Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

This is the story of steroid-protein interactions as one investigator sees it. Following the general concept of this monograph series, it emphasizes the results and interpretations obtained in the author's laboratory, and is therefore a subjective account. Recognizing, how ever, that the discussion of the subject would be incomplete if the material were limited to one scientist's work, the essential achieve ments of other investigators have been incorporated. An effort has thus been made to give a balanced presentation and to enable the reader to see in perspective the varied facets of the interactions between steroids and proteins. Since this is the first comprehensive treatment of the topic, it seems appropriate to go to the roots, and try to find out how it all started. The first chapters, therefore, take the reader to the laboratories of those who very early conceived the significance of the attachment of dyes, drugs, and other conspicuous molecules to those colloids called proteins. The discovery of the steroid hormones set the stage for meaningful investigation of their interaction with proteins of various origins and functions - a process which is continuing today with increasing vigor.

This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders.KEY FEATURES* Includes updated information on early diagnosis of ovarian cancer* Reviews new diagnostic techniques for ovarian disorders* Discusses latest information on reproductive technology* Presents translational treatment linking laboratory research with clinical medicine

Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations

This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.

Volume One of Hormones and the Fetus contained a generalization of the role of hormones during fetal life. In this second volume, the main topics focus on hormonal binding to fetal and maternal plasma proteins, amniotic fluid and placenta; the presence of hormone receptors in the fetal compartment; and the mechanism of action of various hormones in different target tissues of the fetus and placenta. This up-to-date information is of major importance in the study of hormonal activity in fetal life, and the biological effect of hormones through the receptor. The mechanism of fetal sexual differentiation, in which hormones play an important role, is extensively covered.

Comprised of nearly 400 entries by leading experts on the subject, "The Encyclopedia of Stress" covers almost every aspect and ramification of stress. The book explores the effects of stress on behavior, psychiatric and psychosomatic disorders, cardiovascular systems, reproductive function, and immune function, plus stress as a consequence of work, post-traumatic stress, and stress and predisposition to disease. (Social Sciences--Psychology)

Stress is generally defined as a strain upon a bodily organ or mental power. Depending on its duration and intensity, stress can have short- or long-lasting effects: it has been linked to heart disease, immune deficiency, memory loss, behavioral disorders, and much more. These effects on the individual also have a major impact on health care costs and services, employee productivity, and even violent crime. The Encyclopedia of Stress is the first comprehensive reference source on stressors, the biological mechanisms involved in the stress response, the effects of activating the stress response mechanisms, and the disorders that may arise as a consequence of acute or chronic stress. While other books focus on specific aspects of stress, this three-volume set covers the entire spectrum of topics, with nearly 400 articles in all. In addition to the subjects traditionally associated with the hypothalamic-pituitary-adrenal axis (whereby the brain sends a message to the body to react), the Encyclopedia includes a wide range of related topics such as neuroimmune interactions, cytokines, enzymatic disorders, effects on the cardiovascular system, immunity and inflammation, and physical illnesses. It also goes beyond the biological aspects of stress to cover topics such as stress and behavior, psychiatric and psychosomatic disorders, workplace stress, post-traumatic stress, stress-reduction techniques, and current therapies. The Encyclopedia of Stress makes information easy to find and understand for a broad audience of researchers, clinicians, professionals, and students. Key Features * Presenting the first-ever encyclopedia on stress * Brings together the latest information on stressors, stress responses, and the disorders that can result * Covers stress from molecules to man to societies * Contains nearly 400 articles, covering a wide range of stress-related topics * Arranges topics in easily found alphabetical order * Supplements each article with a glossary and further reading list * Provides the most comprehensive coverage of stress available * Includes extensive cross-referencing between articles and a complete subject index * Covers hot topics, ranging from stress in the workplace and post-traumatic stress disorder to stress-related diseases * Edited by one of the world's leading authorities on stress * Written by more than 560 experts from 20 different countries * Appeals to a wide audience seeking information on topics within and outside their areas of expertise