Setting out the principles of stereology from a statistical viewpoint, this book focuses on both basic theory and practical implications. The authors discuss ways to effectively communicate statistical issues to clients, draw attention to common methodological errors, and provide references to essential literature. The first full text on design-based stereology opens with a review of classical and modern stereology, followed by a treatment of mathematical foundations and then on to core techniques. The final chapters discuss implementing techniques in practical sampling designs, summarize understanding of the variance of stereological estimators, and describe open problems for further research. The book also details isotropic, vertical or local sampling designs for estimating stereological parameters such as volume, surface area, particle number and spatial distribution. This extensive text offers support to statistical consultants using examples, applications and unique Advice to Consultants sections. It contains numerous literature references, bibliographic notes and nearly 150 illustrations.

vi on geometric probability is included, students can be expected to create a few simple programs like those shown, but for other geometries. I am indebted to Tom Hare for critical reviews of the material and an endless enthusiasm to debate and derive stereological relationships; to John Matzka at Plenum Press for patiently instructing me in the intricacies of typesetting; to Chris Russ for helping to program many of these measurement techniques; and especially to Helen Adams, both for her patience with my creative fever to write yet another book, and for pointing out that the title, which I had intended to contrast to "theoretical stereology," can also be understood as the antonym of "impractical stereology." John C. Russ Raleigh,NC July, 1986 Chapter 1: Statistics 1 Accuracy and precision 1 The mean and standard deviation 5 Distributions 7 Comparison 13 Correlation 18 Nonlinear fitting 19 Chapter 2: Image Types 23 Planar sections 23 Projected images 25 Finite sections 28 Space-filling structures and dispersed phases 29 Types of images and contrast mechanisms 31 Sampling 32 Chapter 3: Manual Methods 35 Volume fraction 35 Surface density 38 Contiguity 41 Mean intercept length 42 Line density 43 Grain size determination 55 Curvature 48 Reticles to aid counting 49 Magnification and units 51 Chapter4: Size Distributions 53 Intercept length in spheres 53 Nonspherical shapes 57 Corrections for finite section thickness 59 Lamellae 61 Measurement of profile size 62 Nonspherical particles 69 vii Contents viii Chapter 5: Computer Metlwds 73

Unbiased Stereology, Second Edition is a practical guide to making unbiased 3-D measurements via the microscope. Only those stereological techniques which have been tried and tested by real application are included. Although this technology is essentially mathematical and statistical, the authors do not immerse the reader in complex analysis, but rather provide simple heuristic explanations and references to the original proof, and illustrate the theory by analogies drawn from everyday experience. To give practical experience in application of the techniques, exercises are provided at the end of each chapter, complete with detailed worked answers.

Setting out the principles of stereology from a statistical viewpoint, this book focuses on both basic theory and practical implications. The authors discuss ways to effectively communicate statistical issues to clients, draw attention to common methodological errors, and provide references to essential literature. The first full text on design-bas

The Wiley-Interscience Paperback Series consists of selected booksthat have been made more accessible to consumers in an effort toincrease global appeal and general circulation. With these newunabridged softcover volumes, Wiley hopes to extend the lives ofthese works by making them available to future generations ofstatisticians, mathematicians, and scientists. "Books such as this that bring together, clarify, and summarizerecent research can lead to a great increase of interest in thearea. . . . a major achievement in describing many aspects ofspatial data and discussing, with examples, different methods ofanalysis." –Royal Statistical Society "Dr. Ripley’s book is an excellent survey of the spatialstatistical methodology. It is very well illustrated with examples[that] give a clear view of the wide scope of the subject, the wayin which techniques often have to be tailored to particularapplications, and the different sorts of spatial data thatarise." –The Bulletin of the London Mathematics Society Spatial Statistics provides a comprehensive guide to theanalysis of spatial data. Each chapter covers a particular dataformat and the associated class of problems, introducing theory,giving computational suggestions, and providing examples. Methodsare illustrated by computer-drawn figures. The book serves as anintroduction to this rapidly growing research area formathematicians and statisticians, and as a reference to newcomputer methods for researchers in ecology, geology, archaeology,and the earth sciences.

Stereological techniques allow biologists to create quantitative, three-dimensional descriptions of biological structures from two- dimensional images of tissue viewed under the microscope. For example, they can accurately estimate the size of a particular organelle, the total length of a mass of capillaries, or the number of neurons or synapses in a particular region of the brain. This book provides a practical guide to designing and critically evaluating stereological studies of the nervous system and other tissues. It explains the basic concepts behind design-based stereology and how to get started. Also included are detailed descriptions of how to prepare tissue appropriately, perform pilot studies and decide on the appropriate sampling strategy, and account for phenomena such as tissue shrinkage. Numerous examples of applications of stereological methods that are applicable to studies of the central system and a wide variety of other tissues are explained. The book is therefore essential reading for neurobiologists and cell biologists interested in generating accurate representations of cell and tissue architecture.

The investigation of the origin and formation of microstructures and the effect that microstructure has on the properties of materials are important issues in materials science and technology. Geometrical analysis is often the key to understanding the formation of microstructures and the resulting material properties. The authors make use of mathematical morphology, spatial statistics, image processing, stereology and stochastic geometry to analyze microstructures arising in materials science. * Quantitative microstructure analysis is one of the most successful experimental techniques in materials science * Uses examples to demonstrate the techniques * Program code included enables the reader to apply the numerous algorithms * Accessible to material scientists with limited statistical knowledge Primarily aimed at applied materials scientists, the book will also appeal to those working and researching in earth sciences, material technology, mineralogy, petrography, image analysis, cytology and biology.

Point processes and random measures find wide applicability in telecommunications, earthquakes, image analysis, spatial point patterns, and stereology, to name but a few areas. The authors have made a major reshaping of their work in their first edition of 1988 and now present their Introduction to the Theory of Point Processes in two volumes with sub-titles Elementary Theory and Models and General Theory and Structure. Volume One contains the introductory chapters from the first edition, together with an informal treatment of some of the later material intended to make it more accessible to readers primarily interested in models and applications. The main new material in this volume relates to marked point processes and to processes evolving in time, where the conditional intensity methodology provides a basis for model building, inference, and prediction. There are abundant examples whose purpose is both didactic and to illustrate further applications of the ideas and models that are the main substance of the text.

Explore the classic and cutting-edge quantitative methods for understanding environmental science research Based on the multifaceted 16-volume Encyclopedia of Statistical Sciences, Second Edition, Methods and Applications of Statistics in the Atmospheric and Earth Sciences offers guidance on the application of statistical methods for conducting research in these fields of study. With contributions from more than 100 leading experts in academia and industry, this volume combines key articles from the Encyclopedia with newly developed topics addressing some of the more critical issues, including pollution, droughts, and volcanic activity. Readers will gain a thorough understanding of cutting-edge methods for the acquisition and analysis of data across a wide range of subject areas, from geophysics, geology, and biogeography to meteorology, forestry, agriculture, animal science, and ornithology. The book features new and updated content on quantitative methods and their use in understanding the latest topics in social research, including: Drought Analysis and Forecasting Childhood Obesity Ranked Set Sampling Methodology for Environmental Data Species Richness and Shared Species Richness Geographic Information Systems Each contribution offers authoritative yet easily accessible coverage of statistical concepts. With updated references and discussion of emerging topics, readers are provided with the various statistical methods, techniques, strategies, and applications that are essential for tackling critical issues in environmental science research. Featuring a balance of classical and cutting-edge methodologies, Methods and Applications of Statistics in the Atmospheric and Earth Sciences is an excellent resource for researchers, professionals, and students in the fields of sociology, psychology, philosophy, education, political science, and the related disciplines who would like to learn about the uses of statistics in gathering, reporting, and analyzing data.

Point process statistics is successfully used in fields such as material science, human epidemiology, social sciences, animal epidemiology, biology, and seismology. Its further application depends greatly on good software and instructive case studies that show the way to successful work. This book satisfies this need by a presentation of the spatstat package and many statistical examples. Researchers, spatial statisticians and scientists from biology, geosciences, materials sciences and other fields will use this book as a helpful guide to the application of point process statistics. No other book presents so many well-founded point process case studies. From the reviews: "For those interested in analyzing their spatial data, the wide variatey of examples and approaches here give a good idea of the possibilities and suggest reasonable paths to explore." Michael Sherman for the Journal of the American Statistical Association, December 2006