This issue of Clinics in Chest Medicine focuses on Pulmonary Complications of Non-Pulmonary Malignancy. Editors Guang-Shing Cheng and Jennifer Possick have assembled an expert team of authors on topics such as: Pulmonary manifestations of non-pulmonary solid malgnancies; Pulmonary manifestations of leukemia and lymphoma; Radiation pneumonitis; Toxicities from conventional chemotherapy; Toxicities from novel targeted therapies; Bacterial pneumonia; Fungal pneumonia; Viral pneumonia; IPS and other early onset non-infectious pulmonary syndromes; Pulmonary GVHD and other late-onset non-infectious pulmonary syndromes; Pulmonary function and pre-transplant risk assessment; Diagnostic Evaluation of Pulmonary Abnormalities in Hematologic Malignancy and HCT; Acute respiratory failure in patients with non-pulmonary malignancy; Critical care prognosis and outcomes in patients with non-pulmonary malignancy; and Palliative and end-of-life care.

This issue of Clinics in Chest Medicine focuses on Pulmonary Complications of Non-Pulmonary Malignancy. Editors Guang-Shing Cheng and Jennifer Possick have assembled an expert team of authors on topics such as: Pulmonary manifestations of non-pulmonary solid malgnancies; Pulmonary manifestations of leukemia and lymphoma; Radiation pneumonitis; Toxicities from conventional chemotherapy; Toxicities from novel targeted therapies; Bacterial pneumonia; Fungal pneumonia; Viral pneumonia; IPS and other early onset non-infectious pulmonary syndromes; Pulmonary GVHD and other late-onset non-infectious pulmonary syndromes; Pulmonary function and pre-transplant risk assessment; Diagnostic Evaluation of Pulmonary Abnormalities in Hematologic Malignancy and HCT; Acute respiratory failure in patients with non-pulmonary malignancy; Critical care prognosis and outcomes in patients with non-pulmonary malignancy; and Palliative and end-of-life care.

This major reference work is the most comprehensive resource on oncologic critical care. The text reviews all significant aspects of oncologic ICU practices, with a particular focus on challenges encountered in the diagnosis and management of the critically ill cancer patient population. Comprised of over 140 chapters, the text explores such topics as the organization and management of an oncologic ICU, diseases and complications encountered in the oncologic ICU, multidisciplinary care, surgical care, transfusion medicine, special patient populations, critical care procedures, ethics, pain management, and palliative care. Written by worldwide experts in the field, Oncologic Critical Care is a valuable resource for intensivists, advance practice providers, nurses, and other healthcare providers, that will help close significant knowledge and educational gaps within the realm of medical care for critically ill cancer patients.

Drs. Robert Kotloff and Francis McCormack have assembled an expert team of authors on the topic of Rare and Orphan Lung Diseases. Articles include: Lymphangioleiomyomatosis, Pulmonary Lymphangiomatosis, Langerhans Cell Histiocytosis and other Histiocytic Diseases of the Lung, Pulmonary Alveolar Proteinosis, Pulmonary Alveolar Microlithiasis, Primary Ciliary Dyskinesia, Birt-Hogg-Dube Syndrome, Hermansky-Pudlak Syndrome, Hereditary Hemorrhagic Telangiectasia, Non-CF Bronchiectasis, Eosinophilic Lung Diseases, Benign Metastasizing Leiomyomata, and more!

This issue of Clinics in Chest Medicine focuses on Viral and Atypical Pneumonia. Editors Charles Dela Cruz and Richard Wunderlink have assembled an expert team of authors on topics such as: Epidemiology of Viral Pneumonia; Diagnostic Testing for Viral and Atypical Infections;Lung Microbiome: Atypical Infections and Viruses; RSV Pneumonia in the Young and Old;Viral infections in Chronic Lung Diseases; Viral Pneumonia and ARDS;Viruses in the Immunocompromised; Atypical Bacterial Pneumonia; Other Community Respiratory Viruses; Pandemic Viruses; Epidemic and Emerging Coronaviruses; Post-Viral Complications; Antiviral Treatments; and Vaccines in the Prevention of Viral Pneumonia.

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

This issue of Clinics in Chest Medicine, guest-edited by Dr. M. Patricia Rivera, is the second of two issues focused on Lung Cancer. Topics discussed in this issue include but are not limited to: Lung Cancer TNM Staging: The 8th Edition; New Surgical Approaches in the Treatment of NSCLC; Alternatives to Surgery for Early Stage Non-Small Cell Lung Cancer: Stereotactic Radiotherapy; Alternatives to Surgery for Early Stage Non-Small Cell Lung Cancer: Thermal Ablation; Advances in the Treatment of Stage III NSCLC; Advances in Treatment of NSCLC: Targeted Therapy; Advances in the Treatment of NSCLC: Immunotherapy; Treatment of Oligometastatic Disease in NSCLC; Management of Malignant Pleural Effusions; Advances in the Treatment of Small Cell Lung Cancer; Palliative Care and the Role of the Primary Care Physician in Lung Cancer Care; Pulmonary Complications of Immunotherapy; and Pulmonary Complications of Chemotherapy and Radiation Therapy.

This issue of Clinics in Chest Medicine focuses on Advances in Mechanical Ventilation. Articles include: Mechanical Ventilation Design Features; Assessing Respiratory System Mechanical Function; Ventilator Induced Lung Injury; Managing Acute Lung Injury; Patient-Ventilator Interactions; Extracorporeal Gas Exchange; Preventing Ventilator Associated Infections; Ventilator Discontinuation Process; Ventilator Management of the Non-injured Lung; Non-invasive Ventilation; and more!

This issue of Clinics in Chest Medicine is Guest Edited by Kristina Crothers, MD from the University of Washington and will focus on HIV and Respiratory Disease. Article topics include Abnormalities in Host Defense, Antiretroviral Therapy and Lung Immunology, HIV associated Pneumonia, HIV associated Tuberculosis, HIV associated lung malignancies, and HIV associated COPD.

Carcinoma of the lung is one of the most prevalent and aggressive types of cancer, and rates of lung cancer are on the rise. This issue gives a comprehensive review of the most recent advances in Lung Cancer. Epidemiology, etiology, and prevention of lung cancer is first discussed, followed by articles on pre-invasive evaluation and management, screening, pathology and molecular biology. There is an article on the approach to the ground glass nodule. Of great importance is the revised staging classification of Lung Cancer, which is discussed here in detail. Articles on PET imaging, interventional pulmonary, and functional evaluation before Lung Resection are also included. The issue then focuses on advances in treatment for early stage lung cancer, high risk patients with early stage lung cancer, advances in the treatment of Advanced Stage Lung Cancer, Small Cell Lung Cancer, and gene therapy for lung neoplasms.