In this masterful account, a historian of science surveys the molecular biology revolution, its origin and continuing impact. Since the 1930s, a molecular vision has been transforming biology. Michel Morange provides an incisive and overarching history of this transformation, from the early attempts to explain organisms by the structure of their chemical components, to the birth and consolidation of genetics, to the latest technologies and discoveries enabled by the new science of life. Morange revisits A History of Molecular Biology and offers new insights from the past twenty years into his analysis. The Black Box of Biology shows that what led to the incredible transformation of biology was not a simple accumulation of new results, but the molecularization of a large part of biology. In fact, Morange argues, the greatest biological achievements of the past few decades should still be understood within the molecular paradigm. What has happened is not the displacement of molecular biology by other techniques and avenues of research, but rather the fusion of molecular principles and concepts with those of other disciplines, including genetics, physics, structural chemistry, and computational biology. This has produced decisive changes, including the discoveries of regulatory RNAs, the development of massive scientific programs such as human genome sequencing, and the emergence of synthetic biology, systems biology, and epigenetics. Original, persuasive, and breathtaking in its scope, The Black Box of Biology sets a new standard for the history of the ongoing molecular revolution.

Every day it seems the media focus on yet another new development in biology--gene therapy, the human genome project, the creation of new varieties of animals and plants through genetic engineering. These possibilities have all emanated from molecular biology. A History of Molecular Biology is a complete but compact account for a general readership of the history of this revolution. Michel Morange, himself a molecular biologist, takes us from the turn-of-the-century convergence of molecular biology's two progenitors, genetics and biochemistry, to the perfection of gene splicing and cloning techniques in the 1980s. Drawing on the important work of American, English, and French historians of science, Morange describes the major discoveries--the double helix, messenger RNA, oncogenes, DNA polymerase--but also explains how and why these breakthroughs took place. The book is enlivened by mini-biographies of the founders of molecular biology: Delbrück, Watson and Crick, Monod and Jacob, Nirenberg. This ambitious history covers the story of the transformation of biology over the last one hundred years; the transformation of disciplines: biochemistry, genetics, embryology, and evolutionary biology; and, finally, the emergence of the biotechnology industry. An important contribution to the history of science, A History of Molecular Biology will also be valued by general readers for its clear explanations of the theory and practice of molecular biology today. Molecular biologists themselves will find Morange's historical perspective critical to an understanding of what is at stake in current biological research.

Behe argues that the complexity of cellular biochemistry argues against Darwin's gradual evolution.

Bricks and boxes -- Between Scylla and Charybdis -- Lessons from the history of science -- Placeholders -- Black-boxing 101 -- History of science 'black-boxing style' -- Diet mechanistic philosophy -- Emergence reframed -- The fuel of scientific progress -- Sailing through the strait.

A comprehensive history of the biological sciences from antiquity to the modern era This book presents a global history of the biological sciences from ancient times to today, providing needed perspective on the development of biological thought while shedding light on the field's upheavals and key breakthroughs through the ages. Michel Morange brings to life the dynamic interplay of science, society, and biology’s many subdisciplines, enabling readers to better appreciate the interdisciplinary exchanges that have shaped the field over the centuries. Each chapter of this incisive book focuses on a specific period in the history of biology, describing the major transformations that occurred, the enduring scientific concerns behind these changes, and the implications of yesterday's science for today's. Morange covers everything from the first cell theory to the origins of the concept of ecosystems, and offers perspectives on areas that are often neglected by historians of biology, such as ecology, ethology, and plant biology. Along the way, he highlights the contributions of technology, the important role of hypothesis and experimentation, and the cultural contexts in which some of the most breathtaking discoveries in biology were made. Unrivaled in scope and written by a world-renowned historian of science, A History of Biology is an ideal introduction for students and experts alike, and essential reading for anyone seeking to understand the present state of biological knowledge.

Every day, corporations are connecting the dots about our personal behavior—silently scrutinizing clues left behind by our work habits and Internet use. The data compiled and portraits created are incredibly detailed, to the point of being invasive. But who connects the dots about what firms are doing with this information? The Black Box Society argues that we all need to be able to do so—and to set limits on how big data affects our lives. Hidden algorithms can make (or ruin) reputations, decide the destiny of entrepreneurs, or even devastate an entire economy. Shrouded in secrecy and complexity, decisions at major Silicon Valley and Wall Street firms were long assumed to be neutral and technical. But leaks, whistleblowers, and legal disputes have shed new light on automated judgment. Self-serving and reckless behavior is surprisingly common, and easy to hide in code protected by legal and real secrecy. Even after billions of dollars of fines have been levied, underfunded regulators may have only scratched the surface of this troubling behavior. Frank Pasquale exposes how powerful interests abuse secrecy for profit and explains ways to rein them in. Demanding transparency is only the first step. An intelligible society would assure that key decisions of its most important firms are fair, nondiscriminatory, and open to criticism. Silicon Valley and Wall Street need to accept as much accountability as they impose on others.

Nobody wants to fail. But in highly complex organizations, success can happen only when we confront our mistakes, learn from our own version of a black box, and create a climate where it’s safe to fail. We all have to endure failure from time to time, whether it’s underperforming at a job interview, flunking an exam, or losing a pickup basketball game. But for people working in safety-critical industries, getting it wrong can have deadly consequences. Consider the shocking fact that preventable medical error is the third-biggest killer in the United States, causing more than 400,000 deaths every year. More people die from mistakes made by doctors and hospitals than from traffic accidents. And most of those mistakes are never made public, because of malpractice settlements with nondisclosure clauses. For a dramatically different approach to failure, look at aviation. Every passenger aircraft in the world is equipped with an almost indestructible black box. Whenever there’s any sort of mishap, major or minor, the box is opened, the data is analyzed, and experts figure out exactly what went wrong. Then the facts are published and procedures are changed, so that the same mistakes won’t happen again. By applying this method in recent decades, the industry has created an astonishingly good safety record. Few of us put lives at risk in our daily work as surgeons and pilots do, but we all have a strong interest in avoiding predictable and preventable errors. So why don’t we all embrace the aviation approach to failure rather than the health-care approach? As Matthew Syed shows in this eye-opening book, the answer is rooted in human psychology and organizational culture. Syed argues that the most important determinant of success in any field is an acknowledgment of failure and a willingness to engage with it. Yet most of us are stuck in a relationship with failure that impedes progress, halts innovation, and damages our careers and personal lives. We rarely acknowledge or learn from failure—even though we often claim the opposite. We think we have 20/20 hindsight, but our vision is usually fuzzy. Syed draws on a wide range of sources—from anthropology and psychology to history and complexity theory—to explore the subtle but predictable patterns of human error and our defensive responses to error. He also shares fascinating stories of individuals and organizations that have successfully embraced a black box approach to improvement, such as David Beckham, the Mercedes F1 team, and Dropbox.

In Gene Sharing and Evolution Piatigorsky explores the generality and implications of gene sharing throughout evolution and argues that most if not all proteins perform a variety of functions in the same and in different species, and that this is a fundamental necessity for evolution.

The universality of musical tones has long fascinated philosophers, scientists, musicians, and ordinary listeners. Why do human beings worldwide find some tone combinations consonant and others dissonant? Why do we make music using only a small number of scales out of the billions that are possible? Why do differently organized scales elicit different emotions? Why are there so few notes in scales? In Music as Biology, Dale Purves argues that biology offers answers to these and other questions on which conventional music theory is silent. When people and animals vocalize, they generate tonal sounds—periodic pressure changes at the ear which, when combined, can be heard as melodies and harmonies. Human beings have evolved a sense of tonality, Purves explains, because of the behavioral advantages that arise from recognizing and attending to human voices. The result is subjective responses to tone combinations that are best understood in terms of their contribution to biological success over evolutionary and individual history. Purves summarizes evidence that the intervals defining Western and other scales are those with the greatest collective similarity to the human voice; that major and minor scales are heard as happy or sad because they mimic the subdued and excited speech of these emotional states; and that the character of a culture’s speech influences the tonal palette of its traditional music. Rethinking music theory in biological terms offers a new approach to centuries-long debates about the organization and impact of music.

Basic concepts of molecular biology. Strings, graphs, and algorithms. Sequence comparasion and database search. Fragment assembly of DNA. Physical mapping of DNA. Phylogenetic trees. Genome rearrangements. Molecular structure prediction. epilogue: computing with DNA. Answers to selected exercises. References. index.