The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.

The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.

The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.

The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.

This book combines the advantages of high-dimensional data visualization and machine learning in the context of identifying complex n-D data patterns. It vastly expands the class of reversible lossless 2-D and 3-D visualization methods, which preserve the n-D information. This class of visual representations, called the General Lines Coordinates (GLCs), is accompanied by a set of algorithms for n-D data classification, clustering, dimension reduction, and Pareto optimization. The mathematical and theoretical analyses and methodology of GLC are included, and the usefulness of this new approach is demonstrated in multiple case studies. These include the Challenger disaster, world hunger data, health monitoring, image processing, text classification, market forecasts for a currency exchange rate, computer-aided medical diagnostics, and others. As such, the book offers a unique resource for students, researchers, and practitioners in the emerging field of Data Science.

Recent advances in immunology and molecular biology have resulted in new therapeutic approaches being generated and implemented in cancer clinics. The discovery of new antigens, mechanisms of antigen presentation, and interplay of cells involved in anti-tumor immunity have made the clinical control of some cancers more plausible than previously tho

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. - Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside - Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios - Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications

Skin, the largest organ of the human body, makes up the main barrier to prevent the invasion of pathogenic organisms and the loss of water. Any injuries to the skin caused by trauma, diseases, or aging will lead to skin dysfunctions, resulting in a series of physical and mental disorders. Wound healing is a complex and fragile process, accompanied by hemostasis, inflammation, proliferation, and remodeling. Any abnormality in each process may lead to delayed wound healing and/or conspicuous scars. In addition, direct contact with the outside environment and stimulation by various external factors, such as ultraviolet radiation, microorganisms, etc., will cause a series of inflammatory reactions, leading to skin cell aging, affecting stem cell activity and wound healing. Therefore, it is necessary to have a deep understanding of the mechanisms of skin injuries and to explore effective prevention and therapeutic strategies to facilitate the process of skin repair.

Knapp und präzise erklärt dieses einführende Lehrbuch der Immunologie die Funktion des Immunsystems anhand sorgfältig ausgewählter Beispiele aus der klinischen Praxis und dem Experiment. Von Büchern mit ähnlichem Themenspektrum unterscheidet es sich durch den klar evidenzbasierten Ansatz. Die Autoren -- ein erfahrener Dozent und ein angesehener Forscher -- regen dabei stets zur kritischen Reflexion des gelernten Stoffs an. Based on examples using clinical and experimental data, this concise introductory textbook provides an insight into the immune system, prompting readers to ask critical questions in order to further advance our understanding. Website: www.wiley-vch.de/home/immunology

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.