The X-H1 in plain English! Written for Fujifilm's outstanding X-H1 camera, this is This is EVERYTHING X-H1 explained in easy to understand language! It is the Manual on Steroids and much more... In it, I assume you are a photographer, so I don't dive in to the basics of photography (except in an Appendix). Everything comes with clear tutorials and examples. So if you're uncertain about anything your X-H1 does, grab this book! It's packed with clear tutorials and examples, with over 900 tips, tricks, and tweaks to help you master photography with your X-H1.

The best help in the world on the X-T4! Written for Fujifilm's outstanding X-T4 hybrid camera, this is EVERYTHING X-T4 explained in easy to understand language! It is the Manual on Steroids and much more... In it, I assume you are a photographer, so I don't dive in to the basics of photography (except in an Appendix). Everything comes with clear tutorials and examples. So if you're uncertain about anything your X-T4 does, grab this book! It's packed with clear tutorials and examples, with over 900 tips, tricks, and tweaks to help you master photography and videography with your X-T4. This 732-page full-color book: * Is packed with over 900 tips and tricks to help you master photography with an X-T4. * Covers every mode, menu, button, function, switch and socket. * All about the EF-X500 and wireless flash. Includes third-party flashes and the new Fujifilm EF-60 flash and trigger. * Covers Lighting - even Manual flash! * Multiple chapters covering all things video. Plus * Discover all my camera settings - including why I do it that way. * Covers every essential of shooting - like: ISO, Focus, WB, Metering, flash modes - and the more esoteric ones too. * Understand how and why to customize buttons and menus. * Explains why all glass (Fuji lenses) are not born equal. * Read a great treatise to help you master the ins and outs of RAW, and RAW specific shooting. * Included is a 22 page Condensed Guide to the Basics of modern digital photography. PLUS, PLUS, PLUS: Also included is a full list of all my settings, with explanations for why things are set up that way. Plus, in the final Release, there will be author bonuses. Ed. 1 of my Fujifilm Flash book, an XLS spreadsheet with all the camera settings with explanations, and a Phone Companion with all the settings and a summary of each. A $19.95 value right there.

Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

A beacon of creativity with boundless energy, Chase Jarvis is well known as a visionary photographer, director, and social artist. In The Best Camera Is The One That’s With You, Chase reimagines, examines, and redefines the intersection of art and popular culture through images shot with his iPhone. The pictures in the book, all taken with Chase’s iPhone, make up a visual notebook—a photographic journal—from the past year of his life. The book is full of visually-rich iPhone photos and peppered with inspiring anecdotes. Two megapixels at a time, these images have been gathered and bound into a book that represents a stake in the ground. With it, Chase underscores the idea that an image can come from any camera, even a mobile phone. As Chase writes, “Inherently, we all know that an image isn’t measured by its resolution, dynamic range, or anything technical. It’s measured by the simple—sometimes profound, other times absurd or humorous or whimsical—effect that it can have upon us. If you can see it, it can move you.” This book is geared to inspire everyone, regardless of their level of photography knowledge, that you can capture moments and share them with our friends, families, loved ones, or the world at the press of a button. Readers of The Best Camera Is The One That’s With You will also enjoy the iPhone application Chase Jarvis created in conjunction with this book, appropriately named Best Camera. Best Camera has a unique set of filters and effects that can be applied at the touch of a button. Stack them. Mix them. Remix them. Best Camera also allows you to share directly to a host of social marketing sites via www.thebestcamera.com, a new online community that allows you to contribution to a living, breathing gallery of the best iPhone photography from around the globe. Together, the book, app, and website, represent a first-of-its-kind ecosystem dedicated to encouraging creativity through picture taking with the camera that you already have. The Best Camera Is The One That’s With You—shoot!

The tenth edition of The Manual of Photography is an indispensable textbook for anyone who is serious about photography. It is ideal if you want to gain insight into the underlying scientific principles of photography and digital imaging, whether you are a professional photographer, lab technician, researcher or student in the field, or simply an enthusiastic amateur. This comprehensive guide takes you from capture to output in both digital and film media, with sections on lens use, darkroom techniques, digital cameras and scanners, image editing techniques and processes, workflow, digital file formats and image archiving. This iconic text was first published in 1890 and has aided many thousands of photographers in developing their own techniques and understanding of the medium. Now in full colour, The Manual of Photography still retains its clear, reader-friendly style and is filled with images and illustrations demonstrating the key principles. Not only giving you the skills and know-how to take stunning photographs, but will also allowing you to fully understand the science behind the creation of great images.

This book introduces piezoelectric microelectromechanical (pMEMS) resonators to a broad audience by reviewing design techniques including use of finite element modeling, testing and qualification of resonators, and fabrication and large scale manufacturing techniques to help inspire future research and entrepreneurial activities in pMEMS. The authors discuss the most exciting developments in the area of materials and devices for the making of piezoelectric MEMS resonators, and offer direct examples of the technical challenges that need to be overcome in order to commercialize these types of devices. Some of the topics covered include: Widely-used piezoelectric materials, as well as materials in which there is emerging interest Principle of operation and design approaches for the making of flexural, contour-mode, thickness-mode, and shear-mode piezoelectric resonators, and examples of practical implementation of these devices Large scale manufacturing approaches, with a focus on the practical aspects associated with testing and qualification Examples of commercialization paths for piezoelectric MEMS resonators in the timing and the filter markets ...and more! The authors present industry and academic perspectives, making this book ideal for engineers, graduate students, and researchers.

The psychology of eating is regulated by neural mechanisms. When not well controlled, eating may result in disorders and health hazards such as obesity, type 2 diabetes mellitus, and vascular diseases. Lifestyles and cultures influence eating habits, thus there are differences in the prevalence of health problems depending upon living environments. This book examines the psychology and the pathophysiological outcomes of eating. Chapters address such topics as the influence of lifestyle, circadian rhythm, sleep, and fragrant odors on appetite and weight regulation; the impact of glucose, sucrose, lactate, and ketone bodies on the brain; the consequences of glycation stress on the skeletal muscle; and much more.

This book constitutes the refereed proceedings of the Second International Workshop on Machine Learning for Medical Reconstruction, MLMIR 2019, held in conjunction with MICCAI 2019, in Shenzhen, China, in October 2019. The 24 full papers presented were carefully reviewed and selected from 32 submissions. The papers are organized in the following topical sections: deep learning for magnetic resonance imaging; deep learning for computed tomography; and deep learning for general image reconstruction.

This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and cutting-edge, G-Quadruplex DNA: Methods and Protocols is a valuable resource for both novice and experienced researchers who work in biophysics, structural biology, computational biology, biochemistry, and molecular and cell biology, and who want to learn more about the potential roles and effects of G-quadruplex in these fields.

Recent biochemical studies indicate that calorie restriction (CR) is a widely accepted method for anti-aging intervention. CR and intermittent fasting (IF), which involves reduced calories but proper nutritional intake during specific periods, are interventions that can consistently promote health benefits, delay biological aging, and extend both average and maximal lifespan. Furthermore, CR can modulate age-related diseases such as Alzheimer’s disease, atherosclerosis, diabetes, obesity, cancer, and others. Advances in omics technologies have provided a technical breakthrough that enabled the investigation of DNA, RNA, proteins, and other cellular molecules and their comprehensive interactions in a biological context. Nowadays, it is possible to analyze and integrate biological processes that occur in aging systems at the molecular level using state-of-the-art techniques such as next-generation sequencing (NGS), proteomics, lipidomics, metabolomics, and epigenomics. Omics technology and systems gerontology provide predictive information on CR effects, molecular mechanisms, and pathways underlying the anti-aging actions of CR and IF. This Special Issue, “The effects of calorie restriction and intermittent fasting on health and disease”, focuses on the effects of calorie restriction and intermittent fasting on age-related inflammation, autophagy, metabolism, longevity, mitochondrial function, and age-related diseases.