The new edition of this atlas integrates all significant advances made in the past 15 years in molecular pathology, tumor virology, and genetics of cervical cancer. It emphasizes the importance of these advances in facilitating its pathological diagnosis and in op- mizing clinical management and prognosis. A new chapter on immunohistochemistry has been added, which includes refined detection methods, e. g., the overexpression of INK4a p16 as a molecular marker in the early differential diagnosis of premalignant - sions. The section on etiology and pathogenesis in human papillomavirus-induced neoplasia has been incorporated to represent new insights into the sequences of cel- lar and nuclear deregulation at the molecular level. All chapters have been revised to - clude the newest advances and relevant experiences in how to interpret and manage cervical disease; they are supported by the addition of 35 new microphotographic ill- trations. The tumor nomenclature is adapted to the latest edition of the WHO classi- cation; the morphology code of the international classification of diseases for oncology (ICD-O) has been added. We have also updated the list of references by adding recent relevant publications. Again, the staff of Springer-Verlag deserve our thanks for their patience and skill in preparing the manuscript and in reproducing the microphotographs. Heidelberg, February 2005 Gisela Dallenbach-Hellweg, Magnus von Knebel Doeberitz, and Marcus J. Trunk Heading2 Preface to the First Edition During the past decade our understanding of the histopathology of the cervix uteri has changed greatly.

An atlas covering the normal and pathologic histology of the uterine cervix. Differential diagnosis is given in detail yet related to clinical aspects, so that a functional de- scription of benefit in daily practice is achieved.

Functional description of the entire aspect of the morphologic changes in the uterine cervix taking into consideration cytologic, histpathologic, immunohistochemical and virological findings. There will be specific therapeutic proposals based on an accurate diagnosis. Utilization of other related scientific disciplines such as electron microscopy, endocrinology, biochemistry, cytogenetics will be emphasized. The purpose is a close interdisciplinary cooperation between gynecologists and pathologists.

1. Introduction -- 2. Phenotyping -- 3. Necropsy and histology -- 4. Mammary Gland -- 5. Skeletal System -- 6. Nose, sinus, pharynx and larynx -- 7. Oral cavity and teeth -- 8. Salivary glands -- 9. Respiratory -- 10. Cardiovascular -- 11. Upper GI -- 12. Lower GI -- 13. Liver and gallbladder -- 14. Pancreas -- 15. Endocrine System -- 16. Urinary System -- 17. Female Reproductive System -- 18. Male Reproductive System -- 19. Hematopoietic and Lymphoid Tissues -- 20. Nervous System -- 21. Special senses, eye -- 22. Special senses, ear -- 23. Skin and adnexa -- Index.

This colposcopy manual was developed in the context of the cervical cancer screening research studies of the International Agency for Research on Cancer (IARC) and the related technical support provided to national programs. It is thus a highly comprehensive manual, both for the training of new colposcopists and for the continuing education and reorientation of those who are more experienced. This manual offers a valuable learning resource, incorporating recent developments in the understanding of the etiology and pathogenesis of cervical intraepithelial neoplasia (CIN), as well as in colposcopy and cervical pathology. Expertise in performing satisfactory, safe, and accurate colposcopic examinations requires high competence in the technical, interpretive, and cognitive aspects, and the capability to develop pragmatic and effective management plans and treatment. This comprehensive and concise manual covers all these aspects and serves as a useful handbook for acquiring the necessary skills for the visual recognition and interpretation of colposcopic findings and for developing the personal and professional attributes required for competence in colposcopy.

Featuring more than 1700 clinical, pathological and surgical photographs, this atlas is a comprehensive reference guide to the diagnosis and management of numerous obstetrical and gynaecological disorders. Divided into two sections (obstetrics and gynaecology), each section is further divided into sub sections covering key clinical aspects and disorders in each of the disciplines. Presented in an easy to read three column format throughout, each topic provides high quality photographs with a concise, clinical description, and management techniques. Each chapter includes ‘Evidence based breakthrough facts’ with source details, for further research. Key points Comprehensive reference to diagnosis and management of obstetrical and gynaecological disorders Features more than 1700 full colour clinical, pathological and surgical photographs and illustrations Easy to read, three column format Evidence based breakthrough facts with source included in each chapter

The first modern text describing the histopathologic changes relevant to the practice of forensic pathology.