This issue of Critical Care Clinics focuses on Mechanical Ventilation and Ventricular Assist Devices, with topics including: Targeted management approach to cardiogenic shock; Prevention and treatment of right heart failure during left ventricular assist device support therapy; Complications of durable left ventricular assist device support therapy; Patient and device management on left ventricular assist device support therapy; Challenges and future directions in left ventricular assist device support therapy; Monitoring global and regional mechanics; Asynchrony consequences and management; Determinants and prevention of ventilator-induced lung injury; Extracorporeal gas exchange; Non-invasive options; Mobilization and VIDD avoidance; Initiating and discontinuing invasive support; and Automation of ventilation.

This issue of Critical Care Clinics focuses on Mechanical Ventilation and Ventricular Assist Devices, with topics including: Targeted management approach to cardiogenic shock; Prevention and treatment of right heart failure during left ventricular assist device support therapy; Complications of durable left ventricular assist device support therapy; Patient and device management on left ventricular assist device support therapy; Challenges and future directions in left ventricular assist device support therapy; Monitoring global and regional mechanics; Asynchrony consequences and management; Determinants and prevention of ventilator-induced lung injury; Extracorporeal gas exchange; Non-invasive options; Mobilization and VIDD avoidance; Initiating and discontinuing invasive support; and Automation of ventilation.

This issue of Critical Care Clinics, edited by Mervyn singer and Manu Shankar-Hari, includes: Sepsis 3.0 Definitions; Epidemiology and Outcomes; Pathophysiology of sepsis; Pathophysiology of Septic shock; Mechanism of organ dysfunction in sepsis; Endocrine and metabolic alterations in sepsis: challenges and treatments; The immune system in sepsis; Nutrition and Sepsis; Common sense approach to managing sepsis; Biomarkers for sepsis and their use; Personalizing sepsis care; Novel interventions - What’s new and the future; and Long term outcomes following Sepsis.

This issue of Critical Care Clinics focuses on Rapid Response Systems and Fluid Resuscitation, with topics including: RRS Now; Triggering Criteria: Big Data; Triggering Criteria: Continuous Monitoring; Measuring instability; Surgery/Trauma RRT; Obstetric RRT; Difficult airway rapid response teams; and Sepsis rapid response teams.

This issue of Critical Care Clinics, Guest Edited by Dr. Rinaldo Bellomo, focuses on Modern Critical Care Endocrinology. Article topics include: Diabetes insipidus and SIADH in the ICU; Estrogen therapy in ICU patients; The angiotensin family, ACE and ACE 2; Angiotensin II in vasodilatory shock; Vasopressin in vasodilatory shock; Hydrocortisone in vasodilatory shock; Erythropoietin in trauma and critical illness; HbA1c and permissive hyperglycemia in diabetic ICU patients; Osteoporosis and the critically ill patient; New oral agents for the treatment of diabetes; Melatonin in critical care; The incretins in ICU patients; Hepcidin; Thyroid hormone therapy in the ICU; and Hormonal therapy in organ donors.

This issue of Critical Care Clinics focuses on Psychiatric Aspects of Critical Care Medicine. Editor Jose Maldonado has assembled an expert team of authors on topics such as: Psychiatric Aspects of Organ Transplantation in Critical Care; Medical Complications of Psychiatric Treatment; Psychiatric and Palliative Care in the ICU; Psychiatric Aspects of Heart and Lung Disease in Critical Care; Alcohol Withdrawal Syndromes: Assessment and Management; Substance Abuse and Withdrawal in the Critical Care Setting; Mood Disorders and The Outcome of Suicidal Thoughts and Attempts; Anxiety Disorders and the Outcomes of Trauma; Assessment and Management of Toxidromes in the Critical Care Unit; Neuropsychiatric Consequences of Trauma and Head Injury; Detection and Management of Pre-Existing Cognitive Impairment in the Critical Care Unit; Delirium: Pathophysiology, Diagnosis and Treatment; Neuropsychiatric Aspects of Infectious Processes.

In this issue of Critical Care Clinics, guest editors Drs. David N. Hager, Kyle Gunnerson, and Stephen Macdonald bring their considerable expertise to the topic of Critical Illness Outside the ICU. Top experts cover key topics such as flight transport of the critically ill; models of critical care in the emergency department; in-hospital triage; rapid response teams; early warning systems; ICU without walls; and more. - Contains 14 relevant, practice-oriented topics the role of intermediate care; PACU care; critical care in rural settings; critical care in austere settings; tele-ICU support; alternate care pathways for the patient with multimorbidity; and more. - Provides in-depth clinical reviews on critical illness outside the ICU, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Critical Care Clinics, guest edited by Drs. Marie Baldisseri, Mary Reed, and Randy Wax, in collaboration with Consulting Editor John Kellum, is devoted to Intensive Care Unit in Disaster. Topics in this issue include: Intensive care role in disaster management; Preparing the ICU for disaster; Augmenting capacity; Triage; Natural disasters; Biological/pandemic disasters; Chemical disasters; Radiation; Anthropogenic (terrorist/criminal act) disasters; Special populations (i.e., chronically ill, morbidly obese, pregnant); Pediatrics; Austere environments; Hospital as disaster Ground Zero; and Special considerations (i.e., mental health, ethics, public relations).

This issue of Critical Care Clinics edited by Dr. Margaret Parker on Pediatric Critical Care features topics such as:1. Acute Respiratory Failure, Post-op Cardiac Surgery, Septic Shock, Acute Renal Failure, Traumatic Brain Injury, Encephalitis, Status Asthmaticus, Status Epilepticus, Bleeding/coagulopathy, and Transfusion.

In this issue of Critical Care Clinics, guest editors Drs. Steven Hollenberg and José L. Diaz-Gomez bring their considerable expertise to the topic of Cardiovascular Intensive Care. Top experts cover key topics such as hemodynamic monitoring in the cardiac ICU; the role of ultrasound in the cardiac ICU; cardiogenic shock; management of patients after cardiac arrest; temporary mechanical circulatory support; and more. - Contains 16 relevant, practice-oriented topics including the changing epidemiology of the cardiac intensive care unit; diagnosis and management of LVAD emergencies; design and execution of clinical trials in the CICU; end-of life issues in patients with mechanical circulatory support; and more. - Provides in-depth clinical reviews on cardiovascular intensive care, offering actionable insights for clinical practice.Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.