This book covers the latest information on the anatomic features, underlying physiologic mechanisms, and treatments for diseases of the heart. Key chapters address animal models for cardiac research, cardiac mapping systems, heart-valve disease and genomics-based tools and technology. Once again, a companion of supplementary videos offer unique insights into the working heart that enhance the understanding of key points within the text. Comprehensive and state-of-the art, the Handbook of Cardiac Anatomy, Physiology and Devices, Third Edition provides clinicians and biomedical engineers alike with the authoritative information and background they need to work on and implement tomorrow’s generation of life-saving cardiac devices.

Sunao Tawara's epoch-making work on the excitation conduction system of the mammalian heart paved the way for the advancement of modern cardiology in the 20th century. Even today, more than 90 years after the publication of the German monograph “Das Reizleitungssystem des Säugetierherzen”, his precise account of the conduction system from the atrioventricular node through the His-Purkinje system to the ordinary ventricular muscle fibers retains all of its original actuality.This English edition of Tawara's monograph will serve as an invaluable reference for both basic and clinical cardiological research in the years ahead.

The pacemaking and conduction system (PCS) is vital for generating and synchronizing the heart beat. Dysfunction of this system can be a direct cause of cardiac conduction disturbance, arrhythmias and sudden cardiac death. A wealth of information has been collected over many years on the unique histological, morphological and phenotypic characteristics of specialized cardiac tissues. The cellular and molecular mechanisms that govern development of the PCS are now starting to be understood. This book draws together contributions from an international and interdisciplinary group of experts working on both basic and clinical aspects of cardiac development. It features reviews of the structure and function of the developing PCS, discussion of the molecular and cellular mechanisms regulating embryological development of this system and studies on the fundamental basis of PCS pathology. The book also considers how novel therapeutic interventions based on understanding of the developmental biology of cardiac pacemaking and conduction tissues might ultimately impact on clinical medicine.

Guide to Canine and Feline Electrocardiography offers a comprehensive and readable guide to the diagnosis and treatment of abnormal heart rhythms in cats and dogs. Covers all aspects of electrocardiography, from basics to advanced concepts of interest to specialists Explains how to obtain high-quality electrocardiograms Offers expert insight and guidance on the diagnosis and treatment of simple and complex arrhythmias alike Features numerous case examples, with electrocardiograms and Holter monitor recordings Shows the characteristics of normal and abnormal heart rhythms in dogs and cats Includes access to a website with self-assessment questions and the appendices and figures from the book

This monograph had its genesis in a workshop on the specific conduction held in the spring of 1975. The meeting was organized to discuss present knowledge on structure and function of the cardiac specialized tissues with emphasis on their clinical implications. Since much new information was presented, the participants agreed to prepare manuscripts and make their material available for publication. This has resulted in a book in which the cardiac specialized tissues are discussed by different specialists: the electron-microscopist, anatomist, pathologist, physiologist, physicist and clinician. Apart from their interest in the cardiac conduction system the participants shared the opinion that their contribu tion should be relevant to the understanding and treatment of patients with cardiac arrhythmias. The book should be useful for the clinician, the morphologist and the physio logist. The workshop took place at the University Department of Cardiology, Wilhelmina Gasthuis, Amsterdam, The Netherlands. This is the home ground of one of the most outstanding electro cardiologists of our time, Dr. Dirk Durrer. By pairing genius and originality with endless fund of energy and dogged persistence he made several important contributions to modern cardiac electrophysiology. In recent years he created a cardio logical institute where workers from various disciplines cooperate in the study and treat ment of cardiac disease. Several of his pupils participated in the workshop and contributed to this volume. In appreciation and thankfulness we want to dedicate this book to Dr. Dirk Durrer.

One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.

Fully revised and updated, the fourth edition of Cardiac Pacingand ICDs continues to be an accessible and practical clinicalreference for residents, fellows, surgeons, nurses, PAs, andtechnicians. The chapters are organized in the sequence of the evaluation ofan actual patient, making it an effective practical guide. Revisedchapters and updated artwork and tables plus a new chapter oncardiac resynchronization make the new edition an invaluableclinical resource. Features: · New chapter on Cardiac Resynchronization Therapy · Updated and better quality figures and tables · Updated content based on ACC/AHA/NASPE guidelines · Updated indications for ICD placement · Updated information on ICD and pacemakertroubleshooting

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. - Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research - Gives concise explanations of key issues and background reading suggestions - Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, pharmaceutical, and medical personnel is interested in studying various aspects of arrhythmias at a basic, translational, and applied level, both in industry (ie Biotech, Pharmaceutical and device), and in academia. Not only has our overall understanding of molecular bases of disease dramatically increased, but so has the number of available and emerging molecular, pharmacological or device treatment based therapies. This practical, state-of-the art handbook will summarize and review key research methods and protocols, their advantages and pitfalls, with a focus on practical implementation, and collaborative cross-functional research. The volume will include visual and easy-to-use graphics, bulleted summaries, boxed summary paragraphs, links to reference websites, equipment manufacturers where appropriate, photographs of typical experimental setups and so forth, to keep this book very focused on practical methods and implementation, and yet, provide enough theory that the principles are clearly understood and can be easily applied.