The first annotated edition of the scientific papers that created the foundation of modern neuroscience and physiology The origin of everything known about how neurons and muscles generate electrical signals can be traced back to five revolutionary papers, published in the Journal of Physiology in 1952 by Alan Hodgkin and Andrew Huxley. The principles they revealed remain cornerstones of the discipline, summarized in every introductory neuroscience and physiology course. Since that era, however, scientific practice, technology, and presentation have changed extensively. It is difficult for the modern reader to appreciate Hodgkin and Huxley’s rigorous scientific thought, elegant experimental design, ingenious analysis, and beautiful writing. This book provides the first annotated edition of these papers, offering essential background on everything, from terminology, equations, and electronics, to the greater historical and scientific context surrounding the work. The original journal pages are displayed opposite detailed notes explaining content, process, and background, with copies of the figures replotted according to modern conventions. Indispensable for scientists, teachers, and trainees alike, The Annotated Hodgkin and Huxley makes an essential body of knowledge—and an unparalleled approach to research—accessible to a new generation of readers. Reproduces the original articles paired with extensive annotations on facing pages Replots figures with modern conventions of data display Explains the development of the voltage clamp and the discovery of ionic currents and action potential generation, foundational to the study of neuroscience and physiology Summarizes the history of electrophysiology leading to Hodgkin and Huxley’s work Includes appendices on relevant concepts from mathematics, physics, electronics, chemical kinetics, and numerical methods

with simulations and illustrations by Richard Gray Problem solving is an indispensable part of learning a quantitative science such as neurophysiology. This text for graduate and advanced undergraduate students in neuroscience, physiology, biophysics, and computational neuroscience provides comprehensive, mathematically sophisticated descriptions of modern principles of cellular neurophysiology. It is the only neurophysiology text that gives detailed derivations of equations, worked examples, and homework problem sets (with complete answers). Developed from notes for the course that the authors have taught since 1983, Foundations of Cellular Neurophysiology covers cellular neurophysiology (also some material at the molecular and systems levels) from its physical and mathematical foundations in a way that is far more rigorous than other commonly used texts in this area.

This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.

The starkly different ways that American and French online news companies respond to audience analytics and what this means for the future of news When the news moved online, journalists suddenly learned what their audiences actually liked, through algorithmic technologies that scrutinize web traffic and activity. Has this advent of audience metrics changed journalists’ work practices and professional identities? In Metrics at Work, Angèle Christin documents the ways that journalists grapple with audience data in the form of clicks, and analyzes how new forms of clickbait journalism travel across national borders. Drawing on four years of fieldwork in web newsrooms in the United States and France, including more than one hundred interviews with journalists, Christin reveals many similarities among the media groups examined—their editorial goals, technological tools, and even office furniture. Yet she uncovers crucial and paradoxical differences in how American and French journalists understand audience analytics and how these affect the news produced in each country. American journalists routinely disregard traffic numbers and primarily rely on the opinion of their peers to define journalistic quality. Meanwhile, French journalists fixate on internet traffic and view these numbers as a sign of their resonance in the public sphere. Christin offers cultural and historical explanations for these disparities, arguing that distinct journalistic traditions structure how journalists make sense of digital measurements in the two countries. Contrary to the popular belief that analytics and algorithms are globally homogenizing forces, Metrics at Work shows that computational technologies can have surprisingly divergent ramifications for work and organizations worldwide.

A History of the Brain tells the full story of neuroscience, from antiquity to the present day. It describes how we have come to understand the biological nature of the brain, beginning in prehistoric times, and progressing to the twentieth century with the development of Modern Neuroscience. This is the first time a history of the brain has been written in a narrative way, emphasizing how our understanding of the brain and nervous system has developed over time, with the development of the disciplines of anatomy, pharmacology, physiology, psychology and neurosurgery. The book covers: beliefs about the brain in ancient Egypt, Greece and Rome the Medieval period, Renaissance and Enlightenment the nineteenth century the most important advances in the twentieth century and future directions in neuroscience. The discoveries leading to the development of modern neuroscience gave rise to one of the most exciting and fascinating stories in the whole of science. Written for readers with no prior knowledge of the brain or history, the book will delight students, and will also be of great interest to researchers and lecturers with an interest in understanding how we have arrived at our present knowledge of the brain.

The new edition of Fundamentals of Computational Neuroscience build on the success and strengths of the first edition. Completely redesigned and revised, it introduces the theoretical foundations of neuroscience with a focus on the nature of information processing in the brain.

Mathematical modelling in biomedicine is a rapidly developing scientific discipline at the intersection of medicine, biology, mathematics, physics, and computer science. Its progress is stimulated by fundamental scientific questions and by the applications to public health. This book represents a collection of papers devoted to mathematical modelling of various physiological problems in normal and pathological conditions. It covers a broad range of topics including cardiovascular system and diseases, heart and brain modelling, tumor growth, viral infections, and immune response. Computational models of blood circulation are used to study the influence of heart arrhythmias on coronary blood flow and on operating modes for left-ventricle-assisted devices. Wave propagation in the cardiac tissue is investigated in order to show the influence of tissue heterogeneity and fibrosis. The models of tumor growth are used to determine optimal protocols of antiangiogenic and radiotherapy. The models of viral hepatitis kinetics are considered for the parameter identification, and the evolution of viral quasi-species is investigated. The book presents the state-of-the-art in mathematical modelling in biomedicine and opens new perspectives in this passionate field of research.

A Powerful Approach to Bringing God's Grace to Kids Did you know that the way we deal (or don't deal) with our kids' misbehavior shapes their beliefs about themselves, the world, and God? Therefore it's vital to connect with their hearts--not just their minds--amid the daily behavior battles. With warmth and grace, Jim and Lynne Jackson, founders of Connected Families, offer four tried-and-true keys to handling any behavioral issues with love, truth, and authority. You will learn practical ways to communicate messages of grace and truth, how to discipline in a way that motivates your child, and how to keep your relationship strong, not antagonistic. Discipline is more than just a short-term attempt to modify your child's actions--it's a long-term investment to help them build faith, wisdom, and character for life. When you discover a better path to discipline, you'll find a more well-behaved--and well-believed--kid.

This book presents classical and modern topics in cell physiology, with a focus on the function of nerve, muscle, and secretory cells. The laws of diffusion, electricity, and mass action are explained and applied to elucidate the mechanisms by which cells establish a resting membrane potential, achieve osmotic balance, generate action potentials, initiate secretion, and control muscle contraction. The book is experimentally-grounded but also introduces students to Python, a modern, easy-to-learn programming language with powerful scientific and graphical capabilities. Python programs are used throughout the book to illustrate important physiological principles and results. These programs, the explanatory text, and the exercises at the end of each chapter provide a unique framework for the exploration of cell physiology at a quantitative and mechanistic level.