Investigates how nineteenth-century British literature grappled with a new understanding of aging as both an individual and collective experience. The Aesthetics of Senescence investigates how chronological age has come to possess far-reaching ideological, ethical, and aesthetic implications, both in the past and present. Andrea Charise argues that authors of the nineteenth century used the imaginative resources of literature to engage with an unprecedented climate of crisis associated with growing old. Marshalling a great variety of canonical authors including William Godwin, Mary Shelley, George Eliot, Anthony Trollope, and George Gissing, as well as less familiar writings by George Henry Lewes, Christoph Wilhelm Hufeland, Agnes Strickland, and Max Nordau, Charise demonstrates why the imaginative capacity of writing became an interdisciplinary crucible for testing what it meant to grow old at a time of profound cultural upheaval. Charise’s grounding in medicine, political history, literature, and genre offers a fresh, original, thoroughly interdisciplinary analysis of nineteenth-century aging and age theory, as well as new insights into the rise of the novel—a genre usually thought of as affiliated almost entirely with the young or middle-aged. “Charise’s brilliantly argued, clearly written book is an important intervention in nineteenth-century British literature, age studies, and medical humanities. It brings these areas of inquiry together in what seems a seamless way—as if they have always traveled together or ought to have. Through an investigation of what she calls the ‘aesthetics of embodiment that shaped nineteenth-century visions of aging,’ Charise has given us an original and groundbreaking study of literary, historical, anthropological, and philosophical texts.” — Devoney Looser, author of The Making of Jane Austen

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Excerpt from Senescence and Rejuvenescence The following study of senescence and rejuvenescence is pri marily a register of progress along certain lines of a research program on which I have been engaged during the last fifteen years. This program began with the attempt to analyze experimentally the simpler reproductive processes, but it at once became evident that the whole problem of the organic individual, its origin, development, physiological character, and limiting factors, was involved. In the study of the organic individual the importance of the physio logical age changes soon became apparent and it was found neces sary to devote considerable time to their analysis, for the origin of new individuals by reproduction is in many cases very closely associated with physiological aging. And since the conclusions reached concerning the age cycle finally attained a definite, positive form, differing to some extent from commonly accepted views, but seeming to throw some light upon various other biological problems, it has seemed desirable to attempt a general considera tion and synthesis of the subject of age changes from the point of view which has grown out of the research program mentioned above. It will appear clearly in the following pages that the problems of individuation, reproduction, and age are all closely connected. For that reason it has been necessary to devote a chapter - chap. Ix - to the problem of individuation and reproduction. This chapter is merely a brief statement of some Of the more important evidence and the conclusions reached concerning the nature of the organic individual, a full consideration of the subject being left to another time. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.

Excerpt from Senescence: The Last Half of Life Loughlin, who has not only typed and read the proof of all the book but has been of great assistance in finding references and made many helpful suggestions. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Aging: How Aging Works, How We Reverse Aging, and Prospects for Curing Aging Diseases explains the process of aging beyond mere entropy, exposing it as a complicated and dynamic process that undercuts maintenance and permits age-related disease. With a deeper understanding of the aging process, intervention becomes both easy to understand and clinically feasible. With a solid academic approach, this proposed book builds upon the substantial work published over the past 20 years, citing the newest data, up-to-date models based upon that data, and the implications for improved clinical intervention, including recent developments in gene and cell therapy. Coverage of age-related diseases includes neurodegenerative, cardiovascular, bone and joint, immune system, renal, pulmonary, and skin aging. Future directions of the field focus on interventions, including a summary of previous attempts to intervene in aging and age-related disease, the status of current research, and proposed biotech interventions, as well as their potential obstacles, risks, and benefits. This is the perfect reference for scientists, clinicians, and researchers interested in the translational research opportunities such as drug discovery, pharmacogenetics, and experimental therapeutics, not only summarizing where the field stands, but giving a clear and cogent view of where clinical medicine is going in the next decade. - Provides a sophisticated, accurate, and clear explanation of aging - Gives a clear explanation of the fundamental role of cell aging in age-related disease - Offers a unified model for the role of epigenetic and telomere changes in cell aging - Outlines effective approaches to intervention in the fundamental aging process - Introduces upcoming interventions intended to both cure and prevent age-related diseases

Focusing on the contemporary period, this book brings together critical age studies and contemporary science fiction to establish the centrality of age and ageing in dystopian, speculative and science-fiction imaginaries. Analysing texts from Europe, North America and South Asia, as well as television programmes and films, the contributions range from essays which establish genre-based trends in the representation of age and ageing, to very focused studies of particular texts and concerns. As a whole, the volume probes the relationship between speculative/science fiction and our understanding of what it is to be a human in time: the time of our own lives and the times of both the past and the future.

The Routledge Handbook of Health and Media provides an extensive review and exploration of the myriad ways that health and media function as a symbiotic partnership that profoundly influences contemporary societies. A unique and significant volume in an expanding pedagogical field, this diverse collection of international, original, and interdisciplinary essays goes beyond issues of representation to engage in scholarly conversations about the web of networks that inextricably bind media and health to each other. Divided into sections on film, television, animation, photography, comics, advertising, social media, and print journalism, each chapter begins with a concrete text or texts, using it to raise more general and more theoretical issues about the medium in question. As such, this Handbook defines, expands, and illuminates the role that the humanities and arts play in the education and practice of healthcare professionals and in our understanding of health, illness, and disability. The Routledge Handbook of Health and Media is an invaluable reference for academics, students and health professionals engaged with cultural issues in media and medicine, popular representations of disease and disability, and the patient/professional health care encounter.