This book is a comprehensive and authoritative source on nontuberculous mycobacterial (NTM) pathogens and diseases and their appropriate management, with a focus on lung disease. NTM diseases, especially lung diseases, are increasing in prevalence in the U.S. and internationally with concomitant growing interest in a broad section of the medical community. Often merely included in coverage of tuberculosis, many aspects of NTM organisms and diseases are actually very different than TB. These differences are not intuitive or trivial and frequently result in suboptimal management of NTM patients. This book addresses these gaps in the literature with chapters on microbiology, pathophysiology, epidemiology, the various diseases that can stem from NTM, and their particular management. There is also coverage on prevention and NTM as a public health problem. For pulmonologists and infectious disease physicians, this is the definitive resource on nontuberculous mycobacteria.

1. History 2. Epidemiology of Tuberculosis: Global Perspective 3. Pathology of Tuberculosis 4. The Mycobacteria 5. Immunology of Tuberculosis 6. Genetic Susceptibility Parameters in Tuberculosis 7. Genetics of Susceptibility to Tuberculosis 8. Laboratory Diagnosis of Tuberculosis: Best Practices and Current Policies 9. Roentgenographic Manifestations of Pulmonary and Extra-pulmonary Tuberculosis 10. Pulmonary Tuberculosis 11. Lower Lung Field Tuberculosis 12. Endobronchial Tuberculosis 13. Tuberculosis Pleural Effusion 14. Silicotuberculosis 15. Abdominal Tuberculosis 16. Granulomatous Hepatitis 17. Neurological Tuberculosis 18. Tuberculosis and Heart 19. Skeletal Tuberculosis 20. Musculoskeletal Manifestations of Tuberculosis 21. Cutaneous Tuberculosis 22. Lymph Node Tuberculosis 23. Tuberculosis in Head and Neck 24. Ocular Tuberculosis 25. Tuberculosis in Pregnancy 26. Female Genital Tuberculosis 27. Genitourinary Tuberculosis 28. Tuberculosis in Chronic Kidney Disease 29. Disseminated/Miliary Tuberculosis 30. Tuberculosis at Uncommon Body Sites 31. Complications of Pulmonary Tuberculosis 32. Tuberculosis and Acute Respiratory Distress Syndrome 33. Haematological Manifestations of Tuberculosis 34. Endocrine Implications of Tuberculosis 35. Tuberculosis and Human Immunodeficiency Virus Infection 36. Tuberculosis in Children 37. Surgical Aspects of Childhood Tuberculosis 38. Tuberculosis in the Elderly 39. Tuberculosis in Health Care Workers 40. Nutrition and Tuberculosis 41. Nontuberculous Mycobacterial Infections 42. Drug-resistant Tuberculosis 43. Antituberculosis Drug Resistance Surveillance 44. Treatment of Tuberculosis 45. Hepatotoxicity Associated with Anti-tuberculosis Treatment 46. Surgery for Pleuropulmonary Tuberculosis 47. Stopping TB: The Role of DOTS in Global Tuberculosis Control 48. The Role of Medical Colleges in Tuberculosis Control 49. Public-Private Mix for TB Care 50. Building Partnerships for Tuberculosis Control 51. Integrating Community-based Tuberculosis Activities into the Work of Non-governmental and other Civil Society Organisations [The ENGAGE-TB Approach] 52. WHOÂ's New End TB Strategy 53. The Revised National Tuberculosis Control Programme 54. Tuberculosis Vaccine Development: A Current Perspective 55. Ethical and Legal Issues in Tuberculosis Control 56. Airborne Tuberculosis Transmission and Infection Control Strategies 57. Standards for TB Care in India 58. International Standards for Tuberculosis Care 59. Index-TB Guidelines [Guidelines on Extra-pulmonary Tuberculosis for India] Index

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

Nontuberculous Mycobacteria (NTM): Microbiological, Clinical and Geographical Distribution is a complete reference that stimulates a greater understanding of NTM infections. Sections cover microbiologic and molecular diagnostic tools, drug susceptibility tests, human genetic susceptibility, prevalence and incidence studies, clinical and radiological presentations, and clinical trials for antibiotic therapy. With the incidence rate of NTM infections increasing globally during the last decade, significant mortality and morbidity must be addressed. This important reference will provide research scientists, clinical microbiologists, hospital diagnostic technicians, and post graduate medical and science students with information on the epidemiology, prevalence, microbiology and clinical aspects of NTM.

A comprehensive textbook on tuberculosis that covers all aspects of the disease: epidemiology, microbiology, diagnosis, treatment, control and prevention. The main part of the book comprises very detailed and richly illustrated clinical chapters. The copious images are the advantage of this book. Chapters on new methods and treatments and on animal tuberculosis are included. The material is based on a wealth of experience in tuberculosis as seen in endemic countries such as Saudi Arabia that enjoy free access to advanced investigative and therapeutic facilities. This coexistence of endemicity of the disease and state-of-the-art facilities is rare in poor and developing countries or in rich and developed nations. This multidisciplinary volume is ideal for all clinicians, laboratory and research workers, epidemiologists, university teachers and students, health care planners and international organizations involved in world health and infectious disease.

This well-illustrated book is a comprehensive guide to the cutaneous clinical presentations of mycobacterial infections. The Mycobacterium genus includes over 170 species, nontuberculous mycobacteria (NTM) having been added to the obligate human pathogens such as M. tuberculosis and M. leprae. NTM are widely distributed in the environment with high isolation rates worldwide; the skin is a major target with variable clinical manifestations. A current resurgence in tuberculosis is aggravated by the synergy with human immunodeficiency virus, the breakdown of health care systems, and the rise in multidrug-resistant disease, as the incidence of leprosy remains stable, at around 250,000 new cases annually, regardless of effective antibiotic therapy. Presentations of various cutaneous infections caused by mycobacteria may be overlooked by clinicians owing the lack of familiarity with tuberculosis, leprosy, and the related NTM clinical features. This handy guide will help the dermatologist to spot the different clinical manifestations, make a prompt diagnosis, and apply effective treatment.

This is the second edition of a reference work aimed at all those concerned with dealing with tuberculosis control in developing countries. The book follows in the tradition of Kurt Toman's original work in this field, with the text set out in a question and answer format, grouped under three headings: case detection; treatment, and monitoring. The threat of tuberculosis is still potent, with two million deaths globally. This new edition, containing contributions from a number of experts in this field, addresses the resurgence of tuberculosis, and the emergence of multidrug-resistant bacilli, and the growth of HIV-infected individuals with tuberculosis, as well as recent scientific developments.

Completely updated and revised, Clinical Tuberculosis continues to provide the TB practitioner-whether in public health, laboratory science or clinical practice-with a synoptic and definitive account of the latest methods of diagnosis, treatment and control of this challenging and debilitating disease.New in the Fifth Edition:Gamma interferon-based