The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) addresses classification and labelling of chemicals by types of hazards. It provides the basis for worldwide harmonization of rules and regulations on chemicals and aims at enhancing the protection of human health and the environment during their handling, transport and use by ensuring that the information about their physical, health and environmental hazards is available. The sixth revised edition includes, inter alia, a new hazard class for desensitized explosives and a new hazard category for pyrophoric gases; miscellaneous amendments intended to further clarify the criteria for some hazard classes (explosives, specific target organ toxicity following single exposure, aspiration hazard, and hazardous to the aquatic environment) and to complement the information to be included in section 9 of the Safety Data Sheet; revised and further rationalized precautionary statements; and an example of labelling of a small packaging in Annex 7.

This is a test guideline for testing for Acute Oral Tosxidity using the Acute Toxic Class Method.

This document provides a description of a Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment and guidance to how the system will work.

The OECD Due Diligence Guidance for Responsible Supply Chains in the Garment and Footwear Sector helps enterprises implement the due diligence recommendations contained in the OECD Guidelines for Multinational Enterprises along the garment and footwear supply chain.

This document sets out the objectives, organisational context, and plan for a Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures.

This document provides guidance for the testing of substances, and mixtures, classed as “difficult to test” for the purposes of determining their aquatic toxicity.

This detailed background review paper provides a summary of the relevant literature (up to September 2001) relevant to the standardisation and validation of the rodent uterotrophic bioassay.

Quantitative Structure-Activity Relationship (QSAR) for Pesticide Regulatory Purposes stems from the experience of the EC funded project DEMETRA. This project combined institutes involved in the regulatory process of pesticides, industries of the sector and scientists to develop and offer original software for the prediction of ecotoxicity of pesticides. Then to be used within the dossier preparation for pesticide registration. The basis of this book is more than three-years of research activities, discussions, studies and successful models. This experience represents a useful example not only for the case of pesticides, but also for the prediction of ecotoxicity and toxicity in general. QSAR is used to link a given property of a chemical compound with some features related to its structure. The theoretical toxicological, chemical and information technology aspects will be treated considering the regulatory issues. Innovative hybrid systems will be described, for the toxicity prediction of pesticides and related compounds, directly useful for pesticide evaluation within the Dossier preparation for pesticide registration. Five endpoints will also be discussed, addressing issues as standardisation, verification, validation, accessibility, reproducibility.The driving force for Quantitative Structure-Activity Relationship (QSAR) for Pesticide Regulatory Purposes is that all the issues of concern for end-users are analysed, discussed and solutions proposed further. An innovative feature is that, in order to offer powerful QSAR models, the book discusses and reports on integrated QSAR models, combined into a unique hybrid system.* Assesses the needs of regulators for pesticide approval and how these needs affect QSAR models* Combines theoretical discussion with practical examples, including five worked examples of hybrid systems* Refers to original software available through the internet

This document provides the second edition of Guidance Document 23 on Aqueous-Phase Aquatic Toxicity Testing of Difficult Test Chemicals.