This issue of Clinics in Chest Medicine focuses on Sepsis. Articles include: The changing epidemiology and definition of sepsis; risk stratification and prognosis in sepsis: what have we learned from biomarkers and microarrays?;Sepsis outside the ICU: development and implementation of sepsis alert systems; The use of ultrasound in caring for the septic patient; Sepsis resuscitation: Fluid choice and dose; Beyond the golden hours: caring for the septic patient after the initial resuscitation; Vasopressors during sepsis: selection and targets; Dysglycemia and glucose control during sepsis; Cardiac function and dysfunction in sepsis;Goal Directed Resuscitation in Septic Shock; and more!

This issue of Clinics in Chest Medicine, guest-edited by Dr. Margaret Pisani, is focused on Gender and Respiratory Disease. Topics discussed in this issue include but are not limited to: What are sex and gender and how can we study their impact in respiratory disease?, Sex differences in respiratory physiology, Impact of gender on social determinants of health, Gender differences in obstructive sleep apnea, Impact of gender on sleep disorders across the lifespan, Differences between men and women with COPD, Women and Lung Cancer, Pulmonary considerations in pregnant women and Asthma in women-gender specific considerations.

This issue of Clinics in Chest Medicine, edited by Dr. Michael Niederman, focuses on Pneumonia, with topics including: Inflammation and Pneumonia; The Lung Microbiome's Role in Pneumonia; Biomarkers for the Management of Pneumonia; Influenza and Viral Pneumonia; Guidelines to Manage Community-Acquired Pneumonia (CAP); Vaccines to Prevent CAP; Adjunctive Therapies for CAP; Healthcare Associated Pneumonia; Rapid Diagnostic Methods for Pneumonia; Airway Devices in VAP Pathogenesis and Prevention; Management of VAP; Distinguishing Ventilator-Associated Tracheobronchitis from VAP; Practical Approaches to VAP Prevention; Optimizing Antibiotic Administration for Pneumonia; New Antibiotics for Pneumonia; and Personalized Approach to Pneumonia Management.

This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.

This issue of Clinics in Chest Medicine focuses on Sarciodosis. Drs. Baughman and Culver have put together an expert roster of authors for articles concerning: Etiology of sarcoidosis, Immunology of sarcoidosis, Genetics of Sarcoidosis, Diagnosis of sarcoidosis, Chest imaging, Biomarkers and genetic profiles, Pulmonary Sarcoidosis, Neurosarcoidosis, Cardiac Sarcoidosis, Ocular Sarcoidosis, Quality of life assessments, and more!

In this issue, guest editors bring their considerable expertise to this important topic.Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

In this issue of Clinics in Chest Medicine, guest editors Drs. Eddy Fan, Shannon M. Fernando, and Sarina Sahetya bring their considerable expertise to the topic of Acute Respiratory Distress Syndrome. Top experts discuss environmental risk factors for ARDS; genetic and molecular risk factors for ARDS; biomarkers of ARDS; cellular mechanisms of lung injury; ARDS phenotypes and precision medicine; and more. - Contains 19 relevant, practice-oriented topics including prone positioning; steroids and immunomodulatory therapy for ARDS; early rehabilitation in ARDS; extracorporeal support for ARDS; long-term outcomes/PICS after ARDS; ARDS in the immunocompromised patient; future directions; and more. - Provides in-depth clinical reviews on acute respiratory distress syndrome, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Clinics in Chest Medicine is Guest Edited by Peter J. Barnes FRS, FMedSci from Imperial College London and will fosus on COPD. Article topics include epidemiology, pathophysiology, cellular and molecular mechanisms and comorbidities of COPD, diagnosis and phenotype of COPD, pulmonary rehabilitation, asthma and COPD, biomarkers, bronchodilators, non invasive ventialtion, and new drug therapies.

Drs. Robert Kotloff and Francis McCormack have assembled an expert team of authors on the topic of Rare and Orphan Lung Diseases. Articles include: Lymphangioleiomyomatosis, Pulmonary Lymphangiomatosis, Langerhans Cell Histiocytosis and other Histiocytic Diseases of the Lung, Pulmonary Alveolar Proteinosis, Pulmonary Alveolar Microlithiasis, Primary Ciliary Dyskinesia, Birt-Hogg-Dube Syndrome, Hermansky-Pudlak Syndrome, Hereditary Hemorrhagic Telangiectasia, Non-CF Bronchiectasis, Eosinophilic Lung Diseases, Benign Metastasizing Leiomyomata, and more!

This issue of Clinics in Chest Medicine is Guest Edited by Kristina Crothers, MD from the University of Washington and will focus on HIV and Respiratory Disease. Article topics include Abnormalities in Host Defense, Antiretroviral Therapy and Lung Immunology, HIV associated Pneumonia, HIV associated Tuberculosis, HIV associated lung malignancies, and HIV associated COPD.