This volume is devoted to the synthesis, application, structure, and physicochemical properties of nitroazoles (five-membered aromatic compounds). The book is unique in providing the first comprehensive treatment of nitroazoles.

Molecular Modeling of the Sensitivities of Energetic Materials, Volume 22 introduces experimental aspects, explores the relationships between sensitivity, molecular structure and crystal structure, discusses insights from numerical simulations, and highlights applications of these approaches to the design of new materials. Providing practical guidelines for implementing predictive models and their application to the search for new compounds, this book is an authoritative guide to an exciting field of research that warrants a computer-aided approach for the investigation and design of safe and powerful explosives or propellants. Much recent effort has been put into modeling sensitivities, with most work focusing on impact sensitivity and leading to a lot of experimental data in this area. Models must therefore be developed to allow evaluation of significant properties from the structure of constitutive molecules. - Highlights a range of approaches for computational simulation and the importance of combining them to accurately understand or estimate different parameters - Provides an overview of experimental findings and knowledge in a quick and accessible format - Presents guidelines to implement sensitivity models using open-source python-related software, thus supporting easy implementation of flexible models and allowing fast assessment of hypotheses

Congress Proceedings

Contains synopses of scientific papers published in Yugoslavian periodicals.

This book summarizes science and technology of a new generation of high-energy andinsensitive explosives. The objective is to provide professionals with comprehensiveinformation on the synthesis and the physicochemical and detonation properties ofthe explosives. Potential technologies applicable for treatment of contaminated wastestreams from manufacturing facilities and environmental matrices are also be included.This book provides the reader an insight into the depth and breadth of theoreticaland empirical models and experimental techniques currently being developed in thefield of energetic materials. It presents the latest research by DoD engineers andscientists, and some of DoD’s academic and industrial researcher partners. The topicsexplored and the simulations developed or modified for the purposes of energetics mayfind application in other closely related fields, such as the pharmaceutical industry.One of the key features of the book is the treatment of wastewaters generated duringmanufacturing of these energetic materials.

Advances in Heterocyclic Chemistry, Volume 133 is the latest release in this definitive series of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review contains comprehensive chapters on Organosilicon azoles: Structure, silylotropy and NMR spectroscopy, Recent advances in the Nenitzescu indole synthesis (1990–2019), One-pot reactions of three-membered rings giving N,O,S-heterocycles, Organometallic complexes of functionalized chelating azines: Part 2, and more. Presents the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists Provides the latest comprehensive reviews as written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds

This book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The book offers a comprehensive overview of the most recent studied targets, and it outlines classical and new treatments and delivery strategies. Expert contributors describe new methods of analysis and bio-prospecting for new compounds, and provide a critical perspective of the translational process used in the research and development of new drug candidates. The book will appeal not only to researchers, students and professionals interested in drug development to protozoan diseases, but also to medicinal chemists in general.