At last, a much-needed route map to pediatric neuropathology. Up to now a comprehensive volume covering of pediatric neuropathology simply did not exist. This atlas is thus a unique, all-encompassing reference providing material on the fundamentals of brain disorders of the nervous system that can affect fetuses, infants and young children, as well as the essentials of diagnosis in developmental brain pathology and neuroimaging. Emphasising the characteristic morphology and a concise summary of clinical features, pathogenesis, and genetics, the generously illustrated atlas presents more than 100 disorders. This compilation is a valuable resource for pathologists, pediatric neurologists and neurosurgeons, geneticists, neonatologists, radiologists, and pediatricians.

I was gratified by the most favorable reception and wide usage received by the first edition of this book. A decade seems to be a short period for a book on pathology, and yet it witnessed many important changes of concepts, along with a formidable growth of knowledge. The second edition required extensive reorganization. There are new chapters on mitochondriopathies, on peroxisomal diseases and on spongy myelino pathies. Major revisions and new additions were necessary in many chapters, for instance those on the dysplasias of the cerebral and of the cerebellar hemispheres, which were largely reorganized. The chapters on perinatal pathology were reordered and reorganized to give a more logical sequence of prenatal, perinatal and postnatal lesions. The entire text was worked over for brevity. A wealth of new references was added with the. aim of staying abreast with the literature up to summer 1988. All refer ences were double checked for errors. My gratitude goes to Mrs. Gisela Ropte and Mrs. Cynthia Bunker for their untiring, diligent help. As a result, this second edition is an essentially rewritten text. Advance in the prevention of human suffering is based on a thorough understand ing of the nature of disease. I hope that this text will continue to be of service in this behalf. Perhaps it may also reflect and foster the intellectual curiosity which makes the "reading of brains" so interesting an occupation. Gottingen, 1989 Reinhard L.

This sixth edition provides an overview of fetal and neonatal pathology through a system-based approach. This book contains new chapters on immunology, with a continued focus on molecular aspects of pathology in the perinatal setting. The general principles of perinatal pathology and their clinical situations are also discussed, along with specific pathological entities and their organ systems. Keeling’s Fetal and Neonatal Pathology, sixth edition aims to help the reader treat common problems through anatomical pathology findings and is relevant to practicing and trainee pathologists, obstetricians, maternal and fetal medicine specialists, neonatologists, and pediatricians.

This volume represents a collection of topics presented at the Tenth Annual Symposium of the Barrow Neurological Institute. No attempt is made to be comprehensive but rather an attempt is made to give adequate attention to the major important topics in this field. Neuro developmental biology, pathophysiology, and laboratory evaluation are discussed. Subjects include hypoxic ischemia, intraventricular hemorrhage, fetal neurosurgery, surgery of hydrocephalus, problems of apnea, ultrasound and CT imaging techniques, electrodiagnosis and ethical and economic issues. This volume will be of interest to neurologists and neurosurgeons in general, and especially to pediatric neurologists and neurosurgeons, and perinatologists. Richard A. Thompson, M.D. John R. Green, M.D. Stanley D. Johnsen, M.D. vii Contents Contributors v Preface vii Acknowledgments xi CHAPTER 1 Use of Fetal Neurosurgery for Experimental Studies of Structural and Functional Brain Development in Nonhuman Primates 1 Pasko Rakic and Patricia S. Goldman-Rakic CHAPTER 2 Pathogenesis of Perinatal Hypoxic-Ischemic Brain Damage 17 Robert C. Vannucci CHAPTER 3 Current Concepts of Pathophysiology of Perinatal Intraventricular Hemorrhage 41 Jan Goddard-Finegold CHAPTER 4 New Therapies for Asphyxia Neonatorum and Intraventricular Hemorrhage of the Premature 57 Gary W. Goldstein CHAPTER 5 Cranial Sonography and CT of the Infant 67 Diane S. Babcock ix x Contents CHAPTER 6 Cross-Sectional and Longitudinal Studies of Brain Stem Auditory-Evoked Potentials in High-Risk Infants 85 James J. Stockard, Janet E. Stockard, and Allen Merritt CHAPTER 7 Neurosurgery in Congenital Defects Other Than Hydrocephalus 111 Hector E.

The novel aim of this book is to illustrate the MR imaging features of the fetal and the neonatal brain by matching prenatal and postnatal images for a wide range of neurological abnormalities. The focus is on both conventional and advanced MR imaging techniques, including high-resolution MR autopsy of the fetal brain. During the past ten years, neuroradiological evaluation of the neonatal and the prenatal brain has advanced tremendously. However, even though they are intrinsically related, these two critical stages in brain development are usually studied and presented separately. In order to have a sound understanding of neonatal brain diseases, detailed knowledge of prenatal brain pathology is immensely helpful; conversely, knowledge of neonatal brain disease is a prerequisite for understanding many fetal brain lesions. Written by experts in the field, Perinatal Neuroradiology will be of value for neuroradiologists and pediatric radiologists, as well as obstetricians and neonatologists.

Topic Editor Dr. Ana Paula Abdala provided paid consultancy and received research funding from the private sector. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

The fourth edition of the classic reference in the field of fetal and neonatal pathology, this revised and updated book retains the overall format of previous editions, presenting the same practical approach to the examination of both fetuses and perinatal deaths. It provides essential clinical and pathophysiological information and discusses the pathogenesis of abnormalities as a basis for appropriate methods of investigation. While primarily addressing the morbid anatomist and histopathologist, it is also a valuable resource for obstetricians, neonatologists and paediatricians.

Unparalleled access to the entire central nervous system with over four hundred gross neuropathology images from adult and paediatric post-mortem tissues.

Neuropathology, a title in the Foundations in Diagnostic Pathology series, provides all of the latest and most essential information on neoplastic and non-neoplastic conditions of the central and peripheral nervous systems in a high-yield, easy-to-use format. Renowned expert Richard A. Prayson, MD, along with a premier group of neuropathologists, provides unparalleled, expert guidance on the evaluation and diagnosis of a broad spectrum of neuropathic entities using morphologic, immunohistochemical, and molecular genetic techniques. The consistent, practical format with a wealth of illustrations, at-a-glance boxes, and tables make this title ideal for quick reference. Obtain expert, practical guidance on each pathologic entity, including clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnosis, and prognostic and therapeutic considerations. Reference key information quickly and easily with a consistent, user-friendly format and at-a-glance boxes and tables throughout the text. Recognize all the nuances of how pathological lesions present through over 800 full-color illustrations. Practice with confidence and overcome your toughest challenges with advice from the top minds in neuropathology. Make optimal use of the latest approaches for diagnosing fat and air emboli, vascular diseases, trauma, congenital malformations, perinatal diseases and phacomatoses, demyelinating and dysmyelinating disorders, neurodegenerative diseases, infections, metabolic and toxic disorders, glial and non-glial tumors, skeletal muscle and peripheral nerve disorders, and more. Prepare for the future of neuropathology with a new information dedicated to neurotransmitters as they relate to diseases such as Parkinson's and the development of new drugs for these disorders. Apply the latest molecular diagnostic techniques to recognize tumor entities added to the most recent WHO classification of tumors of the central nervous system. Access the fully searchable text online at www.expertconsult.com, along with a downloadable image bank, illustrations, boxes, tables, and more.