Renowned scholars in history, sociology, philosophy and anthropology consider seventeenth and twentieth century weapon testing, particle physics, biology and other topics in an account of important and often famous experiments.

Scientific experimentation with humans has a long history. Combining elements of history of science with history of medicine, The Uses of Humans in Experiment illustrates how humans have grappled with issues of consent, and how scientists have balanced experience with empiricism to achieve insights for scientific as well as clinical progress. The modern incarnation of ethics has often been considered a product of the second half of the twentieth century, as enshrined in international laws and codes, but these authors remind us that this territory has long been debated, considered, and revisited as a fundamental part of the scientific enterprise that privileges humans as ideal subjects for advancing research.

Laboratory Experiments in the Social Sciences is the only book providing core information for researchers about the ways and means to conduct experiments. Its comprehensive regard for laboratory experiments encompasses "how-to explanations, investigations of philosophies and ethics, explorations of experiments in specific social science disciplines, and summaries of both the history and future of social science laboratories. No other book offers such a direct avenue to enlarging our knowledge in the social sciences.This collection of original chapters combines instructions and advice about the design of laboratory experiments in the social sciences with the array of other issues. While there are books on experimental design and chapters in more general methods books on design, theory, and ethical issues, no other book attempts to discuss the fundamental ideas of the philosophy of science or lays out the methods comprehensively or in such detail. Experimentation has recently prospered because of increasing interest in cross-disciplinary syntheses, and this book of advice, guidelines, and observations underline its potential and increasing importance.· Provides a comprehensive summary of issues in social science experimentation, from ethics to design, management, and financing· Offers "how-to" explanations of the problems and challenges faced by everyone involved in social science experiments· Pays attention to both practical problems and to theoretical and philosophical arguments· Defines commonalities and distinctions within and among experimental situations across the social sciences

Experiments are a central methodology in the social sciences. Scholars from every discipline regularly turn to experiments. Practitioners rely on experimental evidence in evaluating social programs, policies, and institutions. This book is about how to “think” about experiments. It argues that designing a good experiment is a slow moving process (given the host of considerations) which is counter to the current fast moving temptations available in the social sciences. The book includes discussion of the place of experiments in the social science process, the assumptions underlying different types of experiments, the validity of experiments, the application of different designs, how to arrive at experimental questions, the role of replications in experimental research, and the steps involved in designing and conducting “good” experiments. The goal is to ensure social science research remains driven by important substantive questions and fully exploits the potential of experiments in a thoughtful manner.

What role have experiments played, and should they play, in physics? How does one come to believe rationally in experimental results? The Neglect of Experiment attempts to provide answers to both of these questions. Professor Franklin's approach combines the detailed study of four episodes in the history of twentieth century physics with an examination of some of the philosophical issues involved. The episodes are the discovery of parity nonconservation ( or the violation of mirror symmetry) in the 1950s; the nondiscovery of parity nonconservation in the 1930s, when the results of experiments indicated, at least in retrospect, the symmetry violation, but the significance of those results was not realized; the discovery and acceptance of CP ( combined parity-charge conjugations, paricle-antiparticle) symmetry; and Millikan's oil-drop experiment. Franklin examines the various roles that experiment plays, including its role in deciding between competing theories, confirming theories, and calling fo new theories. The author argues that one can provide a philosophical justification for these roles. He contends that if experiment plays such important roles, then one must have good reason to believe in experimental results. He then deals with deveral problems concerning such reslults, including the epistemology of experiment, how one comes to believe rationally in experimental results, the question of the influence of theoretical presuppositions on results, and the problem of scientific fruad. This original and important contribution to the study of the philosophy of experimental science is an outgrowth of many years of research. Franklin brings to this work more than a decade of experience as an experimental high-energy physicist, along with his significant contributions to the history and philosophy of science.

In recent years, social scientists have engaged in a deep debate over the methods appropriate to their research. Their long reliance on passive observational collection of information has been challenged by proponents of experimental methods designed to precisely infer causal effects through active intervention in the social world. Some scholars claim that field experiments represent a new gold standard and the best way forward, while others insist that these methods carry inherent inconsistencies, limitations, or ethical dilemmas that observational approaches do not. This unique collection of essays by the most influential figures on every side of this debate reveals its most important stakes and will provide useful guidance to students and scholars in many disciplines.

. . . the topic of 'meaning' is the one topic discussed in philosophy in which there is literally nothing but 'theory' - literally nothing that can be labelled or even ridiculed as the 'common sense view'. Putnam, 'The Meaning of Meaning' This book explores some truths behind the truism that experimentation is a hallmark of scientific activity. Scientists' descriptions of nature result from two sorts of encounter: they interact with each other and with nature. Philosophy of science has, by and large, failed to give an account of either sort of interaction. Philosophers typically imagine that scientists observe, theorize and experiment in order to produce general knowledge of natural laws, knowledge which can be applied to generate new theories and technologies. This view bifurcates the scientist's world into an empirical world of pre-articulate experience and know how and another world of talk, thought and argument. Most received philosophies of science focus so exclusively on the literary world of representations that they cannot begin to address the philosophical problems arising from the interaction of these worlds: empirical access as a source of knowledge, meaning and reference, and of course, realism. This has placed the epistemological burden entirely on the predictive role of experiment because, it is argued, testing predictions is all that could show that scientists' theorizing is constrained by nature. Here a purely literary approach contributes to its own demise. The epistemological significance of experiment turns out to be a theoretical matter: cruciality depends on argument, not experiment.

The effective design of scientific experiments is critical to success, yet graduate students receive very little formal training in how to do it. Based on a well-received course taught by the author, Experimental Design for Biologistsfills this gap. Experimental Design for Biologistsexplains how to establish the framework for an experimental project, how to set up a system, design experiments within that system, and how to determine and use the correct set of controls. Separate chapters are devoted to negative controls, positive controls, and other categories of controls that are perhaps less recognized, such as “assumption controls†and “experimentalist controls†. Furthermore, there are sections on establishing the experimental system, which include performing critical “system controls†. Should all experimental plans be hypothesis-driven? Is a question/answer approach more appropriate? What was the hypothesis behind the Human Genome Project? What color is the sky? How does one get to Carnegie Hall? The answers to these kinds of questions can be found in Experimental Design for Biologists. Written in an engaging manner, the book provides compelling lessons in framing an experimental question, establishing a validated system to answer the question, and deriving verifiable models from experimental data. Experimental Design for Biologistsis an essential source of theory and practical guidance in designing a research plan.

Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.

Explores the development of natural history since the Renaissance and contextualizes current discussions of biodiversity.