Steroid Hormone Resistance
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Author |
: George P. Chrousos |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 436 |
Release |
: 2012-12-06 |
ISBN-10 |
: 9781468451016 |
ISBN-13 |
: 1468451014 |
Rating |
: 4/5 (16 Downloads) |
Synopsis Steroid Hormone Resistance by : George P. Chrousos
This volume represents the first attempt to present in one place the clinical syndromes and the pathophysiologic basis for the "resistance states" to each of the classes of steroid hormones. Glucocorticoids, mineralocorticoids, androgens, estrogens, progesterone and vitamin D have widely diverse roles ranging from the control of homeostasis to reproduction and bone formation. They are similar in that they share a chemical structure and that their action is in the cell nucleus where they induce transcription of specific genes leading to synthesis of function-specific proteins. Clinical syndromes of steroid hormone resistance to androgens (complete and partial testicular feminization), aldosterone (pseudo hypoaldosteronism) and vitamin D (vitamin D-dependent rickets type II) have been known for many years. Progesterone and glucocorticoid resistance syndromes have been described only recently. Resistance to estrogens has not been reported in man or in animals. It is hoped that a detailed reexamination of what is known about each of these conditions at the clinical and molecular levels will enhance our understanding of the function of these hormones and their mechanisms of action. New insight and research initiatives should result. G.P. Chrousos D.L. Loriaus M.B. Lipsett vii ACKNOWLEDGMENTS The contents of this volume are based in part on the proceedings of an International Conference held in Bethesda in the summer of 1984. This conference was sponsored by the National Institute of Child Health and Human Development, Bethesda, Maryland.
Author |
: Deutsche Forschungsgemeinschaft (DFG). Sonderforschungsbereich 351 |
Publisher |
: |
Total Pages |
: |
Release |
: 1996 |
ISBN-10 |
: OCLC:83847062 |
ISBN-13 |
: |
Rating |
: 4/5 (62 Downloads) |
Synopsis Novel Aspects of Steroid Hormone Resistance by : Deutsche Forschungsgemeinschaft (DFG). Sonderforschungsbereich 351
Author |
: Richard E. Brown |
Publisher |
: Cambridge University Press |
Total Pages |
: 434 |
Release |
: 1994-01-27 |
ISBN-10 |
: 0521426650 |
ISBN-13 |
: 9780521426657 |
Rating |
: 4/5 (50 Downloads) |
Synopsis An Introduction to Neuroendocrinology by : Richard E. Brown
This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.
Author |
: Malcolm G. Parker |
Publisher |
: IRL Press |
Total Pages |
: 242 |
Release |
: 1993 |
ISBN-10 |
: UOM:39015032752316 |
ISBN-13 |
: |
Rating |
: 4/5 (16 Downloads) |
Synopsis Steroid Hormone Action by : Malcolm G. Parker
This volume provides a detailed overview of the mechanisms by which steroid hormones regulate gene activity in target cells. It should be of interest to molecular biologists, endocrinologists, pharmacologists and clinicians interested in gene regulation hormones and steroid antagonists.
Author |
: Robert C. Bast, Jr. |
Publisher |
: John Wiley & Sons |
Total Pages |
: 2004 |
Release |
: 2017-03-10 |
ISBN-10 |
: 9781119000846 |
ISBN-13 |
: 111900084X |
Rating |
: 4/5 (46 Downloads) |
Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author |
: J. Carlstedt-Duke |
Publisher |
: Birkhäuser |
Total Pages |
: 360 |
Release |
: 2013-11-21 |
ISBN-10 |
: 9783034854665 |
ISBN-13 |
: 3034854668 |
Rating |
: 4/5 (65 Downloads) |
Synopsis The Steroid/Thyroid Hormone Receptor Family and Gene Regulation by : J. Carlstedt-Duke
The Second International CBT (Center for Biotechnology) Synposium was held in Stockholm November 4-5 1988 and had the title "The steroid/thyroid hoITIDne receptor family and gene regulation". This meeting contained contributions from most leading laboratories within the field of steroid/thyroid hOITIDne receptors and gave a very exciting perspective on the dynamic development of this i:ntx>rt. ant research field. Today all known steroid hoITIDne receptors have been cloned and sequenced and novel members of this supergene family are constantly being discovered. Sane of these new receptors remain to be characterized regarding the nature of their ligand. Access to probes for steroid receptors has enabled studies on mechanisms of regulation of receptor gene expression. Deletion and II'Altational analysis of steroid receptor cDNAs followed by expression in cells together with suitable reporter genes has yielded a detailed knowledge about the functional significance of the various domains the receptors are composed of. In certain cases, steroid resistance in patients have been shown to be due to point mutations in the corresponding steroid receptor genes resulting in non-functional receptors. The availability of receptor cDNAs also makes it possible to express receptors at high levels in procaryotic and eucaryotic cells. It is e. g. possible to express the DNA-binding domain of the glucocorticoid receptor in E. coli as a fusion protein with protein A which interacts specifically with DNA. Such studies are necessary for production of sufficient quantities of receptors to allow crystallization and X-ray crystallography for detailed structural information.
Author |
: Margo P. Cohen |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 260 |
Release |
: 2012-12-06 |
ISBN-10 |
: 9781461247586 |
ISBN-13 |
: 1461247586 |
Rating |
: 4/5 (86 Downloads) |
Synopsis Hormone Resistance and Other Endocrine Paradoxes by : Margo P. Cohen
Endocrinology and Metabolism: Progress in Research and Clinical Prac tice is a new series that has been designed to present timely, critical reviews of constantly evolving fields; to provide practical and up-to-date guidance in the solution of pertinent clinical problems; to offer an alterna tive to the laborious search of the literature (and the often frustrating reading of highly technical articles); and to translate the language of the laboratory into that of the practice of medicine. We think that this volume and those to come will prove useful to physi cians (and to physicians in training), as well as to investigators in a wide variety of specialties; in short, to anyone who seeks answers to questions in endocrinology and metabolism. The first chapter of this volume could well serve as a general introduc tion to the entire series. It points out how our growing understanding of the molecular basis of biologic communication has led to the discovery of a growing number of clinical syndromes, as well as to the realization that phenotypically similar diseases may have radically different pathogenetic mechanisms and thus may require radically different therapeutic strata gems.
Author |
: Karen Michelle Wood |
Publisher |
: |
Total Pages |
: 104 |
Release |
: 1983 |
ISBN-10 |
: OCLC:13387910 |
ISBN-13 |
: |
Rating |
: 4/5 (10 Downloads) |
Synopsis Steroid Hormone Resistance by : Karen Michelle Wood
Author |
: Gabriella Castoria |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 271 |
Release |
: 2011-12-15 |
ISBN-10 |
: 9781461417644 |
ISBN-13 |
: 1461417643 |
Rating |
: 4/5 (44 Downloads) |
Synopsis Advances in Rapid Sex-Steroid Action by : Gabriella Castoria
Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers.
Author |
: Nicholas Bruchovsky |
Publisher |
: CRC Press |
Total Pages |
: 242 |
Release |
: 2019-06-04 |
ISBN-10 |
: 9780429557408 |
ISBN-13 |
: 042955740X |
Rating |
: 4/5 (08 Downloads) |
Synopsis Drug and Hormone Resistance in Neoplasia by : Nicholas Bruchovsky
Published in 1983: In Volume 2 the clinical aspects of drug and hormone resistance are discussed. The Editors have concentrated on malignancies of the breast, endometrium, and prostate as relevant clinical examples.