Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.

TABLE OF CONTENTS PREFACE INTRODUCTION THE ARMENIANS UNDER TURKISH DOMINATION: FROM THE EARLY TIMES ONWARDS a) The Establishment of the Armenian Pati'iarchate b) The Armenian Populatian Figures in the 16th Century in Anatolia CHAPTER I A GENERAL LOOK AT THE ARMENIAN QUESTION RIGHT UP TO THE OUTBREAK OF THE FIRST WORLD WAR A) European Powers' and Russia's Policies in the Near East a) The Incitement of the Armenians b) The Armenians' Demands c) Armenian Reforms d) The Forming of the Armenian Organisations e) First Acts of Violence Committed by the Armenian Revolutionary Organisations f) The Prince Sabahattin Mavement and the Armenians. g) The Adana Violence and the Efforts to establish an independent Armenia B) The Armenians During The Course Of The First World War a) Cooperation of the Armenians with the Russians b) The Van Uprising C) ATROCITIES COMMITIED BY THE ARMENIANS AND THE COUNTER-MEASURES a) The Transfer of the Zeytun Armenians to Konya b) The Closing Down of the Armenian Associations CHAPTER II A) The Making of the Decision for the Relocation of the Armenians and its Implementation a) The Purpose of the Relocation b) The Transfer of the Armenians to New Places for Resenlement c) Attacks on the Armenian Convoys and the Counter Measures taken by the State d) The Armenians not subjected to Relocation and Armenians who converted to Islam to escape it e) Provisions for the relocated Armenians O The Property of the Relocated Armenians g) The Relocation of the Armenians and its Reflections Abroad and the Documented Relocation h) The Armenians af ter the Completion of the Relocation B) The Situation after the Relocation and the Decree of Return CONCLUSION INDEX BIBllOG RAPHY ANNEX.

This book aims to contain in one convenient reference source much of the information needed to manage patients with abnormal blood lipids and lipoproteins. It draws heavily on ATP III and shows how these new guidelines can be incorporated into clinical practice.