The fourth edition of the TNM Classification was published in 1987,1 and a revision in 1992.2 It was the result of efforts by all national TNM Committees towards a worldwide uniform classification. The classifica tion criteria are identical with the fourth edition of the Manual for 3 Staging of Cancer of the American Joint Committee on Cancer (AJCC). Although the classification has found wide acceptance, some workers have pointed out that individual definitions and rules for staging are not sufficiently detailed. This can lead to inconsistent application of the clas sification. the antithesis of standardization. This source of differences in interpretation applies not only to the classification of individual organs but also to the general rules of the system, especially to the definitions of the requirements for the pathological classification (pT, pN). These are specified only for carcinoma of the breast; for other sites, reference must be made back to the general rules. which can lead to variable interpreta tions. The TNM Project Committee of the UICC has addressed this prob lem and collected and considered the criticisms and suggestions from the national TNM Committees as well as from cancer registries, oncolo gical associations and individual users. The result was the decision to complement the 4th edition of the TN M Classification 1.2. 3 with the publi cation of a TNM Supplement containing recommendations for the uni form use of TNM.

The Second Edition of TNM Staging Atlas with Oncoanatomy has been updated to include all new cancer staging information from the Seventh Edition of the AJCC Cancer Staging Manual. The atlas presents cancer staging in a highly visual rapid-reference format, with clear full-color diagrams and TNM stages by organ site. The illustrations are three-dimensional, three-planar cross-sectional presentations of primary anatomy and regional nodal anatomy. They show the anatomic features identifiable on physical and/or radiologic examination and the anatomic extent of cancer spread which is the basis for staging. A color code indicates the spectrum of cancer progression at primary sites (T) and lymph node regions (N). The text then rapidly reviews metastatic spread patterns and their incidence. For this edition, CT or MRI images have been added to all site-specific chapters to further detail cancer spread and help plan treatment. Staging charts have been updated to reflect changes in AJCC guidelines, and survival curves from AJCC have been added.

This book, containing the proceedings of the 2000 Kyoto Symposium on Esophageal Cancer, is an important contribution for all types of physicians interested in both squamous and adenocarcinoma of the esophagus. The volume has great legitimacy and relevance. The symposia hosted by Professor Masayuki Imamura brought together the leaders in several disciplines from Japan with other acknowledged authorities from Europe, the United States, Australia, and other parts of Asia. Japan has long been a leader in making advances in understanding the pathology, diagnosis, and treatment of esophageal squamous cell carcinoma, for several decades originally led by Professor Komei Nakayama and his students. It is now clear that Japanese are also beginning to suffer from esophageal adenocarcinoma and Barrett's columnar lined epithelium, thus enabling the Japanese to formulate studies on the pathology, diagnosis, and treatment for the full spectrum of esophageal neoplasms. The authoritativeness of these proceedings is established not only by the long tradi tion of Japanese leadership in the field but by the contributions of the principal leaders from the Nakayama school participating in the honorary faculty and local scientific committee.

TNM Classification of Malignant Tumours Sixth Edition The TNM system is the most widely used means for classifying the extent of cancer spread. TNM Classification of Malignant Tumours, Sixth Edition provides the new, internationally agreed-upon standards to describe and categorize cancer stages and progression. Published in affiliation with the International Union Against Cancer (UICC), this pocket guide contains important new and updated organ-specific classifications that oncologists and other professionals who treat patients with cancer must use (starting with cases diagnosed and treated in 2003) to adequately classify tumours for prognosis and treatment. Revised standards include: * Major alterations in the classifications concerning carcinomas of the liver, biliary tract and pancreas, pleural mesothelioma, bone tumours, malignant melanoma of the skin, ophthalmic tumours, and the regional lymph node classification of breast carcinoma * A nasal cavity tumour classification * Changes in classification of head and neck tumours * Risk factors for gestational trophoblastic tumours have been modified according to FIGO recommendations * New subcategories in gastric, prostate, and kidney tumour classifications and in the stage grouping of colorectal carcinoma * Schemes for recording the assessment of sentinel lymph nodes and isolated tumour cells * The definition of the y symbol for cases classified during or after initial multimodality therapy has been further clarified These changes will enhance the value of TNM in treatment planning and as a prognostic indicator.

Filling the need for a comprehensive, fully-illustrated guide to the subject, this practical manual demonstrates a logical approach to the preparation, dissection, and handling of the tissue specimens most commonly encountered in today's surgical pathology laboratory. Each dissection is vividly illustrated with powerful 3D line drawings created exclusively for this book. The authors discuss the clinically important features of various types of specimens and lesions over the whole range of organ systems. The consistent approach provides a valuable conceptual framework for points to bear in mind during the dissection and each chapter concludes with a convenient reminder of the important issues to address in the surgical pathology report. Indispensable for staff pathologists, residents, pathologist's assistants, histotechnologists and other laboratory personnel.

The practical application of the sentinel node concept is evaluated in this book. The concept is analyzed for breast cancer, malignant melanoma, tumors of the face, oropharynx, lung, gastrointestinal and urogenital tract. The first part of the book describes the function and use of the nuclear medicine equipment, the tracers used, colloid solutions and modern developments in histological and immunohistochemical lymph node investigations, as well as possible pitfalls. In the second part, specific tumor-related problems are described.

Analytical Morphology is a new discipline dealing with the analysis of cell and tissue components using analytical maneuvers that go beyond those of conventional morphology and histopathology. It utilizes new advances in other disciplines, such as immunology, molecular biology, laser technology, microwave technology and computer science, to highlight cellular components such as peptides, proteins, or nucleotide sequences through chemical, physical, immunological, or molecular biological reactions. These methods include immunocytochemistry, in situ hybridization, in situ PCR, antigen retrieval, image analysis, and the like. The book is intended for morphological scientists, pathologists, advanced students, and technicians who are interested in keeping abreast of this rapidly emerging discipline.

TNM Classification of Malignant Tumours, 7th Edition provides the latest, internationally agreed-upon standards to describe and categorize cancer stages and progression. Published in affiliation with the International Union Against Cancer (UICC), this authoritative guide contains important updated organ-specific classifications that oncologists and other professionals who manage patients with cancer need to accurately classify tumours for staging, prognosis and treatment. The major alterations addressed in the 7th Edition concern carcinomas of the oesophagus and the gastroesophageal junction, stomach, lung, appendix, biliary tract, skin, and prostate. In addition, there are several entirely new classifications: gastrointestinal carcinoids (neuroendocrine tumours) gastrointestinal stromal tumour upper aerodigestive mucosal melanoma Merkel cell carcinoma uterine sarcomas intrahepatic cholangiocarcinoma adrenal cortical carcinoma. A new approach has also been adopted to separate anatomical stage groupings from prognostic groupings in which other prognostic factors are added to T, N, and M categories. These new prognostic groupings, as well as the traditional anatomical groupings, are presented for oesophageal and prostate carcinomas. Visit www.wileyanduicc.com for more information about the International Journal of Cancer and our other UICC book titles

The Union for International Cancer Controls (UICC) TNM classification system is the most widely used cancer classification and staging system in the world. It is used to describe the anatomical extent of disease and it is essential to patient care, research and cancer control. This fifth edition of the TNM Supplement: A Commentary of Uniform Use offers practitioners a wealth of material intended to complement the systems day-to-day use. The volume features: Updated definitions of terms used in cancer staging. New sections on carcinomas of the thymus, sarcomas of the spine and pelvis and soft tissue sarcomas of the head and neck, and comprehensive updates to the head and neck carcinomas, carcinomas of the lung and neuroendocrine tumours sections. Frequently asked questions from the UICC helpdesk. The Supplement may be treated as a companion text to the recent eighth edition of the TNM Classification of Malignant Tumours (978-1-119-26357-9), supporting the correct and uniform application of the TNM classification system. The TNM Supplement can also be utilised as a standalone book, providing explanations and examples to answer many questions that arise during the daily use of the TNM cancer classification and staging system, particularly in unusual cases.

Conformal radiation therapy represents a new challenge. It offers the prospect of either increasing the radiation dose to target tissues while delivering a similar dose to organs at risk, or reducing the dose to organs at risk while maintaining the dose to target tissues. First, lymph node areas at risk are established using the available data from pathological examination. Then, based on a three-dimensional description of the anatomical regions, guidelines for the delineation of the clinical target volumes are proposed. The data presented should enable the reader to make appropriate decisions regarding the selection and delineation of the target volumes when confronted with the most frequent tumor types and sites.