The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.

The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.

The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.

The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.

The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.

This book combines the advantages of high-dimensional data visualization and machine learning in the context of identifying complex n-D data patterns. It vastly expands the class of reversible lossless 2-D and 3-D visualization methods, which preserve the n-D information. This class of visual representations, called the General Lines Coordinates (GLCs), is accompanied by a set of algorithms for n-D data classification, clustering, dimension reduction, and Pareto optimization. The mathematical and theoretical analyses and methodology of GLC are included, and the usefulness of this new approach is demonstrated in multiple case studies. These include the Challenger disaster, world hunger data, health monitoring, image processing, text classification, market forecasts for a currency exchange rate, computer-aided medical diagnostics, and others. As such, the book offers a unique resource for students, researchers, and practitioners in the emerging field of Data Science.

‘Loving Our Environment’ series for classes 3 to 5 has been written in compliance with the latest syllabus as presented by the NCERT. The series is learner-friendly and has been designed with an objective to create social awareness in the students, in a stimulating and enjoyable manner. The lessons have been presented in a simple and explicit language to facilitate comprehension. At the end of each lesson a brief summary has been provided for an easy recap. The exercises evoke and build on their logical thinking and analytical skills. They also foster in the learners an initiative to do activities and projects, provided at the end of the lesson.

Skin, the largest organ of the human body, makes up the main barrier to prevent the invasion of pathogenic organisms and the loss of water. Any injuries to the skin caused by trauma, diseases, or aging will lead to skin dysfunctions, resulting in a series of physical and mental disorders. Wound healing is a complex and fragile process, accompanied by hemostasis, inflammation, proliferation, and remodeling. Any abnormality in each process may lead to delayed wound healing and/or conspicuous scars. In addition, direct contact with the outside environment and stimulation by various external factors, such as ultraviolet radiation, microorganisms, etc., will cause a series of inflammatory reactions, leading to skin cell aging, affecting stem cell activity and wound healing. Therefore, it is necessary to have a deep understanding of the mechanisms of skin injuries and to explore effective prevention and therapeutic strategies to facilitate the process of skin repair.

CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which includes Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells. Like iNKT cells, MR1-restricted T cells express semi-invariant TCRs and display innate-like functions. MR1-restricted T cells, also called mucosal-associated invariant T (MAIT) cells, have been implicated in immune responses against a variety of pathogens such as Mycobacterium tuberculosis, Pseudomonas aeruginosa, Helicobacter pylori, hepatitis C virus and influenza virus. Moreover, these cells contribute to autoimmune and inflammatory diseases, including colitis, rheumatoid arthritis, psoriasis, lupus, and diabetes.