Dealing with dynamics of processes that repeat themselves regularly, this revised and updated edition extends the thread from 1980 to the present day, concentrating on areas of interest where there will be much activity in the future. This involves going through spatial biochemical, electrophysiological, and organismic dynamical systems and patterns that were discovered by pursuing the theme of phase singularities introduced in the original book. In particular the work on excitability in cell membranes will be thoroughly updated as will the references throughout the book.

This authored monograph introduces a genuinely theoretical approach to biology. Starting point is the investigation of empirical biological scaling including their variability, which is found in the literature, e.g. allometric relationships, fractals, etc. The book then analyzes two different aspects of biological time: first, a supplementary temporal dimension to accommodate proper biological rhythms; secondly, the concepts of protension and retention as a means of local organization of time in living organisms. Moreover, the book investigates the role of symmetry in biology, in view of its ubiquitous importance in physics. In relation with the notion of extended critical transitions, the book proposes that organisms and their evolution can be characterized by continued symmetry changes, which accounts for the irreducibility of their historicity and variability. The authors also introduce the concept of anti-entropy as a measure for the potential of variability, being equally understood as alterations in symmetry. By this, the book provides a mathematical account of Gould's analysis of phenotypic complexity with respect to biological evolution. The target audience primarily comprises researchers interested in new theoretical approaches to biology, from physical, biological or philosophical backgrounds, but the book may also be beneficial for graduate students who want to enter this field.

A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid

Winner of a British Medical Association Book Award A Brain Pickings Best Science Book of the Year Early birds and night owls are born, not made. Sleep patterns may be the most obvious manifestation of the highly individualized biological clocks we inherit, but these clocks also regulate bodily functions from digestion to hormone levels to cognition. Living at odds with our internal timepieces, Till Roenneberg shows, can make us chronically sleep deprived and more likely to smoke, gain weight, feel depressed, fall ill, and fail geometry. By understanding and respecting our internal time, we can live better. “Internal Time is a cautionary tale—actually a series of 24 tales, not coincidentally. Roenneberg ranges widely from the inner workings of biological rhythms to their social implications, illuminating each scientific tutorial with an anecdote inspired by clinical research...Written with grace and good humor, Internal Time is a serious work of science incorporating the latest research in chronobiology...[A] compelling volume.” —A. Roger Ekirch, Wall Street Journal “This is a fascinating introduction to an important topic, which will appeal to anyone who wishes to delve deep into the world of chronobiology, or simply wonders why they struggle to get a good night’s sleep.” —Richard Wiseman, New Scientist

Fractal Geometry in Biological Systems was written by the leading experts in the field of mathematics and the biological sciences together. It is intended to inform researchers in the bringing about the fundamental nature of fractals and their widespread appearance in biological systems. The chapters explain how the presence of fractal geometry can be used in an analytical way to predict outcomes in systems, to generate hypotheses, and to help design experiments. The authors make the mathematics accessible to a wide audience and do not assume prior experience in this area.

The Description for this book, When Time Breaks Down: The Three-Dimensional Dynamics of Electrochemical Waves and Cardiac Arrhythmias, will be forthcoming.

This is the only book that teaches all aspects of modern mathematical modeling and that is specifically designed to introduce undergraduate students to problem solving in the context of biology. Included is an integrated package of theoretical modeling and analysis tools, computational modeling techniques, and parameter estimation and model validation methods, with a focus on integrating analytical and computational tools in the modeling of biological processes. Divided into three parts, it covers basic analytical modeling techniques; introduces computational tools used in the modeling of biological problems; and includes various problems from epidemiology, ecology, and physiology. All chapters include realistic biological examples, including many exercises related to biological questions. In addition, 25 open-ended research projects are provided, suitable for students. An accompanying Web site contains solutions and a tutorial for the implementation of the computational modeling techniques. Calculations can be done in modern computing languages such as Maple, Mathematica, and MATLAB?.

An instant New York Times Bestseller! “Unreasonably entertaining . . . reveals how geometric thinking can allow for everything from fairer American elections to better pandemic planning.” —The New York Times From the New York Times-bestselling author of How Not to Be Wrong—himself a world-class geometer—a far-ranging exploration of the power of geometry, which turns out to help us think better about practically everything. How should a democracy choose its representatives? How can you stop a pandemic from sweeping the world? How do computers learn to play Go, and why is learning Go so much easier for them than learning to read a sentence? Can ancient Greek proportions predict the stock market? (Sorry, no.) What should your kids learn in school if they really want to learn to think? All these are questions about geometry. For real. If you're like most people, geometry is a sterile and dimly remembered exercise you gladly left behind in the dust of ninth grade, along with your braces and active romantic interest in pop singers. If you recall any of it, it's plodding through a series of miniscule steps only to prove some fact about triangles that was obvious to you in the first place. That's not geometry. Okay, it is geometry, but only a tiny part, which has as much to do with geometry in all its flush modern richness as conjugating a verb has to do with a great novel. Shape reveals the geometry underneath some of the most important scientific, political, and philosophical problems we face. Geometry asks: Where are things? Which things are near each other? How can you get from one thing to another thing? Those are important questions. The word "geometry"comes from the Greek for "measuring the world." If anything, that's an undersell. Geometry doesn't just measure the world—it explains it. Shape shows us how.

This volume develops a unifying approach to population studies, emphasising the interplay between modelling and experimentation. Throughout, mathematicians and biologists are provided with a framework within which population dynamics can be fully explored and understood. Aspects of population dynamics covered include birth-death and logistic processes, competition and predator-prey relationships, chaos, reaction time-delays, fluctuating environments, spatial systems, velocities of spread, epidemics, and spatial branching structures. Both deterministic and stochastic models are considered. Whilst the more theoretically orientated sections will appeal to mathematical biologists, the material is presented so that readers with little mathematical expertise can bypass these without losing the main flow of the text.