The #1 New York Times–bestselling author’s classic novel of life and death drama inside a major American hospital—“easy to read and hard to stop reading” (Kirkus Reviews). Change is in the air when a new board chairman sets out to modernize and expand Three Counties Hospital in Burlington, Pennsylvania—a once venerable institution whose standards have slipped. Dynamic Dr. Kent O’Donnell, a Harvard Medical School–trained surgeon, accepts the board’s offer to lead and reform the rundown, disorganized hospital because he wants to make his mark on the world. As medical-board president, O’Donnell faces his greatest challenge in Dr. Joe Pearson, Three Counties’ elderly head pathologist. Once an excellent diagnostician, Pearson is now out of touch with the latest research and procedures in laboratory medicine. But if the hospital lets the imperious doctor go, it risks losing an important benefactor’s financial support. Arthur Hailey’s fascinating, dramatic, and scrupulously researched story reveals both the professional, personal, and romantic aspects of an administrator-surgeon’s life, as well as the tragedies and moments of joy that occur every day in a hospital—a place where life often begins and ends.

A riveting exploration of the most difficult and important part of what doctors do, by Yale School of Medicine physician Dr. Lisa Sanders, author of the monthly New York Times Magazine column "Diagnosis," the inspiration for the hit Fox TV series House, M.D. "The experience of being ill can be like waking up in a foreign country. Life, as you formerly knew it, is on hold while you travel through this other world as unknown as it is unexpected. When I see patients in the hospital or in my office who are suddenly, surprisingly ill, what they really want to know is, ‘What is wrong with me?’ They want a road map that will help them manage their new surroundings. The ability to give this unnerving and unfamiliar place a name, to know it—on some level—restores a measure of control, independent of whether or not that diagnosis comes attached to a cure. Because, even today, a diagnosis is frequently all a good doctor has to offer." A healthy young man suddenly loses his memory—making him unable to remember the events of each passing hour. Two patients diagnosed with Lyme disease improve after antibiotic treatment—only to have their symptoms mysteriously return. A young woman lies dying in the ICU—bleeding, jaundiced, incoherent—and none of her doctors know what is killing her. In Every Patient Tells a Story, Dr. Lisa Sanders takes us bedside to witness the process of solving these and other diagnostic dilemmas, providing a firsthand account of the expertise and intuition that lead a doctor to make the right diagnosis. Never in human history have doctors had the knowledge, the tools, and the skills that they have today to diagnose illness and disease. And yet mistakes are made, diagnoses missed, symptoms or tests misunderstood. In this high-tech world of modern medicine, Sanders shows us that knowledge, while essential, is not sufficient to unravel the complexities of illness. She presents an unflinching look inside the detective story that marks nearly every illness—the diagnosis—revealing the combination of uncertainty and intrigue that doctors face when confronting patients who are sick or dying. Through dramatic stories of patients with baffling symptoms, Sanders portrays the absolute necessity and surprising difficulties of getting the patient’s story, the challenges of the physical exam, the pitfalls of doctor-to-doctor communication, the vagaries of tests, and the near calamity of diagnostic errors. In Every Patient Tells a Story, Dr. Sanders chronicles the real-life drama of doctors solving these difficult medical mysteries that not only illustrate the art and science of diagnosis, but often save the patients’ lives.

Terrorists target a TV anchorman and his family in the #1 New York Times–bestselling author’s novel set in the high-pressure network news industry. Anchorman Crawford Sloane, a respected reporter who made his name as a Vietnam War correspondent, thrives on the unpredictability of life in the newsroom. Whether he’s covering the imminent crash of an airliner in distress, terror in South America, or riots in Eastern Europe, or dealing with the cold-blooded politics of one of America’s premier news organizations, he never loses his cool. With terrorism dominating the evening news, Sloane takes precautions because he knows that as the face of American democracy, he’s a prime target for radicals. But when terrorists kidnap his family, he’s no longer reporting the news; he’s living it. Unwilling to rely on the help of ruthless network executives or the intrepid reporter who was once a rival for the affections of his wife, Sloane sets out to track down the kidnappers himself—and he soon learns that pure terror can lie behind the headlines.

It's a massive hospital space station on the Galactic rim--384 levels, a staff of thousands--where human and alien medicine meet. But Patient Hewlitt, new to Sector General, doesn't want to meet alien medicine--or alien doctors, or alien nurses, or aliens of any kind. Which is just too bad; he's an interesting case, and he'll have to get used to it. In the meantime, it's always been an article of faith among Sector General's multispecies staff that infections can't pass from one alien race to another. But in this season of anomalies, it looks like they might have their first-ever interstellar virus on their hands, their tentacles, their cilla.... Combining intrigue, ingenious puzzles (and even more ingenious solutions), action, adventure and White's characteristic easy charm, Final Diagnosis is a science-fiction treat.

Haematology Diagnostic haematology requires the assessment of clinical and laboratory data together with a careful morphological assessment of cells in blood, bone marrow and tissue ­fluids. Subsequent investigations including flow cytometry, immunohistochemistry, cytogenetics and molecular studies are guided by the original morphological findings. These targeted investigations help generate a prompt unifying diagnosis. Haematology: From the Image to the Diagnosis presents a series of cases illustrating how skills in morphology can guide the investigative process. In this book, the authors capture a series of images to illustrate key features to recognize when undertaking a morphological review and show how they can be integrated with supplementary information to reach a final diagnosis. Using a novel format of visual case studies, this text mimics ‘real life’ for the practising diagnostic haematologist – using brief clinical details and initial microscopic morphological triage to formulate a differential diagnosis and a plan for efficient and economical confirmatory investigation to deduce the correct final diagnosis. The carefully selected, high-quality photomicrographs and the clear, succinct descriptions of key features, investigations and results will help haematologists, clinical scientists, haematology trainees and haematopathologists to make accurate diagnoses in their day-to-day work. Covering a wide range of topics, and including paediatric as well as adult cases, Haematology: From the Image to the Diagnosis is a succinct visual guide which will be welcomed by consultants, trainees and scientists alike.

British Medical Association Book Awards 2009 - First Prize Winner, Primary Care Category Evidence-Based Diagnosis in Primary Care provides guidance on diagnosis in general practice, from the patient’s first presentation with a symptom to the final establishment of a diagnosis or referral for further investigation. The book is divided into two parts: • Symptoms; which details the steps necessary to reach a provisional diagnosis when a patient presents; and • Disorders; in which the more detailed assessment of that initial diagnosis is described. This is the first book to be written about diagnosis in primary care that attempts to base its guidance on the research evidence. Enough information is provided on each symptom, or condition, to decide on the pre-test probability of each possible disorder, and how the symptoms, signs and investigations alter those probabilities to allow a conclusion to be reached about the most likely diagnosis. Evidence-Based Diagnosis in Primary Care also explains the principles of evidence-based diagnosis – with special emphasis on the issues raised by attempting an evidence-based approach in primary care – and clearly demonstrates the power, and the difficulties, of an evidence-based approach. Many chapters also feature ‘red flags’ – elements of the history or examination that should alert the practitioner to the possibility of serious disease, which is vital for general practice.

Getting the right diagnosis is a key aspect of health care - it provides an explanation of a patient's health problem and informs subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors-inaccurate or delayed diagnoses-persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors may cause harm to patients by preventing or delaying appropriate treatment, providing unnecessary or harmful treatment, or resulting in psychological or financial repercussions. The committee concluded that improving the diagnostic process is not only possible, but also represents a moral, professional, and public health imperative. Improving Diagnosis in Health Care, a continuation of the landmark Institute of Medicine reports To Err Is Human (2000) and Crossing the Quality Chasm (2001), finds that diagnosis-and, in particular, the occurrence of diagnostic errorsâ€"has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety.

Praise for the First Edition: “Developing a comprehensive differential diagnosis for a specific complaint is a daunting task even for experienced advanced practice nurses. This user-friendly clinical guide provides a strategy and standard format for working through this complex task. It is a wonderful tool for both students and new advanced practice nurses...” -- 5 stars, Doody’s This easy-access clinical guide to over 70 commonly seen symptoms, written for advanced practice provider (APP) students and new practitioners, describes a step-by-step process for obtaining a reliable patient history, choosing the appropriate physical exam, and using the patient history and physical exam findings to form a differential diagnosis. The second edition continues to include the case study approach, and is updated to incorporate 22 new symptoms along with contributions by a new editor, who is a leader in holistic health. The guide is distinguished by several unique features including focused patient history questions and responses, Physical Exam Findings, a Differential Diagnosis Table (clearly comparing potential diagnostic choices based on symptoms), a Diagnostic Examination table (including estimated costs and codes), and a Case Study Summary highlighting the critical thinking process. Symptoms are presented alphabetically in a systematic, unfolding case study approach and include chief complaint, presenting history, past history, and explicit methodology for determining correct diagnosis. Key Features: Describes over 70 (22 new to the second edition) commonly presented symptoms with unfolding case scenarios Offers a step-by-step approach to building clinical decision-making skills Provides quick access to differential diagnosis, requisite diagnostic tests, and clinical-decision making Guides APP students and novice practitioners in conducting a problem-focused history and examination Includes unique Differential Diagnosis tables and Diagnostic Examinations tables that help clarify strategies for diagnostic decision making

Diagnosis and Treatment in Internal Medicine equips trainee doctors with the essential skills and core knowledge to establish a diagnosis reliably and quickly, before outlining the management of the clinical condition diagnosed. Organised into three sections, the first provides a vital overview, whilst the second focuses on common presentations and diagnoses. Uniquely, this new book shows readers how to turn symptoms into a list of diagnoses ordered by probability - a differential diagnosis. Experienced consultants who teach trainees every day demonstrate how to derive an ordered differential diagnosis, how to narrow this down to a single diagnosis and if not, how to live with diagnostic uncertainty. The final section provides a comprehensive account of the management of system-based syndromes and diseases. Highly-structured chapters emphasize how common conditions present, how to approach a diagnosis, and how to estimate prognosis, treatment and its effectiveness. An onus is placed on the development of crucial diagnostic skills and the ability to devise evidence-based management plans quickly and accurately, making this an ideal text for core medical trainees.

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease. - Includes new material on mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more - Provides insights on the value of the molecular test in comparison to traditional methods, which include speed, precision, sensitivity and clinical impacts for the patient - Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis and classification in the clinical workup of a patient - Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for the prognostication of disease