A fast-paced, nerve-fraying contemporary thriller that questions loyalties and twists truths. Appearances can be deceiving. Lyla Hamilton is a loyal member of the Community. Her family was happy to be chosen by Pioneer to join such an lovely gated neighborhood. Here, life seems perfect. But after meeting Cody, an outsider boy, Lyla starts questioning Pioneer, her friends, her family--everything. And if there's one thing not allowed in the Community, it's doubt. As Pioneer cleverly manipulates his flock toward disaster, the real question is: Will Lyla follow her heart or follow Pioneer over the edge? From the outside looking in, it's hard to understand why anyone would join a cult. But Gated tells the story from the inside looking out, and from behind the gates things are not quite so simple. Amy Christine Parker's beautiful writing creates a chilling, utterly unique YA story. Perfect for fans of creepy thrillers and contemporary fiction alike. "A tense psychological thriller that will leave you gasping for breath as you race to the very last page." --Gretchen McNeil, author of Ten HelloGiggles.com, August 3, 2013: "When I found out that there was a YA book about cults, of course I had to read it. As it turns out, Amy Christine Parker’s Gated is an awesome, creepy book that reminds me of my favorite cult films while still being surprising." Starred Review, Kirkus Reviews, June 15, 2013: "Parker doesn’t pull punches, indicating a level of brutality that will appropriately disturb even as it successfully conveys Lyla’s complete entrapment in the Community. Compelling and not that distant from real-world cults that have ended in tragedy." Publishers Weekly, June 10, 2013: "Parker skillfully explores the mindset and inner workings of an apocalyptic cult, steadily building toward the inevitable moment of truth...As for the apocalypse itself, Parker keeps things suitably ambiguous, resulting in a complex, intriguing tale rooted in real-world events." School Library Journal, October 2013: "This well-plotted tale will allow readers a glimpse into the possible world of a doomsday cult...The language is accessible, making it a good choice for reluctant readers. After the last page is turned, the question will linger: 'Could I ever be deceived like this?'" Examiner.com "A well-rounded and thorough look into cults while still remaining entertaining throughout. I look forward to reading more of Parker's works in the future."

"Gated Communities" presents a collection of new writings by an international and interdisciplinary group of contributors, which provides a historic, socio-political and contemporary cultural perspective of gated communities.

This informative volume gathers contemporary accounts of the growth, influences on, and impacts of so-called gated communities, developments with walls, gates, guards and other forms of surveillance. While gated communities have become a common feature of the urban landscape in South Africa, Latin and North America, it is also clear that there is now significant interest in gated living in the European and East Asian urban context. The chapters in this book investigate issues and communities such as: gated communities in the metropolitan area of Buenos Aires, Argentina planning responses to gated communities in Canada who segregates whom? The analysis of a gated community in Mendoza, Argentina sprawl and social segregation in southern California. These illustrative chapters enable the reader to understand more about the social and economic forces that have lead to gating, the ways in which gated communities are managed, and their wider effects on both residents and those living outside the gates. This book was previously published as a special issue of the journal Housing Studies.

"This book will be useful for all physicians involved in cardiac imaging, whether they are in radiology, nuclear medicine, or cardiology, and should be mandatory for physicians engaged in gated cardiac SPECT. It is recommended without reservation." – from a review of the first edition in Radiology With gated cardiac SPECT now firmly established for the management of the cardiac patient, Drs. Germano and Berman bring you completely up to date with the multiple clinical applications as well as the recent technical developments of the modality. Clinical Gated Cardiac SPECT, Second Edition: covers all the available protocols describes a systematic approach for interpretation and reporting provides guidance for the recognition of artifacts includes flowcharts on the management of patients The relationship of gated cardiac SPECT to PET, MRI and CT is explored in separate chapters devoted to each modality. This book is essential reading for all clinicians involved in cardiac imaging.

Research on gated communities is moving away from the hard concept of a 'gated community' to the more fluid one of urban gating. The latter allows communities to be viewed through a new lens of soft boundaries, modern communication and networks of influence. The book, written by an international team of experts, builds on the research of Bagaeen and Uduku’s previous edited publication, Gated Communities (Routledge 2010) and relates recent events to trends in urban research, showing how the discussion has moved from privatised to newly collectivised spaces, which have been the focal point for events such as the Occupy London movement and the Arab Spring. Communities are now more mobilised and connected than ever, and Beyond Gated Communities shows how neighbourhoods can become part of a global network beyond their own gates. With chapters on Australia, Canada, Europe, South America, Asia, Africa and the Middle East, this is a truly international resource for scholars and students of urban studies interested in this dynamic, growing area of research.

This book examines the nature and dynamics of gated communities within the specificities of reform Shanghai, a city that arguably has been at the forefront of China’s new urban/consumer revolution.

It is our pleasure to co-edit a Research Topic on voltage-gated sodium channels pharmacology and related diseases. We are in a process to inviting submissions of novel research article, state-of-the-art review papers and viewpoints on this topic. All the papers will follow a peer-review process according to the guidelines of Frontiers in Pharmacology. Voltage-gated sodium channel play a critical role in electrical signalling in many excitable cells such as neurons, skeletal muscle cells and cardiac myocytes. They are responsible for the initiation and the propagation of action potential, allowing integration of higher processes. They are formed by one alpha subunit that forms the pore of the channel and one or several regulatory subunits. Sodium channels are the target for local anaesthetics, antiarrhythmic drugs, and anticonvulsants. This class of ion channels is prime target to several toxins. Recently, a number of mutations in sodium channels that often results in alterations of rapid channel gating have been identified and linked to human diseases. Such channelopathies cause periodic paralysis, myotonia, long QT syndrome and other cardiac conductance disturbances, pain, hemiplegic migraine, and epilepsy. Sodium channels play also a negative role in malignant cellular proliferation, chronic pain, and other diseases. Considering these crucial physiological and pathological implications, it is not surprising that sodium channels have been and still are key targets for drug development. This Research Topic of Frontiers of Pharmacology of Ion Channels and Channelopathies will focus on this important class of ion channels how they operate, their pharmacology and their implication in diseases.

This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.

The aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.

Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therapeutic interventions. Diverse molecular and cellular mechanisms have been identified for P2X receptor functioning, including the ability to enlarge the size of the ion pore associated with the release of several key immune molecules. A major recent breakthrough was the determination of the X-ray crystal structures of zebrafish P2X4 receptor in ATP-bound and ATP-free states. The P2X receptor research field is rapidly growing, as evidenced by the almost 2000 papers published in the last 5 years. However, despite the fundamental signalling function of extracellular ATP in the nervous system, the widespread roles of P2X receptors have not been widely elucidated and presented in textbooks. In this volume of papers we aim to gather a collection of high quality papers, detailing the latest insights from the most accomplished international P2X receptor researchers. Importantly, basic research into P2X receptors has a strong translational impact and our collection of articles could be a valuable guide for the development of new pharmacological and biotechnological tools addressing the function of P2X receptors. Within this collection we plan to cover receptor structure-function relationships, receptors trafficking, to highlight the special properties of P2X receptors and their pharmacological profiles, and to describe the translational aspects of cellular ATP signaling in pain and in other neurological and vascular diseases.