The Synthesis And Evaluation Of Novel Bioreductive Anticancer Agents
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Author |
: Pilar Munoz Ruiz |
Publisher |
: |
Total Pages |
: 426 |
Release |
: 1999 |
ISBN-10 |
: OCLC:895878345 |
ISBN-13 |
: |
Rating |
: 4/5 (45 Downloads) |
Synopsis The Synthesis and Evaluation of Novel Bioreductive Anticancer Agents by : Pilar Munoz Ruiz
Author |
: Wen-Chuan Hsu |
Publisher |
: |
Total Pages |
: |
Release |
: 1999 |
ISBN-10 |
: OCLC:59400020 |
ISBN-13 |
: |
Rating |
: 4/5 (20 Downloads) |
Synopsis The Synthesis and Investigation of Novel Bioreductive Anticancer Agents by : Wen-Chuan Hsu
Author |
: Qiao-Hong Chen |
Publisher |
: MDPI |
Total Pages |
: 606 |
Release |
: 2021-03-02 |
ISBN-10 |
: 9783036501406 |
ISBN-13 |
: 3036501401 |
Rating |
: 4/5 (06 Downloads) |
Synopsis Anticancer Agents by : Qiao-Hong Chen
This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Author |
: Xianrui Zhao |
Publisher |
: |
Total Pages |
: |
Release |
: 2009 |
ISBN-10 |
: OCLC:729399790 |
ISBN-13 |
: |
Rating |
: 4/5 (90 Downloads) |
Synopsis Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Applications to Tumor-targeting Drug Delivery Systems by : Xianrui Zhao
Author |
: Nicola Dione Henderson |
Publisher |
: |
Total Pages |
: 0 |
Release |
: 1994 |
ISBN-10 |
: OCLC:181867855 |
ISBN-13 |
: |
Rating |
: 4/5 (55 Downloads) |
Synopsis Synthesis and Biological Evaluation of Novel Anti-cancer Agents by : Nicola Dione Henderson
Author |
: A. A. R. A. Mal ullah |
Publisher |
: |
Total Pages |
: |
Release |
: 2020 |
ISBN-10 |
: OCLC:1230743059 |
ISBN-13 |
: |
Rating |
: 4/5 (59 Downloads) |
Synopsis Synthesis and Evaluation of Novel Heterocyclic Compounds as Anticancer Agents by : A. A. R. A. Mal ullah
Author |
: Larisa Kuznetsova |
Publisher |
: |
Total Pages |
: 584 |
Release |
: 2005 |
ISBN-10 |
: OCLC:66910143 |
ISBN-13 |
: |
Rating |
: 4/5 (43 Downloads) |
Synopsis Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Tumor Targeting Delivery by : Larisa Kuznetsova
Author |
: Jin Chen |
Publisher |
: |
Total Pages |
: 373 |
Release |
: 2006 |
ISBN-10 |
: 1109967381 |
ISBN-13 |
: 9781109967388 |
Rating |
: 4/5 (81 Downloads) |
Synopsis Design, Synthesis and Biological Evaluation of Novel Tumor-targeting Taxane-based Anticancer Agents by : Jin Chen
A novel series of the second-generation taxoid conjugates with o-3 polyunsaturated fatty acids (PUFA) such as docosahexanoic acid (DHA), linolenic acid (LNA) and linoleic acid (LA) has been successfully developed. The new conjugates, tested in vivo, exhibited strong activity against both resistant and sensitive colon and ovarian cancer xenografts. Two of the new conjugates (DHA-SB-T-1214 and DHA-SB-T-1213) caused the total regression of resistant and sensitive type cancers, respectively, with reduced side toxicity.
Author |
: Amit Kumar |
Publisher |
: |
Total Pages |
: |
Release |
: 2011 |
ISBN-10 |
: OCLC:1063701538 |
ISBN-13 |
: |
Rating |
: 4/5 (38 Downloads) |
Synopsis Synthesis and Biochemical Evaluation of Novel Enzyme Inhibitors as Potential Anti-tumour Agents in the Treatment of Breast Cancer by : Amit Kumar
Author |
: Omar Mohammed |
Publisher |
: |
Total Pages |
: |
Release |
: 2021 |
ISBN-10 |
: OCLC:1285709717 |
ISBN-13 |
: |
Rating |
: 4/5 (17 Downloads) |
Synopsis Design, Synthesis and Evaluation of Novel and Clinically Used Anti-cancer Agents Targeted Intracellularly by : Omar Mohammed