that cause infection, and recent advances in biologic therapy. The next section focuses on different forms of viral arthritis including hepatitis arthritis, arthritis associated with alpha viruses, and parvovirus-related arthritis. Subsequent chapters then discuss arthritis caused by mycobacteria, fungi, spirochete, and other miscellaneous arthritides. Following this are various analyzations on reactive arthritis and infection-related rheumatic diseases such as Whipple’s Disease, SAPHO Syndrome, rheumatic fever, and HIV-associated rheumatic manifestations. Finally, the book closes with three chapters on external impacts on infectious diseases such as climate change, vaccinations and systemic lupus erythematosus. Infections and the Rheumatic Diseases is an essential resource for physicians and related professionals, residents, fellows, graduate students, and nurses in rheumatology, clinical immunology, and internal medicine.

Microbiome and Rheumatic Diseases, An Issue of Rheumatic Disease Clinics of North America

Autoimmune and rheumatic diseases are two close allies. Differential diagnosis of both disease groups can be cumbersome since the clinical signs of rheumatic and infectious disorders are very similar. This book addresses the fact that infectious disease can either mimic or complicate rheumatic diseases. In the first part, cases of with standard rheumatic symptoms patients triggered by infections and differential diagnosis are presented. The second part is dedicated to the complications of rheumatic disease infections. Standard patient cases are presented as well as risk factors, clinical features and microbial spectra. Further chapters inform about the impact of anti-rheumatic and immunomodulatory drug therapies (incl. biological agents) on infectious risk, the specific aspects of vaccination during immunosuppressive therapy and issues about the infectious risk and chemoprophylaxis during orthopedic surgery. This book provides clinicians a detailed insight between rheumatic and infectious disease.

In this first-of-its-kind issue of Rheumatic Disease Clinics, guest editor Dr. Bryant R. England brings his considerable expertise to the topic of Environmental Triggers for Rheumatic Diseases. In practical, state-of-the-art articles, top experts examine the connection between some of the most commonly seen rheumatic disease and environmental triggers for the disease. Contains 13 practice-oriented topics including inhalant and mucosal-related environmental risks for rheumatoid arthritis; lifestyle, hormonal, and microbial-related environmental risks for rheumatoid arthritis; environmental risks for systemic lupus erythematosus; environmental risks for osteoarthritis; targeting environmental risks to prevent rheumatic diseases; and more. Provides in-depth clinical reviews on environmental triggers for rheumatic diseases, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Rheumatism: From the Advent of Experimental Science to the Impact of Bacteriology follows Rheumatism: Its History from Paleo-pathology to the Advent of Experimental Science, which was published in 2015. The concept of the present book is that, as bacteriology developed as a scientific discipline, it gradually replaced the vague patho-physiologic concepts that explained "rheumatism." Galen in about 200 CE displayed certainty about the basis of disease causation that remained satisfactory for 1700 years. The chronology wherein the existence of bacteria became recognized and eventually, over learned opposition became pathogens, is told in the introduction in excerpts from the writings of important participants. The main chapters of this book portray the historical development of the understanding of five rheumatic diseases. The first is gonorrheal rheumatism, which became gonococcal arthritis. It posed the question how, even if scientists acknowledge that a specific bacterial species is the cause of local symptoms, can this unpredictably cause symptoms at different locations. A chapter on reactive arthritis describes a disease that closely mimics gonorrheal rheumatism, and is shown to be caused by several different microbes, none of which are related to the bacterium that causes gonorrheal rheumatism. Chapter Four is a scientific biography of a German surgeon that exemplifies the consequences of becoming wedded to an erroneous discovery, and the protracted influence this may have on an entire area of research. His discovery was the bacterial cause of rheumatoid arthritis. This is followed in Chapter Five by the development of understanding the cause of rheumatic fever, and how this helped to differentiate this disease from rheumatoid arthritis. Chapter Six focuses on polymyositis and dermatomyositis, related diseases that bear some resemblance to trichinosis, a parasitic infection, as well as sometimes overlapping symptomatically with the last disease to be portrayed, scleroderma or systemic sclerosis. Thus, rheumatic syndromes have become recognized both as disease entities and increasingly subdivided by immunologic distinctions, the successor to bacteriologic distinctions. To facilitate access to the historically important references of contributors/investigators, biographical articles are inserted wherever possible. An index of these articles from both books is provided, as well as a glossary of terms with which some readers may be unfamiliar. Finally there is a bibliography of the author's publications that pertain to the history of rheumatology and historical aspects of so-called rheumatic diseases.

With its comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, Firestein & Kelley's Textbook of Rheumatology remains your reference of choice in this evolving field. The fully revised 12th Edition retains the user-friendly, full color format, providing in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. New editors, new chapters, and new illustrations keep you fully up to date on recent advances in genetics and the microbiome, current therapies, and other rapid changes in the field. - Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, physical examination, and disease pathogenesis, manifestations and treatment?including key data on outcomes to better inform clinical decision making. - Includes new or significantly revised chapters on Pre-Clinical Autoimmunity; The Microbiome in Health and Disease; Physical Therapy and Rehabilitation; Nutrition and Rheumatic Disease; Classification and Epidemiology of Spondyloarthritis; Etiology and Pathogenesis of Osteoarthritis; COVID and Rheumatic Disease; Vaccination in Rheumatic Disease; Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer; and many more. - Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs; many new illustrations highlight diseases among racially diverse patients. - Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editors Drs. Ted Mikuls and Tuhina Neogi. - Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints.

This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.