Do antidepressants work? Of course -- everyone knows it. Like his colleagues, Irving Kirsch, a researcher and clinical psychologist, for years referred patients to psychiatrists to have their depression treated with drugs before deciding to investigate for himself just how effective the drugs actually were. Over the course of the past fifteen years, however, Kirsch's research -- a thorough analysis of decades of Food and Drug Administration data -- has demonstrated that what everyone knew about antidepressants was wrong. Instead of treating depression with drugs, we've been treating it with suggestion. The Emperor's New Drugs makes an overwhelming case that what had seemed a cornerstone of psychiatric treatment is little more than a faulty consensus. But Kirsch does more than just criticize: he offers a path society can follow so that we stop popping pills and start proper treatment for depression.

Due to the recent explosion of placebo research at many levels the Editors believe that a volume on Placebo would be a good addition to the Handbook of Experimental Pharmacology series. In particular, this volume will be built up on a meeting on Placebo which will be held in Tuebingen (Germany) in January 2013, and where the most prominent researchers in this field will present and exchange their ideas. The authors who will be invited to write chapters for this volume will be the very same speakers at this meeting, thus guaranteeing high standard and excellence in the topic that will be treated. The approach of the book is mainly pharmacological, including basic research and clinical trials, and the contents range from different medical conditions and systems, such as pain and the immune system, to different experimental approaches, like in vivo receptor binding and pharmacological/behavioral conditioning. Overall, the volume will give an idea of modern placebo research, of timely concepts in both experimental and clinical pharmacology, as well as of modern methods and tools in neuroscience.

"Graves' answers could revise the ways in which humans interact with one another."--"Choice." "A fine start for thinking about race at the dawn of the millennium."--"American Scientist."

Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

A physician offers an impassioned and meticulously researched exposé of the alternative medicine industry, separating the sense from the nonsense. A half century ago, acupuncture, homeopathy, naturopathy, Chinese herbs, Christian exorcisms, dietary supplements, chiropractic manipulations, and ayurvedic remedies were considered on the fringe of medicine. Now these practices—known variably as alternative, complementary, holistic, or integrative medicine—have become mainstream, used by half of all Americans today to treat a variety of conditions, from excess weight to cancer. But alternative medicine is an unregulated industry under no legal obligation to prove its claims or admit its risks, and many popular alternative therapies are ineffective, expensive, or even deadly. In Do You Believe in Magic?, health advocate Dr. Offit debunks the treatments that don’t work and tells us why, and takes on the media celebrities who promote alternative medicine. Using dramatic real-life stories, he separates the sense from the nonsense, explaining why any therapy—alternative or traditional—should be scrutinized. As Dr. Offit explains, some popular therapies are remarkably helpful due to the placebo response, but “there’s no such thing as alternative medicine. There’s only medicine that works and medicine that doesn’t.”

Kirsch, a researcher and clinical psychologist, for years referred patients to psychiatrists to have their depression treated with drugs before deciding to investigate for himself just how effective the drugs actually were. His research has demonstrated that what everyone knew about antidepressants was wrong. Instead of treating depression with drugs, we've been treating it with suggestion.

We know about Hippocrates, the Father of Medicine. But we owe nearly as much to Galen, a physician born in 129 A.D. at the height of the Roman Empire. Galen's acute diagnoses of patients, botanical wisdom, and studies of physiology were recorded in numerous books, handed down through the Middle Ages and Renaissance. Not least, Galen passed on the medical tradition of respect for life. In this fascinating biography for young people, Jeanne Bendick brings Galen's Roman world to life with the clarity, humor, and outstanding content we enjoyed in Archimedes and the Door to Science. An excellent addition to the home, school and to libraries. Illustrated by the Author.

Emperors in the Jungle is an exposé of key episodes in the military involvement of the United States in Panama. Investigative journalism at its best, this book reveals how U.S. ideas about taming tropical jungles and people, combined with commercial and military objectives, shaped more than a century of intervention and environmental engineering in a small, strategically located nation. Whether uncovering the U.S. Army’s decades-long program of chemical weapons tests in Panama or recounting the invasion in December 1989 which was the U.S. military’s twentieth intervention in Panama since 1856, John Lindsay-Poland vividly portrays the extent and costs of U.S. involvement. Analyzing new evidence gathered through interviews, archival research, and Freedom of Information Act requests, Lindsay-Poland discloses the hidden history of U.S.–Panama relations, including the human and environmental toll of the massive canal building project from 1904 to 1914. In stunning detail he describes secret chemical weapons tests—of toxins including nerve agent and Agent Orange—as well as plans developed in the 1960s to use nuclear blasts to create a second canal in Panama. He chronicles sustained efforts by Panamanians and international environmental groups to hold the United States responsible for the disposal of the tens of thousands of explosives it left undetonated on the land it turned over to Panama in 1999. In the context of a relationship increasingly driven by the U.S. antidrug campaigns, Lindsay-Poland reports on the myriad issues that surrounded Panama’s takeover of the canal in accordance with the 1977 Panama Canal Treaty, and he assesses the future prospects for the Panamanian people, land, and canal area. Bringing to light historical legacies unknown to most U.S. citizens or even to many Panamanians, Emperors in the Jungle is a major contribution toward a new, more open relationship between Panama and the United States.

Oversized volume containing everything known about the usefulness of the cannabis plant. Completely revised, updated and expanded for more ways that hemp can really save the world.

NEW YORK TIMES BESTSELLER • A NEW YORK TIMES NOTABLE BOOK OF THE YEAR • A grand, devastating portrait of three generations of the Sackler family, famed for their philanthropy, whose fortune was built by Valium and whose reputation was destroyed by OxyContin. From the prize-winning and bestselling author of Say Nothing. "A real-life version of the HBO series Succession with a lethal sting in its tail…a masterful work of narrative reportage.” – Laura Miller, Slate The history of the Sackler dynasty is rife with drama—baroque personal lives; bitter disputes over estates; fistfights in boardrooms; glittering art collections; Machiavellian courtroom maneuvers; and the calculated use of money to burnish reputations and crush the less powerful. The Sackler name has adorned the walls of many storied institutions—Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, but the source of the family fortune was vague—until it emerged that the Sacklers were responsible for making and marketing a blockbuster painkiller that was the catalyst for the opioid crisis. Empire of Pain is the saga of three generations of a single family and the mark they would leave on the world, a tale that moves from the bustling streets of early twentieth-century Brooklyn to the seaside palaces of Greenwich, Connecticut, and Cap d’Antibes to the corridors of power in Washington, D.C. It follows the family’s early success with Valium to the much more potent OxyContin, marketed with a ruthless technique of co-opting doctors, influencing the FDA, downplaying the drug’s addictiveness. Empire of Pain chronicles the multiple investigations of the Sacklers and their company, and the scorched-earth legal tactics that the family has used to evade accountability. A masterpiece of narrative reporting, Empire of Pain is a ferociously compelling portrait of America’s second Gilded Age, a study of impunity among the super-elite and a relentless investigation of the naked greed that built one of the world’s great fortunes.