The story of a neural impulse and what it reveals about how our brains work We see the last cookie in the box and think, can I take that? We reach a hand out. In the 2.1 seconds that this impulse travels through our brain, billions of neurons communicate with one another, sending blips of voltage through our sensory and motor regions. Neuroscientists call these blips “spikes.” Spikes enable us to do everything: talk, eat, run, see, plan, and decide. In The Spike, Mark Humphries takes readers on the epic journey of a spike through a single, brief reaction. In vivid language, Humphries tells the story of what happens in our brain, what we know about spikes, and what we still have left to understand about them. Drawing on decades of research in neuroscience, Humphries explores how spikes are born, how they are transmitted, and how they lead us to action. He dives into previously unanswered mysteries: Why are most neurons silent? What causes neurons to fire spikes spontaneously, without input from other neurons or the outside world? Why do most spikes fail to reach any destination? Humphries presents a new vision of the brain, one where fundamental computations are carried out by spontaneous spikes that predict what will happen in the world, helping us to perceive, decide, and react quickly enough for our survival. Traversing neuroscience’s expansive terrain, The Spike follows a single electrical response to illuminate how our extraordinary brains work.

A unified treatment of the generation and analysis of brain-generated electromagnetic fields. In Brain Signals, Risto Ilmoniemi and Jukka Sarvas present the basic physical and mathematical principles of magnetoencephalography (MEG) and electroencephalography (EEG), describing what kind of information is available in the neuroelectromagnetic field and how the measured MEG and EEG signals can be analyzed. Unlike most previous works on these topics, which have been collections of writings by different authors using different conventions, this book presents the material in a unified manner, providing the reader with a thorough understanding of basic principles and a firm basis for analyzing data generated by MEG and EEG. The book first provides a brief introduction to brain states and the early history of EEG and MEG, describes the generation of electromagnetic fields by neuronal activity, and discusses the electromagnetic forward problem. The authors then turn to EEG and MEG analysis, offering a review of linear and matrix algebra and basic statistics needed for analysis of the data, and presenting several analysis methods: dipole fitting; the minimum norm estimate (MNE); beamforming; the multiple signal classification algorithm (MUSIC), including RAP-MUSIC with the RAP dilemma and TRAP-MUSIC, which removes the RAP dilemma; independent component analysis (ICA); and blind source separation (BSS) with joint diagonalization.

What is as unique as your fingerprints and more revealing than your diary? Hint: Your body is emitting them right now and has been every single day of your life. Brainwaves. Analyzing brainwaves, the imperceptible waves of electricity surging across your scalp, has been possible for nearly a century. But only now are neuroscientists becoming aware of the wealth of information brainwaves hold about a person's life, thoughts, and future health. From the moment a reclusive German doctor discovered waves of electricity radiating from the heads of his patients in the 1920s, brainwaves have sparked astonishment and intrigue, yet the significance of the discovery and its momentous implications have been poorly understood. Now, it is clear that these silent broadcasts can actually reveal a stunning wealth of information about any one of us. In Electric Brain, world-renowned neuroscientist and author R. Douglas Fields takes us on an enthralling journey into the world of brainwaves, detailing how new brain science could fundamentally change society, separating fact from hyperbole along the way. In this eye-opening and in-depth look at the most recent findings in brain science, Fields explores groundbreaking research that shows brainwaves can: • Reveal the type of brain you have—its strengths and weaknesses and your aptitude for learning different types of information • Allow scientists to watch your brain learn, glean your intelligence, and even tell how adventurous you are • Expose hidden dysfunctions—including signifiers of mental illness and neurological disorders • Render your thoughts and transmit them to machines and back from machines into your brain • Meld minds by telepathically transmitting information from one brain to another • Enable individuals to rewire their own brains and improve cognitive performance Written by one of the neuroscientists on the cutting edge of brainwave research, Electric Brain tells a fascinating and obscure story of discovery, explains the latest science, and looks to the future—and the exciting possibilities in store for medicine, technology, and our understanding of ourselves.

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The individual chapters cover several fascinating facets of contemporary neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Each of these topics require appropriate levels of analyses with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks, supplemented by models and theories to explain how different levels of brain dynamics interact with each other and how the failure of such interactions results in neurologic and mental disease. While such complex questions cannot be answered exhaustively by a dozen or so chapters, this volume offers a nice synthesis of current thinking and work-in-progress on micro-, meso- and macro- dynamics of the brain.

Leading neuroscience researchers are racing to unlock the secrets of the mind. On the cusp of decoding brain signals that govern motor skills, they are developing miraculous technologies that will enable paraplegics and wounded soldiers to move prosthetic limbs and will give all of us the power to manipulate computers and other objects through thought alone. These fiercely competitive scientists are vying for government and venture capital funding, prestige, and wealth. Part life-altering cure, part science fiction, part Defense Department dream, these cutting edge brain-computer interfaces promise to improve lives-but they also hold the potential to augment soldiers' combat capabilities. In The Brain Electric, Malcolm Gay follows the dramatic emergence of these technologies, taking us behind the scenes in operating rooms, startups, and research labs, where the future is unfolding. With access to many of the field's top scientists, Gay illuminates this extraordinary race-where science, medicine, profit, and war converge-for the first time. But this isn't just a story about technology. At the heart of the scientists' research is a group of brave patient-volunteers, whose lives are given new meaning through these experiments. The Brain Electric asks us to rethink our relationship to technology, our bodies, even consciousness itself, challenging our assumptions about what it means to be human.

Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel

It is common to study the electric activity of neurons by measuring the electric potential in the extracellular space of the brain. However, interpreting such measurements requires knowledge of the biophysics underlying the electric signals. Written by leading experts in the field, this volume presents the biophysical foundations of the signals as well as results from long-term research into biophysics-based forward-modeling of extracellular brain signals. This includes applications using the open-source simulation tool LFPy, developed and provided by the authors. Starting with the physical theory of electricity in the brain, this book explains how this theory is used to simulate neuronal activity and the resulting extracellular potentials. Example applications of the theory to model representations of real neural systems are included throughout, making this an invaluable resource for students and scientists who wish to understand the brain through analysis of electric brain signals, using biophysics-based modeling.

A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid

Intended for use by advanced undergraduate, graduate and medical students, this book presents a study of the unique biochemical and physiological properties of neurons, emphasising the molecular mechanisms that generate and regulate their activity.