This second edition offers an expanded and updated history of the field of fetal and neonatal development, allowing readers to gain a comprehensive understanding of the biological aspects that contribute to the wellbeing or pathophysiology of newborns. In this concluding opus of a long and prominent career as a clinical scientist, Dr. Longo has invited new contributions from noted colleagues with expertise in various fields to provide a historical perspective on the impact of how modern concepts emerged in the field of fetal physiology and contributed to the current attention paid to the fetal origins of diseases in adults. In addition to new chapters on maternal physiology and complications during pregnancy, others trace the history of the Society for Reproductive Investigation, governmental funding of perinatal research, and major initiatives to support training in the new discipline of maternal fetal medicine, including the Reproductive Scientist Development program. The extensive survey provided by the author, who personally knew most of the pioneers in the field, offers a unique guide for all clinical and basic scientists interested in the history of – and future approaches to diagnosing and treating – pathologies that represent the leading causes of neonatal mortality and, far too often, life-long morbidity.

During the mid- to late-twentieth century, study of the physiology of the developing fetus and newborn infant evolved rapidly to become a major discipline in the biomedical sciences. Initially of interest from a standpoint of function of the placenta and oxygenation of the fetus, the field advanced to explore both normal functional mechanisms as well as pathophysiologic aspects of their regulation. Examples include studying the role and regulation of circulatory vascular anatomic shunts in oxygenation, cardiac function, certain aspects of asphyxia in the fetus and newborn infant, the role of fetal “breathing” movements, cyclic electroencephalographic activity, and analysis of electronic monitoring of fetal heart rate variability and its significance. Included in this book are reminisces of several dozen individuals who played a vital role in these developments. Overall, this survey considers a number of aspects of the development of the science of fetal and neonatal physiology, and its role in the greatly improved care of pregnant women and their newborn infants. This book is published on behalf of the American Physiological Society by Springer. Access to APS books published with Springer is free to APS members.

Fetal Physiology and Medicine: The Basis of Perinatology, Second, Revised Edition documents many of the major advances in fetal medicine, including developmental physiology, pathology, and therapy. This book covers the most important areas of maternofetal medicine and presents different views of the critical problems of development. The various components of fetal metabolism are highlighted to demonstrate how animal experimentation has given a clear view of the interrelationship of the mother, placenta, and fetus. This text is comprised of 24 chapters; the first of which describes the use of ultrasound in antenatal diagnosis of congenital structural anomalies. This topic is followed by a discussion on sexual differentiation, acquired immunity, and endocrine changes, as well as the physiology of breathing, the control of the fetal cardiovascular system, lung maturation, fetal infections, and the effects of hypoxia on the fetal brain. This book also provides comprehensive reviews of fetal regulatory mechanisms, such as the reninangiotensin system, water metabolism, and fetal and placental hormone production. Other chapters focus on clinical applications, such as antenatal fetal heart rate monitoring, the technical aspects of fetal and uterine pressure measurements, fetal acid-base balance, and the prevention of preterm delivery. A section that explores the transition from intrauterine to extrauterine life concludes this book. This source is of great potential value to all students and practitioners of reproductive medicine.

A fully updated and illustrated handbook providing comprehensive coverage of all curriculum areas covered by the MRCOG Part 1 examination.

**Selected for Doody's Core Titles® 2024 in Perinatal** Awarded first place in the 2018 AJN Book of the Year Awards in the Maternal-Child Health/Prenatal Nursing/ Childbirth category! Learn to provide the best prenatal, intrapartum, postpartum, and neonatal care possible. Maternal, Fetal, & Neonatal Physiology: A Clinical Perspective, 5th Edition includes expert insight and clinically relevant coverage of the physiologic changes that occur throughout all major periods of the perinatal experience. This classic reference gives you a solid foundation for assessment and therapeutic interventions, featuring an emphasis on the evolving interrelationships between mother, fetus, and neonate and adaptations of preterm and term infants to the extrauterine environment. - Solid coverage of the physiologic bases for assessment and therapeutic interventions make this an ideal resource for maternity, neonatal, women's health, or midwifery programs. - Synthesis of the latest research studies and evidence-based practice provides vital data on normal physiologic changes during the antepartum, intrapartum and postpartum periods; anatomic and functional development of the fetus; and developmental physiology of preterm and term neonates. - Coverage of pathophysiology and interventions for the pregnant woman, fetus, and newborn for selected abnormal events gives you a solid understanding of physiologic adaptations and developmental physiology relating to major body systems and metabolic processes. - Pharmacology tables offer quick access to key pharmacology information and drug effects with clinical examples. - NEW! Thoroughly updated content addresses the very latest practice issues and provides the basis for understanding physiologic adaptations in pregnant women, infants, and children. - NEW! Expanded coverage of maternal, fetal, neonatal, and pediatric physiology. - NEW! Soft cover and added color provide a contemporary look and feel.

This practical manual promotes an evidence-based paradigm of fetal heart rate monitoring during labour, moving away from the traditional 'pattern-based' interpretation to physiology-based interpretation. Aimed at obstetricians and midwives, it is useful to all those involved in multiprofessional intrapartum care.