Within the basic and clinical biomedical research community, there is increasing recognition that differences between males and females across the lifespan affect an individual's health, his/her development of disease, signs and symptoms of pathophysiology, and response to therapy. This book is intended as a resource for scientists, clinicians, and students of the nervous system and behavior- a trove of practical information about how to study sex differences in the brain as well as a discussion of what is already known on the topic.

First published in 1983. This book is primarily intended to make a theoretical contribution, to suggest a somewhat novel way of approaching the problems of human motivation, to break from tradition. The aim of this work is to stimulate the reader to think on a broad scale about big problems and to temper these thoughts with the detailed facts of empirical investigations.