Interactivity is the catchword for a wide range of innovative solutions that concept designers and engineers are developing in every area of technology and culture. For the authors interaction is more than a technological or aesthetic concept, it is a new means to ally humans and technology in a dynamic and reciprocal form of “living in technology”. This publication gathers together scientists and contributors from diverse fields of activity, providing a fascinating, up-to-date survey of the technological and conceptual equipment of experts engaged in aesthetic disciplines and product design. The editor, Professor Gerhard M. Buurman, is Head of Interactiondesign at the University of Art, Media and Design (HGKZ) in Zurich.

This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein–protein interactions (PPIs) of proteasome assembling chaperone (PAC) 3 homodimer, and elucidates the mechanism by nuclear magnetic resonance (NMR) studies. Interfaces of PPIs recently have been expected to be novel therapeutic targets, while it is difficult to apply conventional methodology based on lock and key theory. The author achieved the first total synthesis of TB1 and its spin-labeled derivative to carry out NMR experiments because the supply of TB1 from natural sources was limited. Unique 2,2’,6,6’-tetrasubstituted diphenyl ether moiety of TB1 was synthesized from a depsidone skeleton by chemoselective reduction of lactone. In the process of elongating side wings, efficient formylation utilizing dichloromethyl methyl ether–silver trifluoromethanesulfonate was developed for the sterically hindered aromatic compound. NMR titration experiments and paramagnetic relaxation enhancement observation of PAC3 homodimer were performed with synthesized TB1 and its molecular probe, respectively. The results of the above NMR studies and additional in silico docking studies suggested that TB1 promotes the dissociation to monomeric PAC3 after interaction with PAC3 homodimer. The rare mechanism shown in this book indicates a potential novel drug target in the interfaces of PPIs with no cavity or groove.

The world we live in exhibits, on different scales, many phenomena related to the diffusion of gases. Among them are the movement of gases in earth strata, the aeration of soils, the drying of certain materials, some catalytic reactions, purification by adsorption, isotope separation, column chro matography, cooling of nuclear reactors, and the permeability of various packing materials. The evolution of the understanding of this subject has not always been straightforward and progressive-there has been much confusion and many doubts and misunderstandings, some of which remain to this day. The main reason for the difficulties in the development of this subject is, we now know, the lack of an understanding of the effects of walls on diffusing systems. Textbooks usually treat diffusion on two levels: at the physicochemi cal or molecular level, making use of the kinetic theory of gases (which while a very rigorous and well-founded theory nevertheless is valid only for systems without walls), or at the level of a transport phenomenon, a level geared toward applications. The influence of walls is usually disregarded or is treated very briefly (for example, by taking account of the Knudsen regime or by introducing a transition regime of limited validity) in a way unconnected with previous studies. As a consequence, the extensive, gener alized, and well-founded knowledge of systems without walls has often been applied without sound basis to real situations, i.e., to systems with walls.

This book was originally published in 1990 and was the first text to consider the definitive fundamental science of landfill biotechnology. Since then, major research initiatives, particularly in the U.K. and South Africa, have resulted in considerable advancement in our knowledge of landfill microbiology. The Second Edition details this progress. Text considers the latest findings in landfill leachate treatment, co-disposal and fundamental microbiology. It brings together the expertise of the immediate complementary, but often disparate disciplines of soil science, environmental engineering, applied mathematics, and land reclamation and focuses on the common goal of the scientific design and management of landfill sites. The book also includes effective laboratory models and selected approaches.

The fourth volume of the Collected Works is devoted to Wigners contribution to physical chemistry, statistical mechanics and solid-state physics. One corner stone was his introduction of what is now called the Wigner function, while his paper on adiabatic perturbations foreshadowed later work on Berry phases. Although few in number, Wigners articles on solid-state physics laid the foundations for the modern theory of the electronic structure of metals.

Nuclear structure Physics connects to some of our fundamental questions about the creation of universe and its basic constituents. At the same time, precise knowledge on the subject has lead to develop many important tools of human kind such as proton therapy, radioactive dating etc. This book contains chapters on some of the crucial and trending research topics in nuclear structure, including the nuclei lying on the extremes of spin, isospin and mass. A better theoretical understanding of these topics is important beyond the confines of the nuclear structure community. Additionally, the book will showcase the applicability and success of the different nuclear effective interaction parameters near the drip line, where hints for level reordering have already been seen, and where one can test the isospin-dependence of the interaction. The book offers comprehensive coverage of the most essential topics, including: • Nuclear Structure of Nuclei at or Near Drip-Lines • Synthesis challenges and properties of Superheavy nuclei • Nuclear Structure and Nuclear models - Ab-initio calculations, cluster models, Shell-model/DSM, RMF, Skyrme • Shell Closure, Magicity and other novel features of nuclei at extremes • Structure of Toroidal, Bubble Nuclei, halo and other exotic nuclei These topics are not only very interesting from theoretical nuclear physics perspective but are also quite complimentary for ongoing nuclear physics experimental program worldwide. It is hoped that the book chapters written by experienced and well known researchers/experts will be helpful for the master students, graduate students and researchers and serve as a standard & uptodate research reference book on the topics covered.

There are a number of people I wish to acknowledge for helping me write this book. First, the idea of politics as a nonequilibrium process owes its origins largely to a series of ongoing conservations I have had with Father Richard Telnack, o. c. s. o. Our discussions of Augustine's city of God and Hegel's Phenomenology in the hours before the night office led me to think about the world more as an ongoing flux than as a static rational order. The use of structurally unstable dynamical systems to. model democratic politics was greatly enhanced by my interactions with Professor Alex Kleiner, department of mathematics, Drake University. Professor Manfred Holler of the University of Aarhus provided a detailed critique of an earlier version. His insights and remarks were invaluable in improving the work's content and structure. I also wish to thank Dr. Werner A. Muller, director of Physica Verlag for his confidence in my work and his efforts on my behalf. Miss Jane Blevins was a patient and thorough typist. I thank her for her attention to the production of the manuscript. Finally, writing a book is in one way a moral act. It requires committment to pursue a line of thought to its conclusion when the final results are not clear. without the encouragement and support of my wife over a long period of time, I would have certainly faltered. Whatever good emerges from the work is due largely to her example and patient endurance.

The most authoritative and comprehensive book available on dreams and dreaming. Enter the fascinating world of dreams, their mysteries, their meanings: to dream of a bird flying freely represents hopes and aspirations; to dream of winter means a time in life that is not fruitful; to be visited by someone in a dream can mean that there is information, warmth, or love available; to be searching in a dream is an attempt to find an answer to a problem. These are just a few of the 10,000 dream images and interpretations contained in this volume, a book that can bring insight, clarification, and guidance.