Adult or postnatal stem cells offer life-long cell replacement in tissues and organs, and are thus unavoidable targets of long-term and transient regenerative/epigenetic gene therapy for both inherited and acquired diseases; and effective anticancer therapy. In particular, autologous stem cells have been instrumental to the success of gene therapy, enabling breakthrough endonuclease-boosted gene targeting for gene correction (inherited diseases) or targeted integration of therapeutic transgenes (other disorders).This timely book highlights the pioneering translation of adult pluripotent stem cells as a substitute for tissue-specific stem cells, thereby pinpointing the invaluable potential for stem cell gene therapy applications of autologous cells to contribute to all three germ players. Pathologies are discussed in terms of stem cell repopulation dynamics, with appropriate niches (long-term engraftment) and tissues (cell turnover). Focus is also placed on the increasing number of identified tissue-specific cancer stem cells as the ultimate targets for recurrence-free cancer recovery, and on the development of armed stem cells as tumor-homing vectors for targeted anticancer stem cell gene therapy.

Geosciences particularly numerical weather predication, are demanding the highest levels of computer power available. The European Centre for Medium-Range Weather Forecasts, with its experience in using supercomputers in this field, organizes a workshop every other year bringing together manufacturers, computer scientists, researchers and operational users to share their experiences and to learn about the latest developments. This volume provides an excellent overview of the latest achievements and plans for the use of new parallel techniques in the fields of meteorology, climatology and oceanography.

Geosciences and, in particular, numerical weather prediction are demanding the highest levels of available computer power. The European Centre for Medium-Range Weather Forecasts, with its experience in using supercomputers in this field, organizes every other year a workshop bringing together manufacturers, computer scientists, researchers and operational users to share their experiences and to learn about the latest developments. This volume provides an excellent overview of the latest achievements and plans for the use of new parallel techniques in the fields of meteorology, climatology and oceanography.

This book constitutes the thoroughly refereed post-conference proceedings of the 8th International Conference on High Performance Computing for Computational Science, VECPAR 2008, held in Toulouse, France, in June 2008. The 51 revised full papers presented together with the abstract of a surveying and look-ahead talk were carefully reviewed and selected from 73 submissions. The papers are organized in topical sections on parallel and distributed computing, cluster and grid computing, problem solving environment and data centric, numerical methods, linear algebra, computing in geosciences and biosciences, imaging and graphics, computing for aerospace and engineering, and high-performance data management in grid environments.

This book, presented in three volumes, examines environmental disciplines in relation to major players in contemporary science: Big Data, artificial intelligence and cloud computing. Today, there is a real sense of urgency regarding the evolution of computer technology, the ever-increasing volume of data, threats to our climate and the sustainable development of our planet. As such, we need to reduce technology just as much as we need to bridge the global socio-economic gap between the North and South; between universal free access to data (open data) and free software (open source). In this book, we pay particular attention to certain environmental subjects, in order to enrich our understanding of cloud computing. These subjects are: erosion; urban air pollution and atmospheric pollution in Southeast Asia; melting permafrost (causing the accelerated release of soil organic carbon in the atmosphere); alert systems of environmental hazards (such as forest fires, prospective modeling of socio-spatial practices and land use); and web fountains of geographical data. Finally, this book asks the question: in order to find a pattern in the data, how do we move from a traditional computing model-based world to pure mathematical research? After thorough examination of this topic, we conclude that this goal is both transdisciplinary and achievable.

This book constitutes the thoroughly refereed post-conference proceedings of the 23rd International Symposium on High Performance Computing Systems and Applications, HPCS 2009, held in Kingston, Canada, in June 2009. The 29 revised full papers presented - fully revised to incorporate reviewers' comments and discussions at the symposium - were carefully selected for inclusion in the book. The papers are organized in topical sections on turbulence, materials and life sciences, bringing HPC to industry, computing science, mathematics, and statistics, as well as HPC systems and methods.

Every day we need to solve large problems for which supercomputers are needed. High performance computing (HPC) is a paradigm that allows to efficiently implement large-scale computational tasks on powerful supercomputers unthinkable without optimization. We try to minimize our effort and to maximize the achieved profit. Many challenging real world problems arising in engineering, economics, medicine and other areas can be formulated as large-scale computational tasks. The volume is a comprehensive collection of extended contributions from the High performance computing conference held in Borovets, Bulgaria, September 2019. This book presents recent advances in high performance computing. The topics of interest included into this volume are: HP software tools, Parallel Algorithms and Scalability, HPC in Big Data analytics, Modelling, Simulation & Optimization in a Data Rich Environment, Advanced numerical methods for HPC, Hybrid parallel or distributed algorithms. The volume is focused on important large-scale applications like Environmental and Climate Modeling, Computational Chemistry and Heuristic Algorithms.

High Performance Computing: Programming and Applications presents techniques that address new performance issues in the programming of high performance computing (HPC) applications. Omitting tedious details, the book discusses hardware architecture concepts and programming techniques that are the most pertinent to application developers for achievi

Cloud Computing in Ocean and Atmospheric Sciences provides the latest information on this relatively new platform for scientific computing, which has great possibilities and challenges, including pricing and deployments costs and applications that are often presented as primarily business oriented. In addition, scientific users may be very familiar with these types of models and applications, but relatively unfamiliar with the intricacies of the hardware platforms they use. The book provides a range of practical examples of cloud applications that are written to be accessible to practitioners, researchers, and students in affiliated fields. By providing general information on the use of the cloud for oceanographic and atmospheric computing, as well as examples of specific applications, this book encourages and educates potential users of the cloud. The chapters provide an introduction to the practical aspects of deploying in the cloud, also providing examples of workflows and techniques that can be reused in new projects. - Provides real examples that help new users quickly understand the cloud and provide guidance for new projects - Presents proof of the usability of the techniques and a clear path to adoption of the techniques by other researchers - Includes real research and development examples - that are ideal for cloud computing adopters in ocean and atmospheric domains

Collects in four chapters single monographs related to the fundamental advances in parallel computer systems and their developments from different points of view (from computer scientists, computer manufacturers, end users) and related to the establishment and evolution of grids fundamentals, implementation and deployment.