This detailed background review paper provides a summary of the relevant literature (up to September 2001) relevant to the standardisation and validation of the rodent uterotrophic bioassay.

This detailed background review paper provides a summary of the relevant literature (up to September 2001) relevant to the standardisation and validation of the rodent uterotrophic bioassay. The rodent uterotrophic bioassay is being validated as part of the OECD Test Guidelines Programme. The rodent uterotrophic bioassay is based on the principle that the uterus is under the control of oestrogens to stimulate and maintain growth. If endogenous sources of this hormone are not available, the animal will require an exogenous source to initiate and/or restore uterine growth.

The Uterotrophic Bioassay is an in vivo short-term screening test. It is based on the increase in uterine weight or uterotrophic response. The Uterotrophic Bioassay relies for its sensitivity on an animal test system in which the ...

This document reviews the area of biodegradability testing in order to identify whether, in the light of scientific developments, there was a need to revise existing OECD Test Guidelines or to develop new Guidelines.

This review documents examines member country classification of substances and mixtures which in contact with water release toxic gases.

This document focuses on the health and environmental hazards of mixtures.

This detailed review document examines member country classification systems for reproductive toxicity.

This Monograph describes in detail the process of Test Guideline development, including the structure of the Test Guidelines Programme, the responsibilities of those involved and the procedures which should be followed.

This detailed review documents examines member country classification of substances and mixtures which cause respiratorytract irritation and corrosion.

This detailed review document examines member country hazard classification systems for specific target organ systemic toxicity following single or repeated exposure.