Test No 439 In Vitro Skin Irritation Reconstructed Human Epidermis Test Method
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Author |
: OECD |
Publisher |
: OECD Publishing |
Total Pages |
: 18 |
Release |
: 2010-07-23 |
ISBN-10 |
: 9789264090958 |
ISBN-13 |
: 9264090959 |
Rating |
: 4/5 (58 Downloads) |
Synopsis Test No. 439: In Vitro Skin Irritation Reconstructed Human Epidermis Test Method by : OECD
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2 ...
Author |
: Organisation for Economic Co-operation and Development |
Publisher |
: Organisation for Economic Co-operation and Development ; [Montréal : Renouf] |
Total Pages |
: |
Release |
: 1981 |
ISBN-10 |
: 9264122214 |
ISBN-13 |
: 9789264122215 |
Rating |
: 4/5 (14 Downloads) |
Synopsis OECD Guidelines for Testing of Chemicals by : Organisation for Economic Co-operation and Development
Author |
: Hajime Kojima |
Publisher |
: Springer |
Total Pages |
: 136 |
Release |
: 2018-12-27 |
ISBN-10 |
: 9789811324475 |
ISBN-13 |
: 9811324476 |
Rating |
: 4/5 (75 Downloads) |
Synopsis Alternatives to Animal Testing by : Hajime Kojima
This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.
Author |
: Chantra Eskes |
Publisher |
: Springer |
Total Pages |
: 0 |
Release |
: 2018-08-30 |
ISBN-10 |
: 3319843788 |
ISBN-13 |
: 9783319843780 |
Rating |
: 4/5 (88 Downloads) |
Synopsis Alternatives for Dermal Toxicity Testing by : Chantra Eskes
This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol. The closing section addresses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.
Author |
: OECD |
Publisher |
: OECD Publishing |
Total Pages |
: 28 |
Release |
: 2021-06-17 |
ISBN-10 |
: 9789264242845 |
ISBN-13 |
: 9264242848 |
Rating |
: 4/5 (45 Downloads) |
Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method by : OECD
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.
Author |
: OECD |
Publisher |
: OECD Publishing |
Total Pages |
: 21 |
Release |
: 2013-07-26 |
ISBN-10 |
: 9789264203884 |
ISBN-13 |
: 9264203885 |
Rating |
: 4/5 (84 Downloads) |
Synopsis Test No. 439: In Vitro Skin Irritation - Reconstructed Human Epidermis Test Method by : OECD
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2 ...
Author |
: Yvonne Will |
Publisher |
: John Wiley & Sons |
Total Pages |
: 899 |
Release |
: 2016-03-22 |
ISBN-10 |
: 9781119053392 |
ISBN-13 |
: 1119053390 |
Rating |
: 4/5 (92 Downloads) |
Synopsis Drug Discovery Toxicology by : Yvonne Will
As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices
Author |
: Tim Marrs |
Publisher |
: Royal Society of Chemistry |
Total Pages |
: 638 |
Release |
: 2018-02-21 |
ISBN-10 |
: 9781788014045 |
ISBN-13 |
: 1788014049 |
Rating |
: 4/5 (45 Downloads) |
Synopsis Regulatory Toxicology in the European Union by : Tim Marrs
Consumer and environmental protection depend on the careful regulation of all classes of chemicals. Toxicology is the key science used to evaluate safety and so underpins regulatory decisions on chemicals. With the growing body of EU legislation involved in chemical regulation, there is a concomitant need to understand the toxicological principles underlying safety assessments Regulatory Toxicology in the European Union is the first book to cover regulatory toxicology specifically in Europe. It addresses the need for a wider understanding of the principles of regulatory toxicology and their application and presents the relationship between toxicology and legislative processes in regulating chemical commodities across Europe. This title has a broad scope, covering historical and current chemical regulation in Europe, the role of European agencies and institutions, and also the use of toxicology data for important classes of chemicals, including human and veterinary medicines, animal feed and food additives, biocides, pesticides and nanomaterials. This book is therefore extremely pertinent and timely in the toxicology field at present. This book is an essential reference for regulatory authorities, industrialists, academics, undergraduates and postgraduates working within safety and hazards, toxicology, the biological sciences, and the medicinal and pharmaceutical sciences across the European Union.
Author |
: T. Agner |
Publisher |
: Karger Medical and Scientific Publishers |
Total Pages |
: 172 |
Release |
: 2016-02-04 |
ISBN-10 |
: 9783318055863 |
ISBN-13 |
: 3318055867 |
Rating |
: 4/5 (63 Downloads) |
Synopsis Skin Barrier Function by : T. Agner
Although a very fragile structure, the skin barrier is probably one of the most important organs of the body. Inward/out it is responsible for body integrity and outward/in for keeping microbes, chemicals, and allergens from penetrating the skin. Since the role of barrier integrity in atopic dermatitis and the relationship to filaggrin mutations was discovered a decade ago, research focus has been on the skin barrier, and numerous new publications have become available. This book is an interdisciplinary update offering a wide range of information on the subject. It covers new basic research on skin markers, including results on filaggrin and on methods for the assessment of the barrier function. Biological variation and aspects of skin barrier function restoration are discussed as well. Further sections are dedicated to clinical implications of skin barrier integrity, factors influencing the penetration of the skin, influence of wet work, and guidance for prevention and saving the barrier. Distinguished researchers have contributed to this book, providing a comprehensive and thorough overview of the skin barrier function. Researchers in the field, dermatologists, occupational physicians, and related industry will find this publication an essential source of information.
Author |
: OECD |
Publisher |
: OECD Publishing |
Total Pages |
: 25 |
Release |
: 2014-09-26 |
ISBN-10 |
: 9789264224179 |
ISBN-13 |
: 9264224173 |
Rating |
: 4/5 (79 Downloads) |
Synopsis Test No. 489: In Vivo Mammalian Alkaline Comet Assay by : OECD
The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.