Was diabetes evolution's response to the last Ice Age? Did a deadly genetic disease help our ancestors survive the bubonic plagues of Europe? Will a visit to the tanning salon help lower your cholesterol? Why do we age? Why are some people immune to HIV? Can your genes be turned on—or off? Survival of the Sickest is fi lled with fascinating insights and cutting-edge research, presented in a way that is both accessible and utterly absorbing. This is a book about the interconnectedness of all life on earth—and especially what that means for us. Read it. You're already living it.

A Guardian Book of the Week Longlisted for the PEN / E. O. Wilson Literary Science Writing Award An award-winning physician and scientist makes the game-changing case that genetic females are stronger than males at every stage of life Here are some facts: Women live longer than men. They have stronger immune systems. They're better at fighting cancer and surviving famine, and even see the world in a wider variety of colors. They are simply stronger than men at every stage of life. Why is this? And why are we taught the opposite? To find out, Dr. Sharon Moalem drew on his own medical experiences - treating premature babies in the neonatal intensive care unit; recruiting the elderly for neurogenetic studies; tending to HIV-positive orphans in Thailand - and tried to understand why in every instance men were consistently less likely to thrive. The answer, he discovered, lies in our genetics: two X chromosomes offer a powerful survival advantage. With clear, captivating prose that weaves together eye-opening research, case studies, diverse examples ranging from the behavior of honeybees to American pioneers, as well as experiences from his personal life and his own patients, Moalem explains why genetic females triumph over males when it comes to resiliency, intellect, stamina, immunity and much more. He also calls for a reconsideration of our male-centric, one-size-fits-all view of medical studies and even how we prescribe medications - a view that still sees women through the lens of men. Revolutionary and yet utterly convincing, The Better Half will make you see humanity and the survival of our species anew.

This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.

Includes "A-Z of Swedish death metal bands - encyclopedia," with band histories and performers.

A collection of the very first, the very last, and the very best interviews conducted with Prince over his nearly 40 year career. There is perhaps no musician who has had as much influence on the sound of contemporary American music than Prince. His pioneering compositions brought a variety of musical genres into a singular funky and virtuosic sound. In this remarkable collection, and with his signature mix of seduction and demur, the late visionary reflects on his artistry, identity, and the sacrifices and soul-searching it took to stay true to himself. An Introduction by Hanif Abdurraqib offers astute, contemporary perspective and brilliantly contextualizes the collected interviews.

The author of the acclaimed biography of President James Polk, A Country of Vast Designs, offers a fresh, playful, and challenging way of playing “Rating the Presidents,” by pitching historians’ views and subsequent experts’ polls against the judgment and votes of the presidents’ own contemporaries. Merry posits that presidents rise and fall based on performance, as judged by the electorate. Thus, he explores the presidency by comparing the judgments of historians with how the voters saw things. Was the president reelected? If so, did his party hold office in the next election? Where They Stand examines the chief executives Merry calls “Men of Destiny,’’ those who set the country toward new directions. There are six of them, including the three nearly always at the top of all academic polls—Lincoln, Washington, and FDR. He describes the “Split-Decision Presidents’’ (including Wilson and Nixon)—successful in their first terms and reelected; less successful in their second terms and succeeded by the opposition party. He describes the “Near Greats’’ (Jefferson, Jackson, Polk, TR, Truman), the “War Presidents’’ (Madison, McKinley, Lyndon Johnson), the flat-out failures (Buchanan, Pierce), and those whose standing has fluctuated (Grant, Cleveland, Eisenhower). This voyage through our history provides a probing and provocative analysis of how presidential politics works and how the country sets its course. Where They Stand invites readers to pitch their opinions against the voters of old, the historians, the pollsters—and against the author himself. In this year of raucous presidential politics, Where They Stand will provide a context for the unfolding campaign drama.

. Rushkoff introduces us to Cyberia's luminaries, who speak with dazzling lucidity about the rapid-fire change we're all experiencing.

ROBERT MERRY’S BRILLIANT AND HIGHLY ACCLAIMED HISTORY OF A CRUCIAL EPOCH IN U.S. HISTORY. In a one-term presidency, James K. Polk completed the story of America’s Manifest Destiny—extending its territory across the continent by threatening England with war and manufacturing a controversial and unpopular two-year war with Mexico.

In its 114th year, Billboard remains the world's premier weekly music publication and a diverse digital, events, brand, content and data licensing platform. Billboard publishes the most trusted charts and offers unrivaled reporting about the latest music, video, gaming, media, digital and mobile entertainment issues and trends.