Steroid Receptors And Disease
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Author |
: Virinder Moudgil |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 329 |
Release |
: 2013-03-09 |
ISBN-10 |
: 9781468455410 |
ISBN-13 |
: 1468455419 |
Rating |
: 4/5 (10 Downloads) |
Synopsis Steroid Receptors in Health and Disease by : Virinder Moudgil
During the last two decades, progress in steroid hormone research has resulted in the development of new approaches to contraception as well as diagnosis and treatment of endocrine disorders and cancers. Although significant advances have been made in the purification, characterization, immunochemistry and molecular biology of steroid receptors, the precise molecular mechanism of steroid hormone action has remained obscure. This book captures the detailed presentations made at the first conference on Steroid Receptors in Health and Disease held at Meadow Brook Hall, Oakland University in the fall of 1987. The purpose of this international con ference was to facilitate scientific exchange toward a better understand ing of the mode of action of steroid hormones. The scientific sessions consisted of poster presentations and state-of-the-art lectures, the latter of which make up this volume. The first chapter is meant to provide the reader with a more general background of the topics covered in the book, as well as to discuss certain theme-related issues that are either not yet well-established or accepted or are in the stage of infancy. It is hoped that this volume will serve as a useful treatise for students and investigators interested in basic and clinical aspects of biological regulation by steroid hormones. A task of this magnitude could not have been undertaken without the encouragement, advice and continued generous assistance of the members of the scientific committee. I am gratefully indebted to Drs.
Author |
: Peter J. Sheridan |
Publisher |
: |
Total Pages |
: 608 |
Release |
: 1988 |
ISBN-10 |
: UOM:39015014463304 |
ISBN-13 |
: |
Rating |
: 4/5 (04 Downloads) |
Synopsis Steroid Receptors and Disease by : Peter J. Sheridan
Author |
: V. K. Moudgil |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 519 |
Release |
: 2013-03-13 |
ISBN-10 |
: 9781461598497 |
ISBN-13 |
: 1461598494 |
Rating |
: 4/5 (97 Downloads) |
Synopsis Steroid Hormone Receptors: Basic and Clinical Aspects by : V. K. Moudgil
The past few years have witnessed the emergence of steroid hormones as the wonder molecules which generate as much discussion in the scientific literature as they do in a typical living room. This transition has been a result of the tremendous public and scientific interest in the normal functioning of the hor mones as well their suggested involvement in several clinical conditions. In the recent past, notable scientific and technological advances have been made in the areas of contraception and regulation of fertility. Steroid receptors are the indis pensable mediators of hormonal responses and are complex protein molecules which appear to exist in association with other, yet undefined, proteins and/or factors. Receptors for vitamin D, retinoic acid and the thyroid hormones share structural similarities with steroid receptors, and the roster of this superfamily is still expanding. While our knowledge of the diversity and magnitude of steroid effects has advanced, the precise mode of steroid hormone action has alluded investigators. This volume brings together an international team of prominent investigators who discuss their most recent work on the basic and clinical aspects of steroid/nuclear receptors. The contributions represent updated versions of the invited presentations made at The Second Meadow Brook Conference on Steroid Receptors in Health and Disease. I am grateful to my colleagues on the Scientific Committee: Etienne Baulieu, Jack Gorski, Benita Katzenellenbogen, David Toft and James WittJiff, who provided the vision and guidance in formulating an out standing program.
Author |
: Peter J. Sheridan |
Publisher |
: |
Total Pages |
: 600 |
Release |
: |
ISBN-10 |
: 0598038418 |
ISBN-13 |
: 9780598038418 |
Rating |
: 4/5 (18 Downloads) |
Synopsis Steroid Receptors and Disease by : Peter J. Sheridan
Author |
: Raj Kumar |
Publisher |
: Elsevier |
Total Pages |
: 174 |
Release |
: 2023-11-30 |
ISBN-10 |
: 9780323998468 |
ISBN-13 |
: 0323998461 |
Rating |
: 4/5 (68 Downloads) |
Synopsis Steroid Hormone Receptors in Health and Disease by : Raj Kumar
Steroid Hormone Receptors in Endocrine Physiology and Diseases covers the role of steroid hormones in human physiology and receptor activity in the pathophysiology of disease. The book discusses how these receptors can be used as therapeutic targets for the treatment of conditions from cancer to aging, offering immediate applications of biochemical principles into clinical applications such as diagnosis and treatment. This book is a valuable reference for graduate and postdoctoral scientists but is also ideal for medical students interested in the functional role of various steroid hormone receptors in a wide variety of endocrine related diseases.Steroid hormone receptors (SHRs) are known to play vital roles in normal physiology through the control of development, differentiation, metabolic homeostasis and reproduction. Due to their involvement in various pathological and disease conditions, SHRs are also important therapeutic targets in several disorders including inflammation, autoimmune diseases, hormone-dependent cancers, osteoporosis and cardiovascular diseases. - Discusses the importance of steroid hormone receptors in the physiology and pathophysiology of various endocrine related diseases - Provides state-of-the-art information based on key research findings in the field, along with hypotheses and perspectives for future directions for basic and translational research and clinical applications - Offers a comprehensive description of the challenges associated with steroid hormone receptors-based therapies
Author |
: Cheryl S. Watson |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 220 |
Release |
: 2012-12-06 |
ISBN-10 |
: 9781461503392 |
ISBN-13 |
: 1461503396 |
Rating |
: 4/5 (92 Downloads) |
Synopsis The Identities of Membrane Steroid Receptors by : Cheryl S. Watson
Cheryl S. Watson University o/Texas Medical Branch Cellular steroid action has been thoroughly studied in the nuclear compartment. However, nuclear steroid receptor mechanisms have been unable to explain some of the rapid activities of steroids, partiCUlarly those which occur in a time frame of seconds to minutes [reviewed in (1;2)]. Based on these and other considerations, an alternative membrane-associated receptor form was long ago proposed to exist (3). Others interpret the location of the steroid receptors mediating these rapid effects as peri membrane or cytoplasmic. New experimental tools have been brought to bear on the topic of receptors for steroids which mediate non-genomic actions, and thus investigative activity and focus regarding this type of steroid receptor has recently increased significantly. However, there may be multiple answers to the question "how do steroids mediate rapid nongenomic effects?" Steroid actions initiated at the cell membrane can impinge on important phases in the lifespan of a cell: proliferation, migration, differentiation, and release of hormones or neurotransmitters functioning as signals to other cells.
Author |
: Arun K. Roy |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 247 |
Release |
: 2012-12-06 |
ISBN-10 |
: 9781461236665 |
ISBN-13 |
: 1461236665 |
Rating |
: 4/5 (65 Downloads) |
Synopsis Gene Regulation by Steroid Hormones IV by : Arun K. Roy
The first Meadowbrook Symposium was held in 1978 and during the intervening ten years our knowledge concerning how steroid hormones function at the level of gene expression has advanced by leaps and bounds. In this volume, which sum marizes our fourth meeting, these advances are very evident. What seemed like science fiction ten years ago has become commonplace science. Who would have imagined that we could synthesize a nucleotide sequence that binds a specific steroid receptor and acts as a controlling element for gene expression? No one; but as is evident from the results reported in several chapters, this technique is yielding a wealth of information. Using these and other techniques it has become apparent that gene transcription is controlled by interactions between transacting factors and DNA recognition sequences (response elements). These transacting factors appear to be members of a large gene family that includes steroid hormone receptors, transcription factors, protooncogenes and homeobox proteins. Thus a great deal has been learned, but as usual, questions remain. Many of these questions are posed by the findings and observations found in several chapters in this volume. Non hormone binding forms of steroid receptors and their relevance to receptor down regulation, recycling and biological response remain a mystery. The quantitative relationship between receptor binding and biological response still presents agonizing problems. These and many other intriguing questions are discussed in this volume and set the stage for what should be a most rewarding time in endocrinology. Winter 1989 ARUN K.
Author |
: V. K. Moudgil |
Publisher |
: |
Total Pages |
: |
Release |
: 1994 |
ISBN-10 |
: 3764336943 |
ISBN-13 |
: 9783764336943 |
Rating |
: 4/5 (43 Downloads) |
Synopsis Steroid Hormone Receptors by : V. K. Moudgil
Author |
: Thomas C. Spelsberg |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 418 |
Release |
: 2012-12-06 |
ISBN-10 |
: 9781461320739 |
ISBN-13 |
: 1461320739 |
Rating |
: 4/5 (39 Downloads) |
Synopsis Steroid and Sterol Hormone Action by : Thomas C. Spelsberg
The purpose of this book is to focus attention on recent developments in steroid and sterol hormone action. Many authors have generously contributed to the book. As a result, there is a great diversity of opinion! A majority of the chapters deal with steroid or sterol hormone receptors. This is not meant to imply that receptor-mediated mechanisms are the sole or even the most important mechanisms by which steroid hormones act in the cell. There is wealth of evidence showing that other, non-receptor events, are important also. Steroid hormone recep tor research and the study of nuclear events mediated by steroids are presently the most intensely studied aspects of sterol hormone action and our selection of topics reflects this trend. We have also included chapters on vitamin 0 sterols and thyroid hormone in the book, as there is pood evidence that these hormones act in a manner similar to other classical steroids. 1 IMMUNOCHARACTERIZATION OF THE NUCLEAR ACCEPTOR SITES FOR THE AVIAN OVIDUCT PROGESTERONE RECEPTOR A. GOLDBERGER, M. HORTON, T. C. SPELSBERG Department of Biochemistry and Molecular Biology, Mayo Clinic and Mayo Graduate School of Medicine, Rochester, MN 55905 INTRODUCTION It is well known that steroid hormones, certain vitamins and sterols, enter target cells and bind to specific protein receptors in the cyto plasm or nucleus (1-4). This binding is saturable, high affinity, and steroid specific.
Author |
: Pertschuk |
Publisher |
: CRC Press |
Total Pages |
: 182 |
Release |
: 2018-02-01 |
ISBN-10 |
: 9781351082600 |
ISBN-13 |
: 1351082604 |
Rating |
: 4/5 (00 Downloads) |
Synopsis Localization Of Putative Steroid Receptors by : Pertschuk
These volumes represent the "state-of-the-art" in morphological methods for detection of steroid receptors. Some physician authors have applied many of the new methodologies in clinical research projects deisgned to improve medical practice, and these attempts have been placed in Volume II. The Background and recent advances presented here are intended to stimulate further experimentation and new innovations, and spur clinical trials by all investigators with an interest in steroid hormones, cell biology, and clinical oncology.