This book shares an expert experience in managing difficult facial skin cancer and presents rare cases from the authors's own practice. The content follows an anatomical approach based on the complex and often staged reconstruction of extreme facial skin cancer. Written in a clear and logical format, it is intended as a guideline atlas and surgical handbook, defining the principles of CLEAR (Complete Local Excision of the cancer + Aesthetic Reconstruction) and DRAPE (Delayed Reconstruction After Pathological Examination) for reconstructing the face. The book incorporates a wealth of multi-disciplinary knowledge from surgeons, anaesthetists, research scientists, speech / swallowing therapists, pathologists, radiologists and prosthetic rehabilitation specialists. The surgical techniques presented here require a high degree of expertise. Accordingly, the book will be of interest to professionals in the fields of Plastic and Oral and Maxillofacial Surgery, as well as Dermatology.

Worldwide, it is quoted that 85% of Melanoma cases are treated surgically. The reliability of the Keystone Perforator Island Flap (KPIF) as a reconstructive technique has wide applications. Its low complication rate is the key to its surgical success. The technique is clearly explained in this Atlas by the author, a renowned plastic and reconstructive surgeon, who established this reconstructive principle over 20 years. The illustrations range from simple to complex cases in an easy-to-follow format. Audio files, as a supplementary tool, amplify the technique to enhance the reader’s experience and foster clear understanding. Chapters focussing on anatomical regions contain carefully selected cases accompanied by images to demonstrate a step-by-step surgical technique. The basic design format for all Keystones are highlighted, all sitting within the dermatomal precincts. The KPIF must contain a fascial base for lining and the island outline is an essential pre-requisite. It is hypothesized that this islanding creates a sympathectomy effect resulting in hyperaemic blood flow which optimises healing. Undermining up to 2/3 is permissible as long as there is a deep attachment of 1/3 at the base of the flap to contain the random perforator vascular support. This design allows the rotation, advancement and transposition (ART) of the flap to facilitate the reconstructive closures. Presumably, there are somatic and autonomic neural support lines accompanying the vascular pathways of these random perforator flaps. The vascular perforator tree must not be skeletonised (as in propellor flaps) to allow preservation of such anatomical elements - somatic, autonomic and lymphatic pathways, all of which are an essential component in any surgical repair. This KPIF provides an alternative to microvascular procedures where the biggest drawback is tissue match. The KPIF addresses this problem admirably with a low pain component, an excellent aesthetic match with a low vascular complication rate and a performed in an expeditious manner – these all characterise the KPIF. Simple solutions solve problems and this KPIF Atlas for Melanoma becomes a welcome companion to any surgical speciality including plastic and reconstructive surgeons, surgical oncologists, general surgeons and dermatologists.

This book of the series on “Advances in Biochemistry in Health and Disease” includes state-of-the-art information on the status of renin-angiotensin system (RAS) in the form of 24 chapters. This book has been organized into three sections: (i) General Implications of RAS in human health and Infectious Diseases, (ii) Lung, Liver and Kidney Diseases, and (iii) Development of Cancer. Each chapter has discussed comprehensive knowledge regarding the molecular and cellular aspects of the role of RAS in the pathophysiology and pharmacotherapy of different disease processes. Biochemical mechanisms associated with angiotensin II type 1 and type II receptors, and angiotensin (1-7) MAS receptors for the occurrence of both harmful and beneficial effects of prolonged activation of RAS in different diseases have been outlined. It is noteworthy to point out that different chapter in this book were prepared by recognized global expertise in the area of inflammation, oxidative stress and signal transduction pathways to highlight the role of RAS in different diseases. It is our sincere hope that this book will be of great interest to both biomedical investigators and health professionals as well as graduate students and postdoctoral fellows all over the world.

This atlas illustrates the latest available data on the cancer epidemic, showing causes, stages of development, and prevalence rates of different types of cancers by gender, income group, and region. It also examines the cost of the disease, both in terms of health care and commercial interests, and the steps being taken to curb the epidemic, from research and screening to cancer management programs and health education.

For the third edition, the text has been thoroughly revised to keep pace with new concepts in oral medicine. The structure of the text has been clarified and made more practically useful, with references to etiology, clinical images, differential diagnosis, laboratory diagnostic tests, and therapy guidelines. Also new in the third edition: four new chapters, and more than 240 new, exquisite illustrations of lesions and pathologic conditions affecting the oral cavity.

A lavishly illustrated guide to almost 200 inherited diseases of the skin, hair, and nails. Each entry includes synonyms, age of onset, clinical findings, complications, course, laboratory findings, diagnosis, therapy, and key references, adding up to far more than just a collection of photographs. In addition to being a clinical primer, this is also a work of scientific research and contains the first printed description of two new syndromes. The fast-moving world of genetic research means that the latest genetic correlations, included here, render previous texts out of date. All specialists in Dermatology and Pediatrics should find this an invaluable front-line resource in the clinic.

In the early 20th century, tanned skin was associated with good health. However, people began to protect themselves against potential overexposure to avoid sunburns. Around 1945, the first sunscreen products became available. In the years to follow, a vast number of different sunscreen filters and frameworks regulating filter substances and preparations, and methods characterizing sunscreen products were developed. The perception regarding the tasks of sunscreen products changed several times – initially it was promoted as a lifestyle product, then as a skin cancer preventive means, and more recently also for anti-aging. Different purposes and the widespread use of these products have led to myriad studies and a wealth of information. In this volume, the editors present a current collection of information analyzing and discussing issues related to sunscreen products and their use. These include challenges regarding the ideal sunscreen product including filter selection and formulation issues, measurement methods, performance characterization, safety, and regulatory issues. Further papers address topics related to the use of sunscreen products in everyday life, in vulnerable cohorts and outdoor workers. Controversial topics such as environmental effects of sunscreen products and the risks and benefits of UV radiation in the context of skin cancer, vitamin D and cardiovascular and metabolic health are also covered.

Mohs surgery is microscopically controlled surgery used to treat common types of skin cancer and allows for the removal of a skin cancer with a very narrow surgical margin and a high cure rate. However, for those involved with the Mohs procedure, it is critical to understand the optimal preparation and interpretation of frozen sections. Complete with hundreds of high resolution figures, Atlas of Practical Mohs Histopathology is written by leading experts in the field and discusses everything from normal skin histology and rare tumors to pitfalls and incidental findings. Dermatologic surgeons, Mohs cutaneous surgeons, dermatopathologists and pathologists alike will find this book to be a comprehensive and indispensable reference.

Filling a gap in the present inventory of Plastic Surgery Textbooks, this compact, practice-oriented study guide delivers comprehensive, clear and up-to-date information on all the basics of plastic surgery in clinical practice. Methodological rigor, together with a lean style and layout were chosen; boxes and teaching objectives are included to help memorize fundamentals. Starting from basics such as the physiology and pathology of skin and wound healing, suture techniques, dressings and dermal substitutes, grafts, flaps and microsurgical techniques, the textbook then tackles topics including malformations, skin cancer, and traumas like burns and wounds. The respective contributions were written by American, British, Italian, German, Korean and Taiwanese teaching experts in the field. Over 250 full color illustrations, line drawings, and videos support the main text: accordingly, this textbook will appeal to advanced, upper-undergraduate students and residents preparing for plastic and reconstructive surgery in-training.