This book provides a serious introduction to the subject of mass spectrometry, providing the reader with the tools and information to be well prepared to perform such demanding work in a real-life laboratory. This essential tool bridges several subjects and many disciplines including pharmaceutical, environmental and biomedical analysis that are utilizing mass spectrometry: Covers all aspects of the use of mass spectrometry for quantitation purposes Written in textbook style to facilitate understanding of this topic Presents fundamentals and real-world examples in a ‘learning-though-doing’ style

Trace Analysis is a highly practical book which deals with the science rather than the paperwork of quality assurance systems. Produced as part of the UK Valid Analytical Measurement (VAM) initiative, it provides the analyst with a systematic approach across the broad spectrum of trace analysis, offering practical advice and guidance on methodology and techniques. The book is structured to take the analyst step-by-step through the stages of any trace analysis. The approach is general, being broken down only into types of analyte. Additional chapters explain the application of groups of techniques to each analyte type. Each section contains references to published material which will allow the analyst to obtain further information on specific topics. Throughout the book, the analyst is reminded of pitfalls which lead to unreliable results. This new book therefore offers invaluable advice to analysts in all areas and at all levels, providing practical 'expert' advice on methodology. It will prove indispensable as a single, comprehensive bench guide for analysts in university, college and industrial laboratories.

Trace Analysis by Mass Spectrometry deals with trace analysis of solids and liquids by mass spectrometric techniques. Topics include the physics and techniques of electrical discharge ion sources, transmission of ions through double focusing mass spectrometers, and detection and measurement of ions by ion-sensitive plates. The ion sources used are principally electrical discharge type sources. This book is comprised of 14 chapters. The first several chapters focus on the basic physics of electrical discharge ion sources, double focusing mass spectrometry, and the measurement of arrays of mass resolved ion beams by electrical detection methods and with ion sensitive emulsions. The discussion then shifts to the problem of obtaining the chemical composition of the recorded mass resolved ion sample and relating this composition to that of the original sample. The chapters that follow describe specific techniques for analyzing special samples such as insulators, powders, microsamples, biological materials, reactive and low melting point substances, radioactive materials, and gases in solids. The remaining chapters include the use of laser ion sources in the analysis of solids and the analysis of surfaces particularly with sputter ion sources. This book will be of interest to students and practitioners of physics and chemistry.

This handbook is unique in its comprehensive coverage of the subject and focus on practical applications in diverse fields. It includes methods for sample preparation, the role of certified reference materials, calibration methods and statistical evaluation of the results. Problems concerning inorganic and bioinorganic speciation analysis, as well as special aspects such as trace analysis of noble metals, radionuclides and volatile organic compounds are also discussed. A significant part of the content presents applications of methods and procedures in medicine (metabolomics and therapeutic drug monitoring); pharmacy (the analysis of contaminants in drugs); studies of environmental samples; food samples and forensic analytics – essential examples that will also facilitate problem solving in related areas.

"Organic Trace Analysis" presents the basics of trace analysis, from sample preparation to the measurement: Students are introduced to statistical evaluation, quality control technologies, sampling and preparation of organic traces, as well as to enrichment and separation of samples. Spectroscopic techniques as chromatography, capillary electrophoresis, mass spectrometry, and receptor-based bioanalysis are presented in detail.

The trace determination of pesticides continues to be a topic for analytical chemists working in research centres, government and universities. With four chapters devoted to chromatography-mass spectrometry methods, readers are able to understand the analytical basis, technical characteristics and possibilities to evaluate pesticides in food by gas chromatography (GC) and liquid chromatography (LC) mass spectrometry. The book also provides a well-defined and critical compilation of the sample treatment and clean-up procedures, as well as injection techniques applied in GC and LC food analysis. Finally the book deals with aspects related to analytical quality control requirements for pesticide residues, in addition to pesticide regulation aspects.* Contains specific chapters devoted to chromatography-mass spectrometry methods* Provides a well-defined and critical compilation of the sample treatment and clean-up procedures* Contains aspects related to analytical quality control requirements for pesticide residues

This title brings forensic scientists and chemists up-to-date on the latest instrumental methods for analysing trace evidence, including mass spectrometry, image analysis, DIOS-MS, ELISA characterization, statistical validation, and others. Illustrates comparative analysis of trace evidence by both old and new methods. Explains why some newer methods are superior to older, established methods. Includes chapters on analysis of DNA, ink, dyes, glitter, gun powder traces, condom trace evidence, footwear impressions, toolmark impressions, surveillance videos, glass particles, and dirt. Discusses applications such as mass spectrometry, image analysis, desorption-ionization on silicon mass spectrometry (DIOS-MS), ELISA characterization, and statistical validation.

Spurenanalyse von den theoretischen Grundlagen über die apparative Ausrüstung bis zur Probenpräparation - dieses Buch bringt Ihr Wissen über ICP-MS, HPLC-AAS, HPLC-ICP-MS und konventionellere Methoden auf den aktuellsten Stand. Viele Illustrationen und Beispiele aus der Praxis - so der biologischen Analytik und der Analytik hochreiner Materialien - empfehlen das Buch besonders für fortgeschrittene Studenten und Graduierte.

It also includes information on processing and interpreting results to obtain high-quality data.".

Trace element analysis has a key role to play in quality control of food and diet. This timely book introduces the subject in a practical way - from sampling and the techniques available for trace analysis, to procedures for specific elements and data analysis. Beginning with a brief introduction and discussion of statistical evaluation of data, the subsequent chapter looks at trace analysis in general, with its essentials and terminology. Another section introduces sampling and preparation of foodstuffs such as wheat, potato, vegetables and milk. This is followed by descriptions of the various spectrometric techniques (atomic absorption, atomic emission, atomic fluorescence) that are available. Plasma techniques for both optical emission and mass spectrometry are presented, as are nuclear activation analysis and X-ray methods. A comparison of the various analytical techniques is provided, and a separate chapter handles speciation analysis. Finally, procedures for determining essential and toxic elements such as arsenic, iron, selenium and zinc are suggested, using several recent references. Detailed explanations and a simple format will appeal to laboratory technicians and graduate students, as well as more experienced researchers. Comprehensive coverage, coupled with illustrations and a guide to relevant literature and manufacturers, will make Trace Element Analysis of Food and Diet a valuable source of information for anyone working on analysis of trace elements in food, diet or other biological or environmental samples - particularly food engineers, agricultural scientists and government testing agency employees.