ORIGINAL SIN Piers Rameau, a brilliant geneticist, was offered the chance to help design mankind's replacement--Original Man, a smarter, stronger, swifter race based on manipulated human DNA. But Rameau refused, and chose to follow his own path. Now Kuno Gunnarsson, creator of Original Man and Rameau's would-be employer, is dead--but his superior creation lives on. And one faction of Original Man is determined to wrest control of the galaxy from the inferior race. A brutal attack destroys both Rameau's home planet and the satellite that has become his world. One tragic casualty is Dakini, a fragile, genetically altered dancer who had become Rameau's reason to live. The sole survivor, he finds himself a prisoner of Gunnarsson Prime, a clone of the original creator, on board the Jumpship Langstaff. Against his will, Rameau is enlisted as the ship's wartime medical officer. As a doctor, he swore an oath to do no harm. As a man, he swears blood vengeance on the inhuman killers who destroyed everything he ever loved . . . .

National Bestseller National Book Critics Circle Award Nominee From the Pulitzer Prize–winning author of The Overstory and the forthcoming Bewilderment, a magnificent double love story of two young couples separated by a distance of twenty-five years. “The most lavishly ambitious American novel since Gravity’s Rainbow . . . An outright marvel.” —Washington Post Stuart Ressler, a brilliant young molecular biologist, sets out in 1957 to crack the genetic code. His efforts are sidetracked by other, more intractable codes—social, moral, musical, spiritual—and he falls in love with a member of his research team. Years later, another young man and woman team up to investigate a different scientific mystery: Why did the eminently promising Ressler suddenly disappear from the world of science? Strand by strand, these two love stories twist about each other in a double helix of desire. The critically acclaimed third novel from Pulitzer Prize–winning author Richard Powers, The Gold Bug Variations is an intellectual tour-de-force that probes the meaning of love, science, music, and art.

“Venter instills awe for biology as it is, and as it might become in our hands.” —Publishers Weekly On May 20, 2010, headlines around the world announced one of the most extraordinary accomplishments in modern science: the creation of the world’s first synthetic lifeform. In Life at the Speed of Light, scientist J. Craig Venter, best known for sequencing the human genome, shares the dramatic account of how he led a team of researchers in this pioneering effort in synthetic genomics—and how that work will have a profound impact on our existence in the years to come. This is a fascinating and authoritative study that provides readers an opportunity to ponder afresh the age-old question “What is life?” at the dawn of a new era of biological engineering.

Sci-fi master Theodore Sturgeon wrote stories with power and freshness, and in telling them created a broader understanding of humanity—a legacy for readers and writers to mine for generations. Along with the title story, the collection includes stories written between 1953 and 1955, Sturgeon's greatest period, with such favorites as "Bulkhead," "The Golden Helix," and "To Here and the Easel."

Mike Knight, an executive in a semiconductor firm, learns that his eight-year-old son Tim has a rare form of brain cancer. Tim's best hope for long-term survival is a drug called Supragrel. Unfortunately, Supragrel is still in early clinical trials and may reach the market too late. Mike makes the agonizing decision to quit his job and go to work for Altus Labs, the developer of Supragrel, in hopes of helping them bring the drug to market more quickly. Mike is in for the challenge of his life as he struggles to keep his family together while racing against time to implement world-class project management in Altus Labs. Critical Chain Project Management is a superior project management process that has been quietly implemented in some of the world's best-known companies for over a decade. This book tells you the story of a Critical Chain Project Management implementation. The venue is a major pharmaceutical company, but it could happen anywhere in corporate America.

Data in the genomics field is booming. In just a few years, organizations such as the National Institutes of Health (NIH) will host 50+ petabytesâ??or over 50 million gigabytesâ??of genomic data, and theyâ??re turning to cloud infrastructure to make that data available to the research community. How do you adapt analysis tools and protocols to access and analyze that volume of data in the cloud? With this practical book, researchers will learn how to work with genomics algorithms using open source tools including the Genome Analysis Toolkit (GATK), Docker, WDL, and Terra. Geraldine Van der Auwera, longtime custodian of the GATK user community, and Brian Oâ??Connor of the UC Santa Cruz Genomics Institute, guide you through the process. Youâ??ll learn by working with real data and genomics algorithms from the field. This book covers: Essential genomics and computing technology background Basic cloud computing operations Getting started with GATK, plus three major GATK Best Practices pipelines Automating analysis with scripted workflows using WDL and Cromwell Scaling up workflow execution in the cloud, including parallelization and cost optimization Interactive analysis in the cloud using Jupyter notebooks Secure collaboration and computational reproducibility using Terra

As staff writer for Scientific American, John Horgan has a window on contemporary science unsurpassed in all the world. Who else routinely interviews the likes of Lynn Margulis, Roger Penrose, Francis Crick, Richard Dawkins, Freeman Dyson, Murray Gell-Mann, Stephen Jay Gould, Stephen Hawking, Thomas Kuhn, Chris Langton, Karl Popper, Stephen Weinberg, and E.O. Wilson, with the freedom to probe their innermost thoughts? In The End Of Science, Horgan displays his genius for getting these larger-than-life figures to be simply human, and scientists, he writes, "are rarely so human . . . so at there mercy of their fears and desires, as when they are confronting the limits of knowledge."This is the secret fear that Horgan pursues throughout this remarkable book: Have the big questions all been answered? Has all the knowledge worth pursuing become known? Will there be a final "theory of everything" that signals the end? Is the age of great discoverers behind us? Is science today reduced to mere puzzle solving and adding detains to existing theories? Horgan extracts surprisingly candid answers to there and other delicate questions as he discusses God, Star Trek, superstrings, quarks, plectics, consciousness, Neural Darwinism, Marx's view of progress, Kuhn's view of revolutions, cellular automata, robots, and the Omega Point, with Fred Hoyle, Noam Chomsky, John Wheeler, Clifford Geertz, and dozens of other eminent scholars. The resulting narrative will both infuriate and delight as it mindless Horgan's smart, contrarian argument for "endism" with a witty, thoughtful, even profound overview of the entire scientific enterprise. Scientists have always set themselves apart from other scholars in the belief that they do not construct the truth, they discover it. Their work is not interpretation but simple revelation of what exists in the empirical universe. But science itself keeps imposing limits on its own power. Special relativity prohibits the transmission of matter or information as speeds faster than that of light; quantum mechanics dictates uncertainty; and chaos theory confirms the impossibility of complete prediction. Meanwhile, the very idea of scientific rationality is under fire from Neo-Luddites, animal-rights activists, religious fundamentalists, and New Agers alike. As Horgan makes clear, perhaps the greatest threat to science may come from losing its special place in the hierarchy of disciplines, being reduced to something more akin to literaty criticism as more and more theoreticians engage in the theory twiddling he calls "ironic science." Still, while Horgan offers his critique, grounded in the thinking of the world's leading researchers, he offers homage too. If science is ending, he maintains, it is only because it has done its work so well.

Lorelei of the Red Mist: Planetary Romances is the companion volume to Martian Quest: The Early Brackett, a volume that collected the First twenty published stories by the ?undisputed Queen of ?Space Opera.? ?With the stories in this volume, Brackett takes the foundation of the Fictional universe established in her early work, and populates these worlds with colorful characters and locales teeming with adventure and intrigue. Here, hard-bitten and cynical rogues risk (and sometimes lose) all to battle stellar horrors, escape from decadent tyrannies, and yes, rescue the girl.During the timeframe when these stories were written, Brackett First broke into writing screenplays for Hollywood. With only modest success for Republic Pictures, it was on the strength of her First mystery novel that she was offered to co-author the screenplay for Warner Bros.? The Big Sleep with William Faulkner by director Howard Hawks.Appropriately, Lorelei of the Red Mist: Planetary Romances features an introduction by a protege of Leigh Brackett, a one-time collaborator (on this volume?s title story) and 2004 recipient of the National Medal of Arts, Ray Bradbury.