The Proteins: Composition, Structure, and Function, Volume III, Second Edition is a collection of papers that deals with the proteins of antibodies and antigens, of the blood clotting system, plasma proteins, and the virus proteins. This volume also covers the fractionation of proteins and the criteria of purity, including the consideration of the interactions of proteins with radiant energy. One paper explains the peculiar biological usefulness and the special properties of each individual protein that can lead to its identification and separation. Other papers examine the structure and function of virus proteins, of viral nucleic acid, and of the plasma proteins. Another paper discuses the chemistry and structure of protein antigens and of antibodies, including the chemistry of their specific combination and relations with each other. The protein researcher can use convenient immunochemical techniques such as immunodiffusion and immunoelectrophoresis in his study. Other papers discuss the proteins in blood coagulation and the interactions of proteins with radiation, as well as, the infrared absorption spectra of proteins. This book can prove beneficial for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology or in cancer research.

Proteins: Structure and Function is a comprehensive introduction to the study of proteins and their importance to modern biochemistry. Each chapter addresses the structure and function of proteins with a definitive theme designed to enhance student understanding. Opening with a brief historical overview of the subject the book moves on to discuss the ‘building blocks’ of proteins and their respective chemical and physical properties. Later chapters explore experimental and computational methods of comparing proteins, methods of protein purification and protein folding and stability. The latest developments in the field are included and key concepts introduced in a user-friendly way to ensure that students are able to grasp the essentials before moving on to more advanced study and analysis of proteins. An invaluable resource for students of Biochemistry, Molecular Biology, Medicine and Chemistry providing a modern approach to the subject of Proteins.

The Proteins: Composition, Structure, and Function, Second Edition, Volume I explores the quantitative relationships between protein composition, structure, and function. This book is composed of six chapters that cover the rapid and fundamental advances in understanding protein chemistry. This book outlines first the quantitative procedures and various methods suitable for the determination of amino acids found as constituents of naturally occurring peptides and as free amino acids in tissues and body fluids. These topics are followed by a discussion on some of the aspects of peptide chemistry, which appear significant in relation to peptides possessing physiological activity. The next chapter considers protein synthesis that represents the sequences of chemical reactions whereby amino acids are assembled in biological systems to produce proteins. This volume also examines the correlation of structure with function; the mechanisms of control of protein biosynthesis; the exact role of intramolecular interactions in the determination of tertiary structure; and the colinearity of genetic "maps with amino acid sequences. A chapter describes the methods of analysis and reactions of sulfhydryl, disulfide, and thiol ester groups in proteins, as well as the evidence relating to the functions of these sulfur groups in proteins. The final chapter looks into the models and theories for the noncovalent bond interactions in proteins. This book is of value to organic chemists, biochemists, and researchers in the protein-related fields.

The Proteins: Composition, Structure, and Function, Second Edition, Volume IV covers the significant developments in understanding the relationships between the composition, structure, and function of proteins. This three-chapter volume deals first with the genetic determination of protein structure and with the effects of mutational alteration on the structure and function of proteins. A highly relevant aspect of this topic is the change in protein structure during evolution and cell development. The second chapter describes the basic structure of several glycoproteins, such as orosomucoid, egg albumin, and submaxillary gland glycoprotein. The third chapter highlights the features of composition and arrangement of the group protein, which impart the capacity to perform their physical function. This book is of value to organic chemists, biochemists, and researchers in the protein-related fields.

The Proteins: Composition, Structure, and Function, Second Edition, Volume II deals with fundamental properties of proteins, both in solution and in the solid state. This volume consists of five chapters that specifically cover the advances in understanding the structure and function of the protein molecule. The opening chapter presents interpretative procedures of experimental methods for determining protein conformation using X-ray crystallography, followed by an examination of the acid-base dissociations of proteins. The discussion then shifts to the investigation of interactions between protein molecules and other macromolecules, which is of significant importance in providing a chemical basis for many biological processes. A chapter considers first the synthesis, purification, and chemical properties of the polyamino acids. This chapter further describes their physicochemical properties in the solid state, in solution, and at interfaces, and lastly discusses their biological properties as high molecular weight substrates for proteolytic enzymes and as synthetic antigens, and their interaction with proteins and nucleic acids, with viruses, bacteria, blood components, and other biological systems. The use of polyamino acids in the study of the genetic code and the preparation and properties of polypeptidyl proteins are also covered. The concluding chapter focuses on X-ray analysis of protein structure. Organic chemists, biochemists, and researchers in protein-related fields will find this book invaluable

This volume surveys the current status of many of the important methods and approaches which are central to the study of protein structure and function. Many of the articles in this volume are written to emphasize the general utility of the method or approach which is at its core, and to provide sufficient literature references to enable the reader to adapt the method or approach to other applications. It is hoped that this volume will provide a source from which newcomers as well as experienced scient ists may becom& more familiar with recent developments and future trends in some of the important areas of protein research. The articles which comprise this book are selected proceedings from the Symposium of American Protein Chemists, which was held in San Diego, California, September 30 to October 3, 1985. The goal of the organizers of this first symposium was to provide a forum for discussion and inter action among scientists whose interests span the broad spectrum of protein structure and function research. The concept and timing of the symposium well received as evidenced by the approximately 500 delegates to the was symposium. The inaugural meeting was marked by a strong scientific pro gram with over 140 papers presented in either a lecture or poster format.

This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.