Using reported disasters and everyday examples, this book examines both natural and man-made chemicals that we are exposed to. Illuminating the world of toxicology, it explains how they are toxic and the different reactions that individuals have to them. It also aims to debunk the popular belief that 'Natural is good, Man-made is bad'.

Every day we are surrounded by chemicals that are potentially harmful. Some of these we take intentionally in the form of drugs; some we take unknowingly through the food we eat, and the environment around us. John Timbrell explores what makes particular chemicals harmful, what their effects are, and how we can test for them. He examines drugs such as Paracetamol and what it does to the body; Ricin, the most toxic substance known to man; Paraquat, a widely available weedkiller; and how the puffer fish, eaten as a delicacy in Japan, can kill. Using case studies from all around the world, such as the Spanish Oil syndrome which made over 20,000 people ill in Madrid, Timbrell uncovers the facts behind chemical scares. He shows how, with a rational, scientific, and balanced approach, risks can be assessed and managed safely.

We are assailed with scare stories about the chemical dangers lurking in our food, our homes, and the environ. This book explores how the chemicals that we use and that occur all around us can often be beneficial and yet under other circumstances can become poisons. By examining a variety of cases, from tragic disasters such as Bhopal and Minamata Bay, to the puffer fish which is at once poisonous and prized as a delicacy, this book explores the science of poisons: the different ways in which they harm us, and how they may be counteracted. By understanding the science of the poisons that we might encounter by accident or design, we can assess what the real risks are, and learn to live with them safely. Illustrations.

How can a plant as beautiful as the foxglove be so deadly and yet for more than a century be used to treat heart disease? The same is true of other naturally occurring molecules as will be revealed in this current book by award-winning author and chemist, John Emsley. More Molecules of Murder follows on from his highly-acclaimed earlier book Molecules of Murder, and again it deals with 14 potential poisons; seven of which are man-made and seven of which are natural. It investigates the crimes committed with them, not from the point of view of the murderers, their victims, or the detectives, but from the poison used. In so doing it throws new light on how these crimes were carried out and ultimately how the perpetrators were uncovered and brought to justice. Each chapter starts by looking at the target molecule itself, its discovery, its chemistry, its often-surprising use in medicine, its effects on the human body, and its toxicology. The rest of the chapter is devoted to murders and attempted murders in which it has been used. But, be reassured that murder by poison is not the threat it once was, thanks to laws which restrict access to such materials and to the skills of analytical chemists in detecting their presence in incredibly tiny amounts.

Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing. Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review.

Molecules of Murder is about infamous murderers and famous victims; about people like Harold Shipman, Alexander Litvinenko, Adelaide Bartlett, and Georgi Markov. Few books on poisons analyse these crimes from the viewpoint of the poison itself, doing so throws a new light on how the murders or attempted murders were carried out and ultimately how the perpetrators were uncovered and brought to justice. Part I includes molecules which occur naturally and were originally used by doctors before becoming notorious as murder weapons. Part II deals with unnatural molecules, mainly man-made, and they too have been dangerously misused in famous crimes. The book ends with the most famous poisoning case in recent years, that of Alexander Litvinenko and his death from polonium chloride. The first half of each chapter starts by looking at the target molecule itself, its discovery, its history, its chemistry, its use in medicine, its toxicology, and its effects on the human body. The second half then investigates a famous murder case and reveals the modus operandi of the poisoner and how some were caught, some are still at large, and some literally got away with murder. Molecules of Murder will explain how forensic chemists have developed cunning ways to detect minute traces of dangerous substances, and explain why some of these poisons, which appear so life-threatening, are now being researched as possible life-savers. Award winning science writer John Emsley has assembled another group of true crime and chemistry stories to rival those of his highly acclaimed Elements of Murder.

This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology's subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools.Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology's presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field.The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children's environmental health. - Opens with an overview of the international toxicology scene, organizations and activities involved with both the science and regulatory framework, and a specific look at the European Union's efforts - Offers an extensive collection of chapters covering over 40 countries and their toxicological infrastructure which includes listings of major books and journals, organizations, professional societies, universities, poison control centers, legislation, and online databases - Provides the Second Edition of the International Union of Pure and Applied Chemistry's Glossary of Terms Used in Toxicology, a carefully constructed and peer reviewed collation of critical terms in the science - Concludes with a potpourri of quotes concerning toxicology and their use in the arts and popular culture - Paired with Volume One, which offers chapters on a host of toxicology sub-disciplines, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over120 chapters contributions by experts and leaders in the field

Dangerous, dark and difficult to detect, poisons have been a common character in literature from ancient times to the modern day. Their ability to perform deadly deeds at a distance is a common device for creating dramatic tension and playing on our real life fears. But what is fact and what is pure fiction? From Shakespeare and Dickens to Hugo and Poe, the macabre world of literary poisonings is as large as it is fascinating. Utilising real forensic science Poisonous Tales explores the real science inspiring the toxins and tinctures in our favourite works. Could a poison really mimic death in Romeo and Juliet? What is the cause of the mad Hatter’s malady in Alice in Wonderland? And could a stone from the stomach of a goat really have been used as an antidote in Harry Potter and the Half-Blood Prince? Through these and many more ‘cases’ we discover the captivating truth in the texts and how real-life tragedies can replicate themselves in fiction.

It is London in the 1890s. A young woman has just taken a dose of a tonic she’s been given in the belief that it will improve her complexion. About ten minutes pass and she starts to experience breathing difficulties. Another minute and she collapses. Mercifully, death arrives but the poison has not yet finished, for the process of rigor mortis has set in with unusual speed. Her body is frozen into a rigid and contorted mass. This is the horror of strychnine, the nastiest of poisons. Despite knowing all the dreadfulness of this poison, Dr Thomas Neill Cream, the Lambeth Poisoner, used it to kill several prostitutes. And who knows how many other victims experienced the horror of strychnine, for it was by no means an uncommon poison. Today, there may well be more poisons available to the individual than ever before, but there are also advances in medical examination and forensic analysis that increase the likelihood of the poisoner being caught. This book will examine poisons, both natural and man-made menaces, and cases based on a particular poison as well as information about how forensic analysis is conducted. Appealing to scientists and non-scientists alike, this enthralling book will entertain and educate and bring the reader up to date with how important chemical analysis is in crime detection.