For two hundred years a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass. What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world. In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future. Through exclusive interviews and original archival research, Max explains this story’s connection to human greed and ambition–from the Prussian chemist Justus von Liebig, who made cattle meatier by feeding them the flesh of other cows, to New Guinean natives whose custom of eating the brains of the dead nearly wiped them out. The biologists who have investigated these afflictions are just as extraordinary–for example, Daniel Carleton Gajdusek, a self-described “pedagogic pedophiliac pediatrician” who cracked kuru and won the Nobel Prize, and another Nobel winner, Stanley Prusiner, a driven, feared self-promoter who identified the key protein that revolutionized prion study. With remarkable precision, grace, and sympathy, Max–who himself suffers from an inherited neurological illness–explores maladies that have tormented humanity for centuries and gives reason to hope that someday cures will be found. And he eloquently demonstrates that in our relationship to nature and these ailments, we have been our own worst enemy.

"When Bear can't sleep, he goes on an adventure and discovers the wonders of New York City--a parade, Central Park, hot dogs, and more! But when he finally gets tired and looks for a place to rest, he learns why it's called the city that never sleeps"--Dust jacket flap.

Perfect for bedtime, Arlo The Lion Who Couldn't Sleep is a beautifully illustrated story with a gentle mindfulness message from award-wining author-illustrator Catherine Rayner. Shortlisted for the Kate Greenaway Medal, it's especially helpful for little ones who have trouble going to sleep. Arlo the lion is exhausted. He just can't drop off, no matter what he tries. It's either too hot, or too cold; too loud or too quiet. But then he meets Owl. She can sleep through the day, which isn't easy when most other animals are awake! Will Arlo ever get any rest? Perhaps his new friend has some special tricks she can teach him to help him sleep . . .

A wildly original and hilarious debut novel about the typical high school experience: the homework, the awkwardness, and the mutant creatures from another galaxy. When Darren Bennett meets Eric Lederer, there's an instant connection. They share a love of drawing, the bottom rung on the cruel high school social ladder and a pathological fear of girls. Then Eric reveals a secret: He doesn’t sleep. Ever. When word leaks out about Eric's condition, he and Darren find themselves on the run. Is it the government trying to tap into Eric’s mind, or something far darker? It could be that not sleeping is only part of what Eric's capable of, and the truth is both better and worse than they could ever imagine.

Whenever Ava can't sleep, she counts sheep. But Ava takes so long to fall asleep, it's the sheep that are growing tired-until finally, they quit! When the sheep promise to find a replacement that Ava can count on, chaos ensues as chickens, cows, pigs, hippos, and more try their hand at jumping over Ava's fence. Finding the perfectly peaceful replacement for sheep might not be so easy after all. With irresistibly adorable art, this delightful take on a familiar sleep tactic is sure to become a bedtime favorite.

Lara and her family adopt an adorable puppy that Lara had found and names him, Jet. But Jet howls all night long! What can Lara do to help her puppy sleep? When Lara finds a homeless puppy in an alley, she knows she has to help. She brings him back to her house and names him Jet, and he seems delighted with his new home. There's just one problem. When night falls, the world becomes a scary place for Jet and his howling keeps the entire family awake. Lara is desperate to help the puppy sleep--but what can she do?

The Instant New York Times bestseller A TODAY Show Read with Jenna Book Club Pick A captivating debut novel about the tangled fates of two best friends and daughters of the Italian mafia, and a coming-of-age story of twentieth-century Brooklyn itself. Two daughters. Two families. One inescapable fate. Sofia Colicchio is a free spirit, loud and untamed. Antonia Russo is thoughtful, ever observing the world around her. Best friends since birth, they live in the shadow of their fathers’ unspoken community: the Family. Sunday dinners gather them each week to feast, discuss business, and renew the intoxicating bond borne of blood and love. But the disappearance of Antonia’s father drives a whisper-thin wedge between the girls as they grow into women, wives, mothers, and leaders. Their hearts expand in tandem with Red Hook and Brooklyn around them, as they push against the boundaries of society’s expectations and fight to preserve their complex but life-sustaining friendship. One fateful night their loyalty to each other and the Family will be tested. Only one of them can pull the trigger before it’s too late.

After hunting all night, Harold the Owl lands on a branch ready for a long snooze. But just as he starts to fall asleep, the birds begin chirping. And then the gardener starts his leaf blower. Harold doesn't want to stay awake all day. He needs to sleep, so he'll be ready for nighttime... Lesley Leadbetter strongly supports the preservation of wildlife, and has written this story to help children learn to love and appreciate our native birds.

A disturbing literary dystopian science fiction debut set in a near-future Vancouver during a deadly insomnia pandemic for fans of The Leftovers Dawn breaks over Vancouver and no one in the world has slept the night before, or almost no one. A few people, perhaps one in ten thousand, can still sleep, and they’ve all shared the same golden dream. After six days of absolute sleep deprivation, psychosis will set in. After four weeks, the body will die. In the interim, panic ensues and a bizarre new world arises in which those previously on the fringes of society take the lead. Paul, a writer, continues to sleep while his partner Tanya disintegrates before his eyes, and the new world swallows the old one whole.

The acclaimed author explores the hidden crises of Gen X women in this “engaging hybrid of first-person confession, reportage [and] pop culture analysis” (The New Republic). Ada Calhoun was married with children and a good career—and yet she was miserable. She thought she had no right to complain until she realized how many other Generation X women felt the same way. What could be behind this troubling trend? To find out, Calhoun delved into housing costs, HR trends, credit card debt averages, and divorce data. At every turn, she saw that Gen X women were facing new problems as they entered middle age—problems that were being largely overlooked. Calhoun spoke with women across America who were part of the generation raised to “have it all.” She found that most were exhausted, terrified about money, under-employed, and overwhelmed. And instead of being heard, they were being told to lean in, take “me-time,” or make a chore chart to get their lives and homes in order. In Why We Can’t Sleep, Calhoun opens up the cultural and political contexts of Gen X’s predicament. She offers practical advice on how to ourselves out of the abyss—and keep the next generation of women from falling in. The result is reassuring, empowering, and essential reading for all middle-aged women, and anyone who hopes to understand them.