This book reviews the research pertaining to nutrient requirements for working in cold or in high-altitude environments and states recommendations regarding the application of this information to military operational rations. It addresses whether, aside from increased energy demands, cold or high-altitude environments elicit an increased demand or requirement for specific nutrients, and whether performance in cold or high-altitude environments can be enhanced by the provision of increased amounts of specific nutrients.

The activities of the Food and Nutrition Board's Committee on Military Nutrition Research (CMNR, the committee) have been supported since 1994 by grant DAMD17-94-J-4046 from the U.S. Army Medical Research and Materiel Command (USAMRMC). This report fulfills the final reporting requirement of the grant, and presents a summary of activities for the grant period from December 1, 1994 through May 31, 1999. During this grant period, the CMNR has met from three to six times each year in response to issues that are brought to the committee through the Military Nutrition and Biochemistry Division of the U.S. Army Research Institute of Environmental Medicine at Natick, Massachusetts, and the Military Operational Medicine Program of USAMRMC at Fort Detrick, Maryland. The CMNR has submitted five workshop reports (plus two preliminary reports), including one that is a joint project with the Subcommittee on Body Composition, Nutrition, and Health of Military Women; three letter reports, and one brief report, all with recommendations, to the Commander, U.S. Army Medical Research and Materiel Command, since September 1995 and has a brief report currently in preparation. These reports are summarized in the following activity report with synopses of additional topics for which reports were deferred pending completion of military research in progress. This activity report includes as appendixes the conclusions and recommendations from the nine reports and has been prepared in a fashion to allow rapid access to committee recommendations on the topics covered over the time period.

Leading authorities on high-altitude physiology contribute to this work, which is divided into three sections: Man at Extreme Altitude; Sleep and Restoration at High Altitude; and Physiology of Permanent Residents of High Altitude. Based on a symposium on physiology at high altitude sponsored by the American Physiological Society, the volume includes several chapters on the achievements of the 1981 American Medical Research Expedition to Mt. Everest, where the first physiological measurements at altitudes above 8,000 meters were recorded. With growing interest in the study of human performance in these conditions, this text marks a lasting achievement in high-altitude physiology.

​ Over the last decade the science and medicine of high altitude and hypoxia adaptation has seen great advances. High Altitude: Human Adaptation to Hypoxia addresses the challenges in dealing with the changes in human physiology and the particular medical conditions that arise from exposure to high altitude. In-depth and comprehensive chapters cover both the basic science and the clinical consequences of exposure to high altitude. Genetic, cellular, organ and whole body system responses to high altitudes are covered and chapters discuss these effects on a wide range of diseases. Expert authors provide insight into the care of patients with pre-existing medical conditions that fail in some cases to adapt as well as offer insights into how high altitude research can help critically ill patients. High Altitude: Human Adaptation to Hypoxia is an important new volume that offers a window into greater understanding and more successful treatment of hypoxic human diseases.

High altitude physiology and medicine has again become important. The excep tional achievements of mountaineers who have climbed nearly all peaks over 8,000 m without breathing equipment raise the question of maximal adaptation ca pacity of man to low oxygen pressures. More importantly, the increase in tourism in the Andes and the Himalayas brings over 10,000 people to sites at altitudes above 4,000 and 5,000 m each year. At such heights several kinds of high alti tude diseases are likely to occur, and these complications require detailed medical investigations. Medical authorities need to inform both mountaineers and tourists as to how great a physical burden can be taken in the mountain environment without risk to health. Physicians need to know what kind of prophylaxis is to be employed at high altitudes to prevent the development of diseases and what therapeutic measures should be used once high altitude diseases have occurred. Moreover, the physical condition of the indigenous population living at higher altitudes such as the Andes and the Himalayas, who are exposed continuously to the stress of high altitude, requires our attention. We have become familiar with symptoms characteristic of chronic high-altitude disease: under special conditions this popu lation has a tendency to develop pulmonary hypertension, which is associated with pulmonary edema, pulmonary congestion, and right heart failure.

A comprehensive update to this preeminent and accessible text, this fifth edition of a bestseller was developed as a response to man's attempts to climb unaided to higher altitudes and to spend more time in these conditions for both work and recreation. It describes the ever-expanding challenges that doctors face in dealing with the changes in huma

HE history of high-altitude physiology and medicine is such a rich and T colorful topic that it is perhaps surprising that no one has undertaken a comprehensive account before. There are so many interesting ramifications, from the early balloonists to the various high-altitude expeditions, culminating in the great saga of climbing Mt. Everest without supplementary oxygen. Underpinning this variety is the basic biological challenge of hypoxia and the ways organisms adapt to it, a subject that is of key importance in medicine and many other life sciences, encountered as it is by organisms throughout the animal kingdom. I hope that this book will be of interest to a wide range of people, from biologists and physiologists to pulmonologists and others who manage patients with hypoxemia. The topic should also appeal to those who love the mountains including trekkers, skiers, climbers, and mountaineers. The book begins with a short introductory chapter to set the scene for the non-scientist. It then follows a general chronological sequence beginning with the Greeks and ending with contemporary events. In some places, however some compromises have been made to group together areas of related interest. For example, in Chapter 4 the controversy about oxygen secretion is traced from the 1870s to the 1930s and includes the Anglo-American Pikes Peak Ex pedition of 1911 and the International High-Altitude Expedition to Cerro de Pasco, Peru during 1921-1922. It makes sense to consider these events together.

Management of High Altitude Pathophysiology presents a comprehensive overview on the various therapeutic practices and ongoing research relating to the development of more potent and novel formulations for managing high altitude pathophysiology. It provides a detailed application of both herbal and non-herbal therapeutic agents, including their nanoformulations. This important reference provides benefits to the medical and herbal scientific communities, doctors treating patients with high altitude complications, individuals travelling to high altitudes for recreation or work, and scientists working on future drug development. - Provides the recent advances and potential therapeutic agents for ameliorating the high-altitude complications - Includes herbal remedies for the prophylaxis and treatment of the high-altitude maladies - Elucidates the significance of Yogic practices and ergonomics in managing stress at high altitude

A practical review of the essentials of anesthesia for physicians in austere environments and providing healthcare to disaster survivors.