Voltage Gated Calcium Channels
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Author |
: Hugo J. Bellen |
Publisher |
: Oxford University Press, USA |
Total Pages |
: 466 |
Release |
: 1999 |
ISBN-10 |
: UOM:39015048547338 |
ISBN-13 |
: |
Rating |
: 4/5 (38 Downloads) |
Synopsis Neurotransmitter Release by : Hugo J. Bellen
This book provides the reader with background information on neurotransmitter release. Emphasis is placed on the rationale by which proteins are assigned specific functions rather than just providing facts about function.
Author |
: Gerald Werner Zamponi |
Publisher |
: Springer Nature |
Total Pages |
: 705 |
Release |
: 2022-11-07 |
ISBN-10 |
: 9783031088810 |
ISBN-13 |
: 3031088816 |
Rating |
: 4/5 (10 Downloads) |
Synopsis Voltage-Gated Calcium Channels by : Gerald Werner Zamponi
This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.
Author |
: |
Publisher |
: Academic Press |
Total Pages |
: 307 |
Release |
: 2013-07-24 |
ISBN-10 |
: 9780124079380 |
ISBN-13 |
: 0124079385 |
Rating |
: 4/5 (80 Downloads) |
Synopsis Store-Operated Calcium Channels by :
Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. - The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels - Contributors are authoritative researchers who have produced important advances in the field - The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject
Author |
: Richard W. Tsien |
Publisher |
: |
Total Pages |
: 420 |
Release |
: 1998 |
ISBN-10 |
: UOM:39015047707891 |
ISBN-13 |
: |
Rating |
: 4/5 (91 Downloads) |
Synopsis Low-voltage-activated T-type Calcium Channels by : Richard W. Tsien
Author |
: Fatima Shad Kaneez |
Publisher |
: BoD – Books on Demand |
Total Pages |
: 204 |
Release |
: 2018-10-10 |
ISBN-10 |
: 9781789842272 |
ISBN-13 |
: 1789842271 |
Rating |
: 4/5 (72 Downloads) |
Synopsis Ion Channels in Health and Sickness by : Fatima Shad Kaneez
Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.
Author |
: Jeffrey Noebels |
Publisher |
: OUP USA |
Total Pages |
: 1258 |
Release |
: 2012-06-29 |
ISBN-10 |
: 9780199746545 |
ISBN-13 |
: 0199746540 |
Rating |
: 4/5 (45 Downloads) |
Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey Noebels
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Author |
: Juliusz Ashot Kozak |
Publisher |
: CRC Press |
Total Pages |
: 343 |
Release |
: 2017-07-14 |
ISBN-10 |
: 9781498752732 |
ISBN-13 |
: 149875273X |
Rating |
: 4/5 (32 Downloads) |
Synopsis Calcium Entry Channels in Non-Excitable Cells by : Juliusz Ashot Kozak
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Author |
: David J. Triggle |
Publisher |
: John Wiley & Sons |
Total Pages |
: 492 |
Release |
: 2006-08-21 |
ISBN-10 |
: 9783527607747 |
ISBN-13 |
: 3527607749 |
Rating |
: 4/5 (47 Downloads) |
Synopsis Voltage-Gated Ion Channels as Drug Targets by : David J. Triggle
Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.
Author |
: Peter C. Ruben |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 328 |
Release |
: 2014-04-15 |
ISBN-10 |
: 9783642415883 |
ISBN-13 |
: 3642415881 |
Rating |
: 4/5 (83 Downloads) |
Synopsis Voltage Gated Sodium Channels by : Peter C. Ruben
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Author |
: Kim Heidenreich |
Publisher |
: Academic Press |
Total Pages |
: 354 |
Release |
: 2016-09-27 |
ISBN-10 |
: 9780128027011 |
ISBN-13 |
: 0128027010 |
Rating |
: 4/5 (11 Downloads) |
Synopsis New Therapeutics for Traumatic Brain Injury by : Kim Heidenreich
New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury. Comprehensive overview of basic approaches and translational development of new therapies for TBI Edited by a prominent TBI researcher that includes contributions by leading global researchers in the field Presents a great resource for researchers and practitioners to learn more about the many evolving preclinical studies and clinical trials currently underway, and the challenges of bringing translational studies in TBI to the clinic