Draws on the latest scientific findings to identify the unique characteristics, chemical makeups, and structural differences of migraine-prone brains, offering insight into the role of the central nervous system while outlining a comprehensive program to reduce the frequency and intensity of headaches. Reprint.

Roughly one in every five patients referred to a neurologist suffers from headaches; the majority have migraines. Although headache specialists understand migraine on a clinical basis, the pathophysiological changes that provoke and accompany the development of a migraine attack continue to elude us. Several decades have passed since the pioneering electroencephalographic study by Golla and Winter (1959), which underscored the role of abnormal rhythmic activities in migraine. Since then, there have been substantial advances in the field; a wealth of neurophysiological studies has enriched our understanding of the pathophysiological facets of the migraine pathology. Virtually every known technique of clinical electrophysiology has since been used to study the migraine brain and, more recently, new neurophysiological tools have been added to the arsenal. Nevertheless, applying the principles of peripheral and central neuromodulation offers a promising way to transfer the principles of synaptic plasticity to the patient’s bedside. This book belongs to the Headache Series endorsed by the European Headache Federation. Written by internationally recognized experts in their respective fields, it covers all aspects of clinical neurophysiological methods that represent significant advances in our understanding of the pathophysiology of migraine. It will offer a valuable toolkit for beginners, and a reference guide for experts.

With more than one in ten Americans -- and more than one in five families -- affected, the phenomenon of migraine is widely prevalent and often ignored or misdiagnosed. By his mid-forties, Andrew Levy's migraines were occasional reminders of a persistent illness that he'd wrestled with half his life, though he had not fully contemplated their physical and psychological influence on the individual, family, and society at large. Then in 2006 Levy was struck almost daily by a series of debilitating migraines that kept him essentially bedridden for months, imprisoned by pain and nausea that retreated only briefly in gentler afternoon light. When possible, Levy kept careful track of what triggered an onset -- the "thin, taut" pain from drinking a bourbon, the stabbing pulse brought on by a few too many M&M's -- and in luminous prose recounts his struggle to live with migraines, his meticulous attempts at calibrating his lifestyle to combat and avoid them, and most tellingly, the personal relationship a migraineur develops -- an almost Stockholm syndrome-like attachment -- with the indescribable pain, delirium, and hallucinations. Levy read about personalities and artists throughout history with migraine -- Alexander Pope, Nietzsche, Freud, Virginia Woolf, even Elvis -- and researched the treatments and medical advice available for migraine sufferers. He candidly describes his rehabilitation with the aid of prescription drugs and his eventual reemergence into the world, back to work and writing. An enthralling blend of memoir and provocative analysis, A Brain Wider Than the Sky offers rich insights into an illness whose effects are too often discounted and whose sufferers are too often overlooked.

Despite their widespread occurrence, migraines are often misunderstood in terms of both origin and treatment. Shifflett examines the causes of these painful headaches, many of which can be corrected by the individual. The author defines the roots and symptoms of migraines as well as the interactions between the source of pain and the rest of the body.

From the renowned neurologist and bestselling author of Awakenings and The Man Who Mistook His Wife for a Hat comes a fascinating investigation of the many manifestations of migraine, including the visual hallucinations and distortions of space, time, and body image which migraineurs can experience. “So erudite, so gracefully written, that even those people fortunate enough never to have had a migraine in their lives should find it equally compelling.” —The New York Times The many manifestations of migraine can vary dramatically from one patient to another, even within the same patient at different times. Among the most compelling and perplexing of these symptoms are the strange visual hallucinations and distortions of space, time, and body image which migraineurs sometimes experience. Portrayals of these uncanny states have found their way into many works of art, from the heavenly visions of Hildegard von Bingen to Alice in Wonderland. Dr. Oliver Sacks argues that migraine cannot be understood simply as an illness, but must be viewed as a complex condition with a unique role to play in each individual's life.

The Migraine Brain provides a general overview of the history of migraine, its pathophysiology, as well as in-depth details on the Clinical Perspectives and the different imaging techniques in use (MR, fMRI, DTI, VBM, PET, fMRI, and MEG). It also includes details on modulation of the brain using such techniques as TMS. The book concludes with a discussion of future uses of imaging in the diagnosis and treatment of migraines and other headaches.

A cultural, social, and medical history of migraine. For centuries, people have talked of a powerful bodily disorder called migraine, which currently affects about a billion people around the world. Yet until now, the rich history of this condition has barely been told. In Migraine, award-winning historian Katherine Foxhall reveals the ideas and methods that ordinary people and medical professionals have used to describe, explain, and treat migraine since the Middle Ages. Touching on classical theories of humoral disturbance and medieval bloodletting, Foxhall also describes early modern herbal remedies, the emergence of neurology, and evolving practices of therapeutic experimentation. Throughout the book, Foxhall persuasively argues that our current knowledge of migraine's neurobiology is founded on a centuries-long social, cultural, and medical history. This history, she demonstrates, continues to profoundly shape our knowledge of this complicated disease, our attitudes toward people who have migraine, and the sometimes drastic measures that we take to address pain. Migraine is an intimate look at how cultural attitudes and therapeutic practices have changed radically in response to medical and pharmaceutical developments. Foxhall draws on a wealth of previously unexamined sources, including medieval manuscripts, early-modern recipe books, professional medical journals, hospital case notes, newspaper advertisements, private diaries, consultation letters, artworks, poetry, and YouTube videos. Deeply researched and beautifully written, this fascinating and accessible study of one of our most common, disabling—and yet often dismissed—disorders will appeal to physicians, historians, scholars in medical humanities, and people living with migraine alike.

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Navigating Life with Migraine and Other Headaches focuses on the many myths that exist around headaches and dispels common misperceptions by providing simple explanations on how headaches occur, and, most importantly, how to treat them. The authors give real, practical advice: when and how to manage your headaches, when to seek treatment, and when to be concerned. From vitamins to prescription meds; from when to go to the emergency department to optimizing doctor visits; options for managing headaches are presented in this accessible and easy-to-read resource. The more you know about headache, including the mechanisms that cause pain, the better you and your family can manage this common and chronic condition. Through the use of patient stories, a glossary of terms for easy reference, and key points for quick retention, this book is a high-quality resource for people looking for empowerment and a sense of control.

Migraine is an extraordinarily common, disabling, and painful disorder that affects over 36 million Americans and costs the US economy at least $32 billion per year. Nevertheless, it is frequently dismissed, ignored, and delegitimised. In this book, Joanna Kempner argues that this general dismissal of migraine can be traced back to the gendered social values embedded in the way we talk about, understand, and make policies for people in pain.