An authoritative, extensively illustrated clinician's textbook, The Biology of the Skin is written expressly for practitioners and residents in dermatology, plastic surgery, and otolaryngology. Essentially an expansion of the editors' and contributing authors' popular "Structure and Function" course given annually at the meetings of the American Academy of Dermatology, the book teaches skin biology in the context of practical clinical settings. This book covers the basic biology of the skin, how the skin functions, effects of the environment, the molecules that direct cutaneous function, genetic influences, and methods in cutaneous research. The Biology of the Skin provides a selective review of all biologic processes involving the skin and will foster an appreciation of how the skin works based on our knowledge of the basic science of skin structure and function in the 21st century.

Molecular Biology of the Skin: The Keratinocyte comprehensively reviews the major aspects of keratinocyte and epidermal differentiation, physiology, and pathology, primarily focusing on the molecular aspects. This exciting new resource discusses keratin genes, retinoic acid, and the use of transgenic animals in the study of dermatological pathology. The volume also highlights areas of genetic disease, new animal models to help in understanding dermatological disorders, and gene therapy using skin as a target. W.W. Franke, a pioneer in the study of the molecular biology of keratins, has written the foreword for the book.Molecular Biology of the Skin: The Keratinocyte is intended for use by dermatologists and basic researchers in cell and developmental biology. It will also be valuable for surgeons and other clinicians as well as researchers in gene therapy, virology, and pharmacology.* * Reviews keratinocyte (and epidermal) differentiation. physiology, and pathology, focusing on the molecular aspects* -Discusses keratin genes, retinoic acid, and the use of transgenic animals in the study of dermatalogical pathology* -Highlights genetic disease, new animal models, and gene therapy

Living Color is the first book to investigate the social history of skin color from prehistory to the present, showing how our body’s most visible trait influences our social interactions in profound and complex ways. In a fascinating and wide-ranging discussion, Nina G. Jablonski begins with the biology and evolution of skin pigmentation, explaining how skin color changed as humans moved around the globe. She explores the relationship between melanin pigment and sunlight, and examines the consequences of rapid migrations, vacations, and other lifestyle choices that can create mismatches between our skin color and our environment. Richly illustrated, this book explains why skin color has come to be a biological trait with great social meaning— a product of evolution perceived by culture. It considers how we form impressions of others, how we create and use stereotypes, how negative stereotypes about dark skin developed and have played out through history—including being a basis for the transatlantic slave trade. Offering examples of how attitudes about skin color differ in the U.S., Brazil, India, and South Africa, Jablonski suggests that a knowledge of the evolution and social importance of skin color can help eliminate color-based discrimination and racism.

Although a very fragile structure, the skin barrier is probably one of the most important organs of the body. Inward/out it is responsible for body integrity and outward/in for keeping microbes, chemicals, and allergens from penetrating the skin. Since the role of barrier integrity in atopic dermatitis and the relationship to filaggrin mutations was discovered a decade ago, research focus has been on the skin barrier, and numerous new publications have become available. This book is an interdisciplinary update offering a wide range of information on the subject. It covers new basic research on skin markers, including results on filaggrin and on methods for the assessment of the barrier function. Biological variation and aspects of skin barrier function restoration are discussed as well. Further sections are dedicated to clinical implications of skin barrier integrity, factors influencing the penetration of the skin, influence of wet work, and guidance for prevention and saving the barrier. Distinguished researchers have contributed to this book, providing a comprehensive and thorough overview of the skin barrier function. Researchers in the field, dermatologists, occupational physicians, and related industry will find this publication an essential source of information.

The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. From burn victims to surgical scars and plastic surgery, the therapies resulting from skin tissue engineering and regenerative medicine are important to a broad spectrum of patients. Skin Tissue Engineering and Regenerative Medicine provides a translational link for biomedical researchers across fields to understand the inter-disciplinary approaches which expanded available therapies for patients and additional research collaboration. This work expands on the primary literature on the state of the art of cell therapies and biomaterials to review the most widely used surgical therapies for the specific clinical scenarios. - Explores cellular and molecular processes of wound healing, scar formation, and dermal repair - Includes examples of animal models for wound healing and translation to the clinical world - Presents the current state of, and clinical opportunities for, extracellular matrices, natural biomaterials, synthetic biomaterials, biologic skin substitutes, and adult and fetal stem and skin cells for skin regenerative therapies and wound management - Discusses new innovative approaches for wound healing including skin bioprinting and directed cellular therapies

Adolescenceâ€"beginning with the onset of puberty and ending in the mid-20sâ€"is a critical period of development during which key areas of the brain mature and develop. These changes in brain structure, function, and connectivity mark adolescence as a period of opportunity to discover new vistas, to form relationships with peers and adults, and to explore one's developing identity. It is also a period of resilience that can ameliorate childhood setbacks and set the stage for a thriving trajectory over the life course. Because adolescents comprise nearly one-fourth of the entire U.S. population, the nation needs policies and practices that will better leverage these developmental opportunities to harness the promise of adolescenceâ€"rather than focusing myopically on containing its risks. This report examines the neurobiological and socio-behavioral science of adolescent development and outlines how this knowledge can be applied, both to promote adolescent well-being, resilience, and development, and to rectify structural barriers and inequalities in opportunity, enabling all adolescents to flourish.

"Our intimate connection with the world, skin protects us while advertising our health, our identity, and our individuality. This synthetic overview, written with a poetic touch and taking many intriguing side excursions, is a guidebook to the pliable covering that makes us who we are. This book celebrates the evolution of three unique attributes of human skin: its naked sweatiness, its distinctive sepia rainbow of colors, and its remarkable range of decorations. Author Jablonski begins with a look at skin's structure and functions and then tours its three-hundred-million-year evolution, delving into such topics as the importance of touch and how the skin reflects and affects emotions. She examines the modern human obsession with age-related changes in skin, especially wrinkles, then turns to skin as a canvas for self-expression, exploring our use of cosmetics, body paint, tattooing, and scarification"--Publisher's description.

It is the largest and perhaps the most important organ of our body—it covers our fragile inner parts, defines our social identities, and channels our sensory experiences. And yet we rarely give a thought. With The Book of Skin, Steven Connor aims to change all that, offering an intriguing cultural history of skin. Connor first examines physical issues such as leprosy, skin pigmentation, cancer, blushing, and attenuations of erotic touch. He also explains why specific colors symbolize certain emotions, such as green for envy or yellow for cowardice, as well as why skin is the focus of destructive rage in many people’s violent fantasies. The Book of Skin then probes into how skin has been such a powerfully symbolic terrain in photography, religious iconography, cinema, and literature. From the Turin shroud to Ralph Ellison’s Invisible Man to plastic surgery, The Book of Skin expertly examines the role of skin in Western culture. A compelling read that penetrates well beyond skin-deep, The Book of Skin validates James Joyce’s declaration that “modern man has an epidermis rather than a soul.” “Richly conceived and elaborately thought out. No flicker of meaning has escaped Connor’s ferocious, all-seeing eye.”—Guardian